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Brain Swelling Caused by Trauma and Arterial Hypertension: Hemodynamic Aspects

Brain Swelling Caused by Trauma and Arterial Hypertension: Hemodynamic Aspects Abstract THE EXPERIMENTS to be reported here are part of a study of the effect of brain injury on cerebral vasomotor tone and the contribution of alterations in cerebral vasomotor reactivity to brain swelling. Closed head injury in experimental animals has been shown to impair the vasoconstrictor properties of the resistance vessels in the brain. Cerebral blood flow increases immediately following the injury1-3 as much as 250% with the postconcussive rise in blood pressure.3 Experimental head injury also causes brain swelling, manifested by marked intracranial hypertension, and cerebral blood volume may increase several fold.4,5 Interpretation of the results in some experiments has been made difficult by intracranial hemorrhage caused by the injury.4 Recently, however, Lewis et al5 reported that closed head injury in cats produces a marked increase in cerebral blood volume without hemorrhage. These observations suggest that the vasomotor properties of cerebral vessels are References 1. German, W.J., et al: Cerebral Blood Flow and Cerebral Oxygen Consumption in Experimental Intracranial Injury , Trans Amer Neurol Assoc 72:86-88, 1947. 2. Meyer, J.S., and Denny-Brown, D.: Studies of Cerebral Circulation in Brain Injury: II. Cerebral Concussion , Electroenceph Clin Neurophysiol 7:529-544 ( (Nov) ) 1955.Crossref 3. Brown, G.W., and Brown, M.L.: Cardiovascular Responses to Experimental Cerebral Concussion in the Rhesus Monkey , Arch Neurol Psychiat 71:707-713 ( (June) ) 1954.Crossref 4. Langfitt, T.W., et al: Contribution of Intracranial Blood Volume to Three Forms of Experimental Brain Swelling , John Hopkins Med J 122:261-270 ( (May) ) 1968. 5. Lewis, H.P., et al: Intracranial Blocd Volume After Head Injury , Surg Forum 19:433-435, 1968. 6. Schutta, H.S., et al: Brain Swelling Produced By Injury and Aggravated by Arterial Hypertension: A Light and Electron Microscopic Study , Brain 91( (pt 2) ):281-294, 1968.Crossref 7. Shulman, K.: Small Artery and Vein Pressures in the Subarachnoid Space of the Dog , J Surg Res 5:56-61 ( (Feb) ) 1965.Crossref 8. Klatzo, I., et al: The Application of Fluorescein Labeled Serum Proteins (F.L.S.P.) to the Study of Vascular Permeability in the Brain , Acta Neuropathol 2:144-160, 1962.Crossref 9. Bakay, L., and Haque, I.U.: Morphological and Chemical Studies in Cerebral Edema , J Neuropath Exp Neurol 23:393-418 ( (July) ) 1964.Crossref 10. Klatzo, I.: Neuropathological Aspects of Brain Edema, Presidential Address , J Neuropath Exp Neurol 26:1-14 ( (Jan) ) 1967.Crossref 11. Prados, M., et al: Studies on Cerebral Edema: Reaction on the Brain to Air Exposures; Pathologic Change , Arch Neurol Psychiat 54:163-174 ( (Sept) ) 1945.Crossref 12. Brock, M.: Regional Cerebral Blood Flow Changes Following Local Brain Compression in the Cat, "CBF and CSF" Third International Symposium , Scand J Clin Lab Invest , (suppl) 102, 1968. 13. Hoedt-Rasmussen, K., et al: Regional Cerebral Blood Flow in Acute Apoplexy , Arch Neurol 17:271-281 ( (Sept) ) 1967.Crossref 14. Johnson, P.C.: Review of Previous Studies and Current Theories of Autoregulation , Circ Res 15:2-9 ( (Aug) ) 1964. 15. Langfitt, T.W., et al: Compression of Cerebral Vessels by Intracranial Hypertension: I. Dural Sinus Pressures , Acta Neurochir 15( (pt 3-4) ):212-221, 1966.Crossref 16. Shapiro, H.M., et al: Compression of Cerebral Vessels by Intracranial Hypertension: II. Morphological Evidence for Collapse of Vessels , Acta Neurochir 15( (pt 3-4) ):223-233, 1966.Crossref 17. White, J.C.: Changes in Brain Volume During Anaesthesia: The Effects cf Anoxia and Hypercapnia , Arch Surg 44:1-21 ( (Jan) ) 1942.Crossref 18. Zweifach, B.W.: Permeability Aspects of Blood Tissue Exchange , Invest Ophthal 4:1065-1074 ( (Dec) ) 1965. 19. Harper, A.M.: The Inter-Relationship Between aPco2 and Blood Pressure in the Regulation of Blood Flow Through the Cerebral Cortex , Acta Neurol Scand 94 ( (suppl 14) ), 1965. 20. Haggendal, E., and Johansson, B.: Effects of Arterial Carbon Dioxide Tension and Oxygen Saturation on Cerebral Blood Flow Autoregulation in Dogs , Acta Physiol Scand 27( (suppl 258) ), 1965. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Brain Swelling Caused by Trauma and Arterial Hypertension: Hemodynamic Aspects

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1969.00480170117012
Publisher site
See Article on Publisher Site

Abstract

Abstract THE EXPERIMENTS to be reported here are part of a study of the effect of brain injury on cerebral vasomotor tone and the contribution of alterations in cerebral vasomotor reactivity to brain swelling. Closed head injury in experimental animals has been shown to impair the vasoconstrictor properties of the resistance vessels in the brain. Cerebral blood flow increases immediately following the injury1-3 as much as 250% with the postconcussive rise in blood pressure.3 Experimental head injury also causes brain swelling, manifested by marked intracranial hypertension, and cerebral blood volume may increase several fold.4,5 Interpretation of the results in some experiments has been made difficult by intracranial hemorrhage caused by the injury.4 Recently, however, Lewis et al5 reported that closed head injury in cats produces a marked increase in cerebral blood volume without hemorrhage. These observations suggest that the vasomotor properties of cerebral vessels are References 1. German, W.J., et al: Cerebral Blood Flow and Cerebral Oxygen Consumption in Experimental Intracranial Injury , Trans Amer Neurol Assoc 72:86-88, 1947. 2. Meyer, J.S., and Denny-Brown, D.: Studies of Cerebral Circulation in Brain Injury: II. Cerebral Concussion , Electroenceph Clin Neurophysiol 7:529-544 ( (Nov) ) 1955.Crossref 3. Brown, G.W., and Brown, M.L.: Cardiovascular Responses to Experimental Cerebral Concussion in the Rhesus Monkey , Arch Neurol Psychiat 71:707-713 ( (June) ) 1954.Crossref 4. Langfitt, T.W., et al: Contribution of Intracranial Blood Volume to Three Forms of Experimental Brain Swelling , John Hopkins Med J 122:261-270 ( (May) ) 1968. 5. Lewis, H.P., et al: Intracranial Blocd Volume After Head Injury , Surg Forum 19:433-435, 1968. 6. Schutta, H.S., et al: Brain Swelling Produced By Injury and Aggravated by Arterial Hypertension: A Light and Electron Microscopic Study , Brain 91( (pt 2) ):281-294, 1968.Crossref 7. Shulman, K.: Small Artery and Vein Pressures in the Subarachnoid Space of the Dog , J Surg Res 5:56-61 ( (Feb) ) 1965.Crossref 8. Klatzo, I., et al: The Application of Fluorescein Labeled Serum Proteins (F.L.S.P.) to the Study of Vascular Permeability in the Brain , Acta Neuropathol 2:144-160, 1962.Crossref 9. Bakay, L., and Haque, I.U.: Morphological and Chemical Studies in Cerebral Edema , J Neuropath Exp Neurol 23:393-418 ( (July) ) 1964.Crossref 10. Klatzo, I.: Neuropathological Aspects of Brain Edema, Presidential Address , J Neuropath Exp Neurol 26:1-14 ( (Jan) ) 1967.Crossref 11. Prados, M., et al: Studies on Cerebral Edema: Reaction on the Brain to Air Exposures; Pathologic Change , Arch Neurol Psychiat 54:163-174 ( (Sept) ) 1945.Crossref 12. Brock, M.: Regional Cerebral Blood Flow Changes Following Local Brain Compression in the Cat, "CBF and CSF" Third International Symposium , Scand J Clin Lab Invest , (suppl) 102, 1968. 13. Hoedt-Rasmussen, K., et al: Regional Cerebral Blood Flow in Acute Apoplexy , Arch Neurol 17:271-281 ( (Sept) ) 1967.Crossref 14. Johnson, P.C.: Review of Previous Studies and Current Theories of Autoregulation , Circ Res 15:2-9 ( (Aug) ) 1964. 15. Langfitt, T.W., et al: Compression of Cerebral Vessels by Intracranial Hypertension: I. Dural Sinus Pressures , Acta Neurochir 15( (pt 3-4) ):212-221, 1966.Crossref 16. Shapiro, H.M., et al: Compression of Cerebral Vessels by Intracranial Hypertension: II. Morphological Evidence for Collapse of Vessels , Acta Neurochir 15( (pt 3-4) ):223-233, 1966.Crossref 17. White, J.C.: Changes in Brain Volume During Anaesthesia: The Effects cf Anoxia and Hypercapnia , Arch Surg 44:1-21 ( (Jan) ) 1942.Crossref 18. Zweifach, B.W.: Permeability Aspects of Blood Tissue Exchange , Invest Ophthal 4:1065-1074 ( (Dec) ) 1965. 19. Harper, A.M.: The Inter-Relationship Between aPco2 and Blood Pressure in the Regulation of Blood Flow Through the Cerebral Cortex , Acta Neurol Scand 94 ( (suppl 14) ), 1965. 20. Haggendal, E., and Johansson, B.: Effects of Arterial Carbon Dioxide Tension and Oxygen Saturation on Cerebral Blood Flow Autoregulation in Dogs , Acta Physiol Scand 27( (suppl 258) ), 1965.

Journal

Archives of NeurologyAmerican Medical Association

Published: Nov 1, 1969

References

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