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Brainstem Serotonergic Deficiency in Sudden Infant Death Syndrome

Brainstem Serotonergic Deficiency in Sudden Infant Death Syndrome PRELIMINARY COMMUNICATION Brainstem Serotonergic Deficiency in Sudden Infant Death Syndrome Jhodie R. Duncan, PhD Context Sudden infant death syndrome (SIDS) is postulated to result from abnor- malities in brainstem control of autonomic function and breathing during a critical de- David S. Paterson, PhD velopmental period. Abnormalities of serotonin (5-hydroxytryptamine [5-HT]) recep- Jill M. Hoffman, BS tor binding in regions of the medulla oblongata involved in this control have been reported David J. Mokler, PhD in infants dying from SIDS. Natalia S. Borenstein, MS Objective To test the hypothesis that 5-HT receptor abnormalities in infants dying from SIDS are associated with decreased tissue levels of 5-HT, its key biosynthetic en- Richard A. Belliveau, BA zyme (tryptophan hydroxylase [TPH2]), or both. Henry F. Krous, MD Design, Setting, and Participants Autopsy study conducted to analyze levels of Elisabeth A. Haas, BA 5-HT and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA); levels of TPH2; and 5-HT receptor binding. The data set was accrued between 2004 and 2008 and con- Christina Stanley, MD 1A sisted of 41 infants dying from SIDS (cases), 7 infants with acute death from known Eugene E. Nattie, MD causes (controls), and 5 hospitalized infants with chronic hypoxia-ischemia. Felicia L. Trachtenberg, PhD http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2010.45
pmid
20124538
Publisher site
See Article on Publisher Site

Abstract

PRELIMINARY COMMUNICATION Brainstem Serotonergic Deficiency in Sudden Infant Death Syndrome Jhodie R. Duncan, PhD Context Sudden infant death syndrome (SIDS) is postulated to result from abnor- malities in brainstem control of autonomic function and breathing during a critical de- David S. Paterson, PhD velopmental period. Abnormalities of serotonin (5-hydroxytryptamine [5-HT]) recep- Jill M. Hoffman, BS tor binding in regions of the medulla oblongata involved in this control have been reported David J. Mokler, PhD in infants dying from SIDS. Natalia S. Borenstein, MS Objective To test the hypothesis that 5-HT receptor abnormalities in infants dying from SIDS are associated with decreased tissue levels of 5-HT, its key biosynthetic en- Richard A. Belliveau, BA zyme (tryptophan hydroxylase [TPH2]), or both. Henry F. Krous, MD Design, Setting, and Participants Autopsy study conducted to analyze levels of Elisabeth A. Haas, BA 5-HT and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA); levels of TPH2; and 5-HT receptor binding. The data set was accrued between 2004 and 2008 and con- Christina Stanley, MD 1A sisted of 41 infants dying from SIDS (cases), 7 infants with acute death from known Eugene E. Nattie, MD causes (controls), and 5 hospitalized infants with chronic hypoxia-ischemia. Felicia L. Trachtenberg, PhD

Journal

JAMAAmerican Medical Association

Published: Feb 3, 2010

References