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Breast Carcinoma In Situ

Breast Carcinoma In Situ Abstract • A total of 150 patients with in situ breast cancer were treated from 1970 through 1976, with a median follow-up of 11.5 years. There were 42 patients with microinvasion and 25 with bilateral disease, analyzed separately. Eight patients who became unavailable for follow-up within five years (but who had no evidence of disease [NED]) were excluded. Eighty-five patients had ductal carcinoma in situ, 43 had lobular carcinoma in situ, and 22 had a mixed type. Modified radical mastectomy was done in 112 cases. One of 128 patients had positive axillary nodes; axillary dissection is not indicated for in situ breast cancer. Of the 150 patients, one with ductal disease died of disease. Six died of other causes, free of disease. Of 18 treated by excision alone, two underwent mastectomy for recurrence and had NED. Patients with microinvasion had involved nodes in 10%, and 94% had NED. However, all bilateral cases had NED. (Arch Surg 1989;124:33-36) References 1. Ashikari R, Hajdu SI, Robbins GF: Intraductal carcinoma of the breast (1960-1969) . Cancer 1971;28:1182-1187.Crossref 2. Brown PW, Silverman J, Owens E, et al: Intraductal 'noninfiltrating' carcinoma of the breast . Arch Surg 1976;111:1063-1067.Crossref 3. Von Reuden DG, Wilson RE: Intraductal carcinoma of the breast . Surg Gynecol Obstet 1984;158:105-111. 4. Rosen PP, Braun DW Jr, Kinne DW: The clinical significance of preinvasive breast carcinoma . Cancer 1980;46:919-925.Crossref 5. Wanebo HJ, Huvos AG, Urben JA: Treatment of minimal breast cancer . Cancer 1974;33:349-357.Crossref 6. Ashikari R, Huvos AG, Snyder RE: Prospective study of non-infiltrating carcinoma of the breast . Cancer 1977;39:435-439.Crossref 7. Carter D, Smith RRL: Carcinoma in situ of the breast . Cancer 1977; 40:1189-1193.Crossref 8. Rosner D, Bedwani RN, Vana J, et al: Noninvasive breast carcinoma: Results of a national survey by the American College of Surgeons . Ann Surg 1980;192:139-147.Crossref 9. Haagensen CD: Disease of the Breast , ed 2. Philadelphia, WB Saunders Co, 1971, p 586. 10. Rosen PP, Senie R, Schottenfeld D, et al: Noninvasive breast carcinoma: Frequency of unsuspected invasion and implications for treatment . Ann Surg 1979;189:377-382.Crossref 11. Gump FE: In situ cancers , in Harris JR, Hellman S, Henderson IC, et al (eds): Breast Disease . Philadelphia, JB Lippincott, 1987, pp 359-368. 12. Gump FE, Jicha DL, Ozello L: Ductal carcinoma in situ (DCIS): A revised concept . Surgery 1987;102:790-795. 13. Frykberg ER, Santiago F, Betsill WL Jr, et al: Lobular carcinoma in situ of the breast . Surg Gynecol Obstet 1987;164:285-301. 14. Betsill WL, Rosen PP, Lieberman PH, et al: Intraductal carcinoma: Long-term follow-up after treatment by biopsy alone . JAMA 1978;239:1863-1867.Crossref 15. Page DL, Dupont WD, Rogers LW, et al: Intraductal carcinoma of the breast: Follow-up after biopsy only . Cancer 1982;49:751-758.Crossref 16. Rosen PP, Lieberman PH, Braun DW Jr, et al: Lobular carcinoma in situ of the breast: Detailed analysis of 99 patients with an average follow-up of 24 years . Am J Surg Pathol 1978;2:225-251.Crossref 17. Farrow JH: Current concepts in the detection and treatment of the earliest of the early breast cancers . Cancer 1970;25:468-477.Crossref 18. Sunshine JA, Moseley HS, Fletcher WS, et al: Breast carcinoma in situ: A retrospective review of 112 cases with a minimum ten year follow-up . Am J Surg 1985;150:44-51.Crossref 19. Silverstein MJ, Rosser RJ, Gierson ED, et al: Axillary lymph node dissection for intraductal breast carcinoma: Is it indicated? Cancer 1987;59:1819-1824.Crossref 20. Fisher ER, Sass R, Fisher B, et al: Pathologic findings from the National Surgical Adjuvant Breast Project (Protocol 6): I. Intraductal carcinoma (DCIS) . Cancer 1986;57:197-208.Crossref 21. Schnitt SJ, Silen W, Sadowsky NL, et al: Ductal carcinoma in situ (intraductal carcinoma) of the breast . N Engl J Med 1988;318:898-903.Crossref 22. Schuh ME, Nemoto T, Penetrante RB, et al: Intraductal carcinoma: Analysis of presentation, pathologic findings, and outcome of disease . Arch Surg 1986;121:1303-1307.Crossref 23. Schwartz GF, Feig SA, Rosenberg AL, et al: Staging and treatment of clinically occult breast cancer . Cancer 1984;53:1379-1384.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1989.01410010039008
Publisher site
See Article on Publisher Site

Abstract

Abstract • A total of 150 patients with in situ breast cancer were treated from 1970 through 1976, with a median follow-up of 11.5 years. There were 42 patients with microinvasion and 25 with bilateral disease, analyzed separately. Eight patients who became unavailable for follow-up within five years (but who had no evidence of disease [NED]) were excluded. Eighty-five patients had ductal carcinoma in situ, 43 had lobular carcinoma in situ, and 22 had a mixed type. Modified radical mastectomy was done in 112 cases. One of 128 patients had positive axillary nodes; axillary dissection is not indicated for in situ breast cancer. Of the 150 patients, one with ductal disease died of disease. Six died of other causes, free of disease. Of 18 treated by excision alone, two underwent mastectomy for recurrence and had NED. Patients with microinvasion had involved nodes in 10%, and 94% had NED. However, all bilateral cases had NED. (Arch Surg 1989;124:33-36) References 1. Ashikari R, Hajdu SI, Robbins GF: Intraductal carcinoma of the breast (1960-1969) . Cancer 1971;28:1182-1187.Crossref 2. Brown PW, Silverman J, Owens E, et al: Intraductal 'noninfiltrating' carcinoma of the breast . Arch Surg 1976;111:1063-1067.Crossref 3. Von Reuden DG, Wilson RE: Intraductal carcinoma of the breast . Surg Gynecol Obstet 1984;158:105-111. 4. Rosen PP, Braun DW Jr, Kinne DW: The clinical significance of preinvasive breast carcinoma . Cancer 1980;46:919-925.Crossref 5. Wanebo HJ, Huvos AG, Urben JA: Treatment of minimal breast cancer . Cancer 1974;33:349-357.Crossref 6. Ashikari R, Huvos AG, Snyder RE: Prospective study of non-infiltrating carcinoma of the breast . Cancer 1977;39:435-439.Crossref 7. Carter D, Smith RRL: Carcinoma in situ of the breast . Cancer 1977; 40:1189-1193.Crossref 8. Rosner D, Bedwani RN, Vana J, et al: Noninvasive breast carcinoma: Results of a national survey by the American College of Surgeons . Ann Surg 1980;192:139-147.Crossref 9. Haagensen CD: Disease of the Breast , ed 2. Philadelphia, WB Saunders Co, 1971, p 586. 10. Rosen PP, Senie R, Schottenfeld D, et al: Noninvasive breast carcinoma: Frequency of unsuspected invasion and implications for treatment . Ann Surg 1979;189:377-382.Crossref 11. Gump FE: In situ cancers , in Harris JR, Hellman S, Henderson IC, et al (eds): Breast Disease . Philadelphia, JB Lippincott, 1987, pp 359-368. 12. Gump FE, Jicha DL, Ozello L: Ductal carcinoma in situ (DCIS): A revised concept . Surgery 1987;102:790-795. 13. Frykberg ER, Santiago F, Betsill WL Jr, et al: Lobular carcinoma in situ of the breast . Surg Gynecol Obstet 1987;164:285-301. 14. Betsill WL, Rosen PP, Lieberman PH, et al: Intraductal carcinoma: Long-term follow-up after treatment by biopsy alone . JAMA 1978;239:1863-1867.Crossref 15. Page DL, Dupont WD, Rogers LW, et al: Intraductal carcinoma of the breast: Follow-up after biopsy only . Cancer 1982;49:751-758.Crossref 16. Rosen PP, Lieberman PH, Braun DW Jr, et al: Lobular carcinoma in situ of the breast: Detailed analysis of 99 patients with an average follow-up of 24 years . Am J Surg Pathol 1978;2:225-251.Crossref 17. Farrow JH: Current concepts in the detection and treatment of the earliest of the early breast cancers . Cancer 1970;25:468-477.Crossref 18. Sunshine JA, Moseley HS, Fletcher WS, et al: Breast carcinoma in situ: A retrospective review of 112 cases with a minimum ten year follow-up . Am J Surg 1985;150:44-51.Crossref 19. Silverstein MJ, Rosser RJ, Gierson ED, et al: Axillary lymph node dissection for intraductal breast carcinoma: Is it indicated? Cancer 1987;59:1819-1824.Crossref 20. Fisher ER, Sass R, Fisher B, et al: Pathologic findings from the National Surgical Adjuvant Breast Project (Protocol 6): I. Intraductal carcinoma (DCIS) . Cancer 1986;57:197-208.Crossref 21. Schnitt SJ, Silen W, Sadowsky NL, et al: Ductal carcinoma in situ (intraductal carcinoma) of the breast . N Engl J Med 1988;318:898-903.Crossref 22. Schuh ME, Nemoto T, Penetrante RB, et al: Intraductal carcinoma: Analysis of presentation, pathologic findings, and outcome of disease . Arch Surg 1986;121:1303-1307.Crossref 23. Schwartz GF, Feig SA, Rosenberg AL, et al: Staging and treatment of clinically occult breast cancer . Cancer 1984;53:1379-1384.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Jan 1, 1989

References

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