Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Botulinum A Toxin Injection as a Treatment for Blepharospasm

Botulinum A Toxin Injection as a Treatment for Blepharospasm Abstract • Thirty-nine patients with blepharospasm were treated with injections of botulinum A toxin into the lid and brow. The maximum number of injections in one patient was 16 over a period of 24 months. A reduction of abnormal movement occurred in all patients, lasting up to 170 days. Both the amount and the duration of effect were dose dependent. Reinjection for recurrence had effects similar to the original injection. Tearing, dry-eye symptoms, or transient ptosis occurred in 20% of injections, especially in patients who had had previous eyelid surgery. References 1. Jankovic J, Havins WE, Wilkins RB: Blinking and blepharospasm: Mechanism, diagnosis, and management . JAMA 1982; 248:3160-3164.Crossref 2. McCord CD, Coles WH, Shore JW, et al: Treatment of essential blepharospasm: I. Comparison of facial nerve avulsion and eyebrow-eyelid muscle stripping procedure . Arch Ophthalmol 1984;102:266-268.Crossref 3. Frueh BR, Callahan A, Dortzbach R, et al: The effect of differential section of the seventh nerve on patients with intractable blepharospasm . Trans Am Acad Ophthalmol Otolaryngol 1976;81:596-602. 4. Weingarten CZ, Putterman AM: Management of patients with essential blepharospasm . Ear Nose Throat J 1976;55:183-188. 5. Scott AB: Botulinum toxin injection of eye muscle to correct strabismus . Trams Am Ophthalmol Soc 1981;79:734-770. 6. Davies JR, Morgan RS, Wright EA, et al: The result of direct injection of botulinum toxin into the CNS of rabbits . J Physiol 1953;120:618-623. 7. Frueh BR, Felt DP, Wojno TH, et al: Treatment of blepharospasm with botulinum toxin: A preliminary report . Arch Ophthalmol 1984;102:1464-1468.Crossref 8. Gillum WN, Anderson RL: Blepharospasm surgery: An anatomical approach . Arch Ophthalmol 1981;99:1056-1062.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Botulinum A Toxin Injection as a Treatment for Blepharospasm

Loading next page...
 
/lp/american-medical-association/botulinum-a-toxin-injection-as-a-treatment-for-blepharospasm-lC2C0UG41t
Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1985.01050030043017
Publisher site
See Article on Publisher Site

Abstract

Abstract • Thirty-nine patients with blepharospasm were treated with injections of botulinum A toxin into the lid and brow. The maximum number of injections in one patient was 16 over a period of 24 months. A reduction of abnormal movement occurred in all patients, lasting up to 170 days. Both the amount and the duration of effect were dose dependent. Reinjection for recurrence had effects similar to the original injection. Tearing, dry-eye symptoms, or transient ptosis occurred in 20% of injections, especially in patients who had had previous eyelid surgery. References 1. Jankovic J, Havins WE, Wilkins RB: Blinking and blepharospasm: Mechanism, diagnosis, and management . JAMA 1982; 248:3160-3164.Crossref 2. McCord CD, Coles WH, Shore JW, et al: Treatment of essential blepharospasm: I. Comparison of facial nerve avulsion and eyebrow-eyelid muscle stripping procedure . Arch Ophthalmol 1984;102:266-268.Crossref 3. Frueh BR, Callahan A, Dortzbach R, et al: The effect of differential section of the seventh nerve on patients with intractable blepharospasm . Trans Am Acad Ophthalmol Otolaryngol 1976;81:596-602. 4. Weingarten CZ, Putterman AM: Management of patients with essential blepharospasm . Ear Nose Throat J 1976;55:183-188. 5. Scott AB: Botulinum toxin injection of eye muscle to correct strabismus . Trams Am Ophthalmol Soc 1981;79:734-770. 6. Davies JR, Morgan RS, Wright EA, et al: The result of direct injection of botulinum toxin into the CNS of rabbits . J Physiol 1953;120:618-623. 7. Frueh BR, Felt DP, Wojno TH, et al: Treatment of blepharospasm with botulinum toxin: A preliminary report . Arch Ophthalmol 1984;102:1464-1468.Crossref 8. Gillum WN, Anderson RL: Blepharospasm surgery: An anatomical approach . Arch Ophthalmol 1981;99:1056-1062.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1985

References