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Brain Monoamines and Amino Acids in Gilles de la Tourette's Syndrome: A Preliminary Study of Subcortical Regions

Brain Monoamines and Amino Acids in Gilles de la Tourette's Syndrome: A Preliminary Study of... Abstract To the Editor. — We have measured levels of monoamines, monoamine metabolites, amino acids, and neurotransmitter-related enzymes in subcortical regions of postmortem tissue obtained from brains of four individuals who had Gilles de la Tourette's syndrome (TS). Although the study was limited by the small number of available brains and other concomitants of postmortem analyses, several suggestive differences were seen between the brains of subjects with TS and those of the control group. Most intriguing in terms of possible pathophysiologic significance were the observation of generally lower values of serotonin and its related compounds in the TS group, and the lower TS group means of glutamate in the three major projection areas of the subthalamic nucleus (STN): the medial globus pallidus (MGP), lateral globus pallidus (LGP), and substantia nigra reticulata (SNR). Subjects and Methods.— The brains of four subjects who were diagnosed before death as having TS were obtained. One References 1. Stevens TJ, Bird ED. Microdissections of nuclear areas from human brain slices . In: Cuello AC, ed. IBRO Handbook Series: Methods in the Neurosciences: Brain Microdissection Techniques . New York, NY: John Wiley & Sons Inc; 1983;2:171-183. 2. Singer HS, Hahn 1-H, Moran TH. Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's syndrome . Ann Neurol . 1991;30:558-562.Crossref 3. Shapiro AK, Shapiro ES, Young JG, Feinberg TN, eds. Gilles de la Tourette Syndrome . 2nd ed. New York, NY: Raven Press; 1988. 4. Comings DE. Blood serotonin and tryptophan in Tourette syndrome . Am J Med Genet . 1990;36:418-430.Crossref 5. Crossman AR. Neural mechanisms in disorders of movement . Comp Biochem Physiol A . 1989;3:141-149.Crossref 6. DeLong MR. Primate models of movement disorders of basal ganglia origin . Trends Neurosci . 1990;13:281-285.Crossref 7. Alexander GE, Crutcher MD. Functional architecture of basal ganglia circuits: neural substrates of parallel processing . Trends Neurosci . 1990;13:266-271.Crossref 8. Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders . Trends Neurosci . 1989;12:366-375.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Brain Monoamines and Amino Acids in Gilles de la Tourette's Syndrome: A Preliminary Study of Subcortical Regions

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Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1992.01820070078016
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. — We have measured levels of monoamines, monoamine metabolites, amino acids, and neurotransmitter-related enzymes in subcortical regions of postmortem tissue obtained from brains of four individuals who had Gilles de la Tourette's syndrome (TS). Although the study was limited by the small number of available brains and other concomitants of postmortem analyses, several suggestive differences were seen between the brains of subjects with TS and those of the control group. Most intriguing in terms of possible pathophysiologic significance were the observation of generally lower values of serotonin and its related compounds in the TS group, and the lower TS group means of glutamate in the three major projection areas of the subthalamic nucleus (STN): the medial globus pallidus (MGP), lateral globus pallidus (LGP), and substantia nigra reticulata (SNR). Subjects and Methods.— The brains of four subjects who were diagnosed before death as having TS were obtained. One References 1. Stevens TJ, Bird ED. Microdissections of nuclear areas from human brain slices . In: Cuello AC, ed. IBRO Handbook Series: Methods in the Neurosciences: Brain Microdissection Techniques . New York, NY: John Wiley & Sons Inc; 1983;2:171-183. 2. Singer HS, Hahn 1-H, Moran TH. Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's syndrome . Ann Neurol . 1991;30:558-562.Crossref 3. Shapiro AK, Shapiro ES, Young JG, Feinberg TN, eds. Gilles de la Tourette Syndrome . 2nd ed. New York, NY: Raven Press; 1988. 4. Comings DE. Blood serotonin and tryptophan in Tourette syndrome . Am J Med Genet . 1990;36:418-430.Crossref 5. Crossman AR. Neural mechanisms in disorders of movement . Comp Biochem Physiol A . 1989;3:141-149.Crossref 6. DeLong MR. Primate models of movement disorders of basal ganglia origin . Trends Neurosci . 1990;13:281-285.Crossref 7. Alexander GE, Crutcher MD. Functional architecture of basal ganglia circuits: neural substrates of parallel processing . Trends Neurosci . 1990;13:266-271.Crossref 8. Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders . Trends Neurosci . 1989;12:366-375.Crossref

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Jul 1, 1992

References