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Brain Protein May Play a Role in Depression-Related Behaviors

Brain Protein May Play a Role in Depression-Related Behaviors News & Analysis Lab Reports Protein May Play Dual Role Creutzfeldt-Jakobdisease,whichaffectscog- in Diabetes Pathogenesis nition, represented the 2 diseases analyzed Aproteinknowntodriveprogrammeddeath in the study. Other examples of prion dis- of pancreatic beta cells in both type 1 and eases include Gerstmann-Sträussler- type 2 diabetes also causes these cells to Scheinker syndrome in humans, bovine stop making insulin, report researchers from spongiform encephalopathy in cattle, and theUniversityofAlabamaatBirmingham(Xu scrapie in sheep and goats. Lateral habenula Getal. Nat Med. doi:10.1038/nm.3287 [pub- The findings suggest that exchanging a Medial habenula lished online August 25, 2013]). single amino acid can cause different neu- Experiments using microarrays as well as rodegenerative diseases and trigger the for- cells from mice and humans revealed that mation of different transmissible prions. The the protein, called thioredoxin-interacting results may help explain how mutations in protein (TXNIP), triggers beta cells to make different regions of the prion protein in hu- a short piece of genetic material called mans contribute to infectious neurodegen- microRNA-204 that interferes with expres- erative diseases that each begin with patho- sion of MAFA, a transcription factor known logic processes in different brain regions and Mice with higher levels of βCaMKII protein (green) to turn on the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Brain Protein May Play a Role in Depression-Related Behaviors

JAMA , Volume 310 (13) – Oct 2, 2013

Brain Protein May Play a Role in Depression-Related Behaviors

Abstract

News & Analysis Lab Reports Protein May Play Dual Role Creutzfeldt-Jakobdisease,whichaffectscog- in Diabetes Pathogenesis nition, represented the 2 diseases analyzed Aproteinknowntodriveprogrammeddeath in the study. Other examples of prion dis- of pancreatic beta cells in both type 1 and eases include Gerstmann-Sträussler- type 2 diabetes also causes these cells to Scheinker syndrome in humans, bovine stop making insulin, report researchers from spongiform encephalopathy in cattle,...
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Publisher
American Medical Association
Copyright
Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2013.278394
Publisher site
See Article on Publisher Site

Abstract

News & Analysis Lab Reports Protein May Play Dual Role Creutzfeldt-Jakobdisease,whichaffectscog- in Diabetes Pathogenesis nition, represented the 2 diseases analyzed Aproteinknowntodriveprogrammeddeath in the study. Other examples of prion dis- of pancreatic beta cells in both type 1 and eases include Gerstmann-Sträussler- type 2 diabetes also causes these cells to Scheinker syndrome in humans, bovine stop making insulin, report researchers from spongiform encephalopathy in cattle, and theUniversityofAlabamaatBirmingham(Xu scrapie in sheep and goats. Lateral habenula Getal. Nat Med. doi:10.1038/nm.3287 [pub- The findings suggest that exchanging a Medial habenula lished online August 25, 2013]). single amino acid can cause different neu- Experiments using microarrays as well as rodegenerative diseases and trigger the for- cells from mice and humans revealed that mation of different transmissible prions. The the protein, called thioredoxin-interacting results may help explain how mutations in protein (TXNIP), triggers beta cells to make different regions of the prion protein in hu- a short piece of genetic material called mans contribute to infectious neurodegen- microRNA-204 that interferes with expres- erative diseases that each begin with patho- sion of MAFA, a transcription factor known logic processes in different brain regions and Mice with higher levels of βCaMKII protein (green) to turn on the

Journal

JAMAAmerican Medical Association

Published: Oct 2, 2013

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