Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Blue-on-Yellow Perimetry Can Predict the Development of Glaucomatous Visual Field Loss

Blue-on-Yellow Perimetry Can Predict the Development of Glaucomatous Visual Field Loss Abstract • Objective. —The purpose of this investigation was to determine whether blue-on-yellow (B/Y) perimetry is capable of predicting the onset and location of impending glaucomatous visual field loss in patients with ocular hypertension. Design. —A Humphrey Field Analyzer (Humphrey Instruments, San Leandro, Calif) was modified to perform B/Y perimetry to isolate and measure the sensitivity of short-wavelength—sensitive mechanisms. Participants were tested annually with standard white-on-white (W/W) and B/Y automated perimetry for a period of 5 years. Patients. —The study population consisted of 38 patients with ocular hypertension and 62 age-matched normal control subjects. Results. —Initially, all 76 ocular hypertensive eyes had normal W/W automated perimetry results, with 67 eyes having normal and nine eyes having abnormal B/Y test results. Five years later, five of the nine ocular hypertensive eyes with initial B/Y abnormal results developed glaucomatous visual field loss measured by standard W/W automated perimetry, while none of the 67 ocular hypertensive eyes with initially normal B/Y results developed abnormal W/W perimetry results. Conclusions. —Blue-on-yellow perimetry deficits are an early indicator of glaucomatous damage and are predictive of impending glaucomatous visual field loss for standard W/W automated perimetry. To our knowledge, this is the first prospective, long-term longitudinal study that demonstrates the ability to predict the onset of glaucomatous visual field loss in patients with ocular hypertension on the basis of psychophysical testing. References 1. Adams AJ, Heron G, Husted R. Clinical measures of central visual function in glaucoma and ocular hypertension . Arch Ophthalmol . 1987;105:782.Crossref 2. Adams AJ, Rodic R, Husted R, Stamper R. Spectral sensitivity and color discrimination changes in glaucoma and glaucoma-suspects . Invest Ophthalmol Vis Sci . 1982;23:516-524. 3. Sample PA, Weinreb RN, Boynton RM. Acquired dyschromatopsia in glaucoma . Surv Ophthalmol . 1986;31:54-64.Crossref 4. Drance SM, Lakowski R, Schulzer M, Douglas GR. Acquired color vision changes in glaucoma: use of 100-Hue Test and Pickford anomaloscope as predictors of glaucomatous field change . Arch Ophthalmol . 1981;99:829-831.Crossref 5. Heron G, Adams AJ, Husted R. Central visual fields for short wavelength sensitive pathways in glaucoma and ocular hypertension . Invest Ophthalmol Vis Sci . 1988;29:64-72. 6. Sample PA, Boynton R, Weinreb R. Isolating the color vision loss in primary open angle glaucoma . Am J Ophthalmol . 1988;106:686-691. 7. Sample PA, Weinreb RN. Color perimetry for assessment of primary open-angle glaucoma . Invest Ophthalmol Vis Sci . 1990;31:1869-1875. 8. Johnson CA, Adams AJ, Twelker JD, Quigg JM. Age related changes of the central visual field for short wavelength sensitive (SWS) pathways . J Opt Soc Am . 1988;5:2131-2139.Crossref 9. Johnson CA, Adams AJ, Lewis RA. Automated perimetry of short-wavelength sensitive mechanisms in glaucoma and ocular hypertension: preliminary findings . In: Heijl A, ed. Perimetry Update 1988/89 . Amsterdam, the Netherlands: Kugler & Ghedini; 1989:31-37. 10. Johnson CA, Adams AJ, Lewis RA. Patterns of early glaucomatous visual field loss for short wavelength sensitive pathways . Invest Ophthalmol Vis Sci . 1989;30( (suppl) ):56. Abstract. 11. Adams AJ, Johnson CA, Lewis RA. S cone pathway sensitivity loss in ocular hypertension and early glaucoma has nerve fiber bundle pattern . In: Drum B, Moreland J, Serra A, eds. Proceedings of the 10th Symposium of the International Research Group on Colour Vision Deficiencies . The Hague, the Netherlands: Kluwer Academic Publishers; 1991:535-542. 12. Johnson CA, Adams AJ, Casson EJ, Nelson-Quigg JM. Can short wavelength sensitivity losses predict the development of glaucomatous visual field defects? In: Noninvasive Assessment of the Visual System . Washington, DC: Optical Society of America Technical Digest Series; 1991;1:2216-2219. 13. Sample PA, Weinreb RN. Progressive color visual field loss in glaucoma . Invest Ophthalmol Vis Sci . 1992;33:2068-2071. 14. Hart WM, Silverman SE, Trick GL, Nesher R, Gordon MO. Glaucomatous visual field damage: luminance and color-contrast sensitivities . Invest Ophthalmol Vis Sci . 1990;31:359-367. 15. Van Norren D, Vos JJ. Spectral transmission of the human ocular media . Vision Res . 1974;14:1237-1244.Crossref 16. Johnson CA, Adams AJ, Lewis RA. Evidence for a neural basis of age-related visual field loss in normal observers . Invest Ophthalmol Vis Sci . 1989;30:2056-2064. 17. Johnson CA, Adams AJ, Casson EJ, Brandt JD. Progression of early glaucomatous visual field loss for blue-on-yellow and standard white-on-white automated perimetry . Arch Ophthalmol . 1993;111:651-656.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Blue-on-Yellow Perimetry Can Predict the Development of Glaucomatous Visual Field Loss

Loading next page...
 
/lp/american-medical-association/blue-on-yellow-perimetry-can-predict-the-development-of-glaucomatous-raeykcJksO
Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1993.01090050079034
Publisher site
See Article on Publisher Site

Abstract

Abstract • Objective. —The purpose of this investigation was to determine whether blue-on-yellow (B/Y) perimetry is capable of predicting the onset and location of impending glaucomatous visual field loss in patients with ocular hypertension. Design. —A Humphrey Field Analyzer (Humphrey Instruments, San Leandro, Calif) was modified to perform B/Y perimetry to isolate and measure the sensitivity of short-wavelength—sensitive mechanisms. Participants were tested annually with standard white-on-white (W/W) and B/Y automated perimetry for a period of 5 years. Patients. —The study population consisted of 38 patients with ocular hypertension and 62 age-matched normal control subjects. Results. —Initially, all 76 ocular hypertensive eyes had normal W/W automated perimetry results, with 67 eyes having normal and nine eyes having abnormal B/Y test results. Five years later, five of the nine ocular hypertensive eyes with initial B/Y abnormal results developed glaucomatous visual field loss measured by standard W/W automated perimetry, while none of the 67 ocular hypertensive eyes with initially normal B/Y results developed abnormal W/W perimetry results. Conclusions. —Blue-on-yellow perimetry deficits are an early indicator of glaucomatous damage and are predictive of impending glaucomatous visual field loss for standard W/W automated perimetry. To our knowledge, this is the first prospective, long-term longitudinal study that demonstrates the ability to predict the onset of glaucomatous visual field loss in patients with ocular hypertension on the basis of psychophysical testing. References 1. Adams AJ, Heron G, Husted R. Clinical measures of central visual function in glaucoma and ocular hypertension . Arch Ophthalmol . 1987;105:782.Crossref 2. Adams AJ, Rodic R, Husted R, Stamper R. Spectral sensitivity and color discrimination changes in glaucoma and glaucoma-suspects . Invest Ophthalmol Vis Sci . 1982;23:516-524. 3. Sample PA, Weinreb RN, Boynton RM. Acquired dyschromatopsia in glaucoma . Surv Ophthalmol . 1986;31:54-64.Crossref 4. Drance SM, Lakowski R, Schulzer M, Douglas GR. Acquired color vision changes in glaucoma: use of 100-Hue Test and Pickford anomaloscope as predictors of glaucomatous field change . Arch Ophthalmol . 1981;99:829-831.Crossref 5. Heron G, Adams AJ, Husted R. Central visual fields for short wavelength sensitive pathways in glaucoma and ocular hypertension . Invest Ophthalmol Vis Sci . 1988;29:64-72. 6. Sample PA, Boynton R, Weinreb R. Isolating the color vision loss in primary open angle glaucoma . Am J Ophthalmol . 1988;106:686-691. 7. Sample PA, Weinreb RN. Color perimetry for assessment of primary open-angle glaucoma . Invest Ophthalmol Vis Sci . 1990;31:1869-1875. 8. Johnson CA, Adams AJ, Twelker JD, Quigg JM. Age related changes of the central visual field for short wavelength sensitive (SWS) pathways . J Opt Soc Am . 1988;5:2131-2139.Crossref 9. Johnson CA, Adams AJ, Lewis RA. Automated perimetry of short-wavelength sensitive mechanisms in glaucoma and ocular hypertension: preliminary findings . In: Heijl A, ed. Perimetry Update 1988/89 . Amsterdam, the Netherlands: Kugler & Ghedini; 1989:31-37. 10. Johnson CA, Adams AJ, Lewis RA. Patterns of early glaucomatous visual field loss for short wavelength sensitive pathways . Invest Ophthalmol Vis Sci . 1989;30( (suppl) ):56. Abstract. 11. Adams AJ, Johnson CA, Lewis RA. S cone pathway sensitivity loss in ocular hypertension and early glaucoma has nerve fiber bundle pattern . In: Drum B, Moreland J, Serra A, eds. Proceedings of the 10th Symposium of the International Research Group on Colour Vision Deficiencies . The Hague, the Netherlands: Kluwer Academic Publishers; 1991:535-542. 12. Johnson CA, Adams AJ, Casson EJ, Nelson-Quigg JM. Can short wavelength sensitivity losses predict the development of glaucomatous visual field defects? In: Noninvasive Assessment of the Visual System . Washington, DC: Optical Society of America Technical Digest Series; 1991;1:2216-2219. 13. Sample PA, Weinreb RN. Progressive color visual field loss in glaucoma . Invest Ophthalmol Vis Sci . 1992;33:2068-2071. 14. Hart WM, Silverman SE, Trick GL, Nesher R, Gordon MO. Glaucomatous visual field damage: luminance and color-contrast sensitivities . Invest Ophthalmol Vis Sci . 1990;31:359-367. 15. Van Norren D, Vos JJ. Spectral transmission of the human ocular media . Vision Res . 1974;14:1237-1244.Crossref 16. Johnson CA, Adams AJ, Lewis RA. Evidence for a neural basis of age-related visual field loss in normal observers . Invest Ophthalmol Vis Sci . 1989;30:2056-2064. 17. Johnson CA, Adams AJ, Casson EJ, Brandt JD. Progression of early glaucomatous visual field loss for blue-on-yellow and standard white-on-white automated perimetry . Arch Ophthalmol . 1993;111:651-656.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1993

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month