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Botulinum Toxin A for Treatment of Sialorrhea in Children

Botulinum Toxin A for Treatment of Sialorrhea in Children ORIGINAL ARTICLE ONLINE FIRST Botulinum Toxin A for Treatment of Sialorrhea in Children An Effective, Minimally Invasive Approach Waqas Ullah Khan, BSc; Paolo Campisi, MSc, MD, FRCSC; Sanjeevan Nadarajah, MD; Yaseer Abdul Shakur, BSc, MSc; Nasir Khan, BSc, MD; Dan Semenuk, BSc, DDS; Cathy McCann, MSc; Lisa Roske, MA; Sharon McConney-Ellis, MA; Melissa Joseph, MSW; Dimitri Parra, MD; Joao Amaral, MD; Philip John, MB, FRCPC; Michael Temple, MD; Bairbre Connolly, MB, FRCPC Objectives: To report (1) our experience with botuli- and caregiver overall assessment of the child’s posttreat- num toxin A injections into the salivary glands of pedi- ment quality of life. atric patients with sialorrhea, (2) the clinical outcomes of these interventions, and (3) the associated complica- Results: Forty-five subjects received a total of 91 botu- tion rates. linum toxin A treatments. The mean (SD) duration of effect was 4.6 (5.2) months. Duration of effect (log trans- Design: Retrospective cohort study. formed) was significantly negatively associated with sa- liva quantity (P=.02), and there was a positive associa- Setting: Urban pediatric hospital and pediatric reha- tion with both increasing age and female sex, although bilitation center. neither reached statistical significance (P=.08 for each). Seven of the 24 documented complications http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Otolaryngology - Head & Neck Surgery American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6181
eISSN
2168-619X
DOI
10.1001/archoto.2010.240
pmid
21242533
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE ONLINE FIRST Botulinum Toxin A for Treatment of Sialorrhea in Children An Effective, Minimally Invasive Approach Waqas Ullah Khan, BSc; Paolo Campisi, MSc, MD, FRCSC; Sanjeevan Nadarajah, MD; Yaseer Abdul Shakur, BSc, MSc; Nasir Khan, BSc, MD; Dan Semenuk, BSc, DDS; Cathy McCann, MSc; Lisa Roske, MA; Sharon McConney-Ellis, MA; Melissa Joseph, MSW; Dimitri Parra, MD; Joao Amaral, MD; Philip John, MB, FRCPC; Michael Temple, MD; Bairbre Connolly, MB, FRCPC Objectives: To report (1) our experience with botuli- and caregiver overall assessment of the child’s posttreat- num toxin A injections into the salivary glands of pedi- ment quality of life. atric patients with sialorrhea, (2) the clinical outcomes of these interventions, and (3) the associated complica- Results: Forty-five subjects received a total of 91 botu- tion rates. linum toxin A treatments. The mean (SD) duration of effect was 4.6 (5.2) months. Duration of effect (log trans- Design: Retrospective cohort study. formed) was significantly negatively associated with sa- liva quantity (P=.02), and there was a positive associa- Setting: Urban pediatric hospital and pediatric reha- tion with both increasing age and female sex, although bilitation center. neither reached statistical significance (P=.08 for each). Seven of the 24 documented complications

Journal

JAMA Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Apr 1, 2011

References

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