ORIGINAL ARTICLE ONLINE FIRST Botulinum Toxin A for Treatment of Sialorrhea in Children An Effective, Minimally Invasive Approach Waqas Ullah Khan, BSc; Paolo Campisi, MSc, MD, FRCSC; Sanjeevan Nadarajah, MD; Yaseer Abdul Shakur, BSc, MSc; Nasir Khan, BSc, MD; Dan Semenuk, BSc, DDS; Cathy McCann, MSc; Lisa Roske, MA; Sharon McConney-Ellis, MA; Melissa Joseph, MSW; Dimitri Parra, MD; Joao Amaral, MD; Philip John, MB, FRCPC; Michael Temple, MD; Bairbre Connolly, MB, FRCPC Objectives: To report (1) our experience with botuli- and caregiver overall assessment of the child’s posttreat- num toxin A injections into the salivary glands of pedi- ment quality of life. atric patients with sialorrhea, (2) the clinical outcomes of these interventions, and (3) the associated complica- Results: Forty-five subjects received a total of 91 botu- tion rates. linum toxin A treatments. The mean (SD) duration of effect was 4.6 (5.2) months. Duration of effect (log trans- Design: Retrospective cohort study. formed) was significantly negatively associated with sa- liva quantity (P=.02), and there was a positive associa- Setting: Urban pediatric hospital and pediatric reha- tion with both increasing age and female sex, although bilitation center. neither reached statistical significance (P=.08 for each). Seven of the 24 documented complications
JAMA Otolaryngology - Head & Neck Surgery – American Medical Association
Published: Apr 1, 2011
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera