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BLOOD SUGAR IN A CASE OF COMPLETE HYPOPHYSECTOMY

BLOOD SUGAR IN A CASE OF COMPLETE HYPOPHYSECTOMY Abstract In this communication we shall show primarily that total removal of the pituitary body lowers the fasting blood sugar to a hypoglycemic level without shock and gives a delayed sugar tolerance curve, which may be a plateau at times. Furthermore, we shall show that the blood sugar level is not wholly dependent on the presence of this gland and that apparently the gland has not complete control over any vital function. Detailed reports of the surgical procedures employed by the neurosurgeons in the removal of a pituitary tumor and the inadvertent complete removal of the hypophysis are presented with the purpose of proving our contention that no pituitary tissue remained in this case. Our studies were considerably limited by the patient's extreme irritability and his hypersensitiveness to pain. A number of tests had to be interrupted because of the intense mental and physical reactions incurred. REPORT OF A CASE A. References 1. Boyd, W.: Physiology of the Pituitary Body , in A Textbook of Pathology , Philadelphia, Lea & Febiger, 1932, p. 704. 2. Towne, E. B.: The Pituitary Body , in Nelson New Loose-Leaf Medicine , New York, Thomas Nelson & Sons, 1938, vol. 3, pp. 239-256. 3. Cushing, H.: The Pituitary Body and Its Disorders , Philadelphia, J. B. Lippincott Company, 1912. 4. Van Dyke, W. E.: Physiology and Pharmacology of the Pituitary Body , Chicago, University of Chicago Press, 1936, pp. 1-56. 5. Dandy, W. E., and Reichert, F. L.: Experimental Hypophysectomy in Dogs , Bull. Johns Hopkins Hosp. 62:122-156, 1938 6. Studies on Experimental Hypophysectomy: Effect on the Maintenance of Life , Dandy Bull. Johns Hopkins Hosp. 37:1-13, 1925. 7. Baker, A. B., and Craft, C. B.: Bilateral Localized Lesions in the Hypothalamus with Complete Destruction of the Neurohypophysis in a Pituitary Dwarf with Severe Permanent Diabetes Insipidus , Endocrinology 26:801-807, 1940.Crossref 8. Hart, J. F., and Lisa, J.: The Rate of Occurrence of Hypoglycemia , Endocrinology 27:19-22, 1940.Crossref 9. Lawrence, R. D., and Hewlett, R. F. L.: Effect of Pituitrin and Insulin on Blood Sugar , Brit. M. J. 1:998-1002, 1925.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

BLOOD SUGAR IN A CASE OF COMPLETE HYPOPHYSECTOMY

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Publisher
American Medical Association
Copyright
Copyright © 1941 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1941.00200110045003
Publisher site
See Article on Publisher Site

Abstract

Abstract In this communication we shall show primarily that total removal of the pituitary body lowers the fasting blood sugar to a hypoglycemic level without shock and gives a delayed sugar tolerance curve, which may be a plateau at times. Furthermore, we shall show that the blood sugar level is not wholly dependent on the presence of this gland and that apparently the gland has not complete control over any vital function. Detailed reports of the surgical procedures employed by the neurosurgeons in the removal of a pituitary tumor and the inadvertent complete removal of the hypophysis are presented with the purpose of proving our contention that no pituitary tissue remained in this case. Our studies were considerably limited by the patient's extreme irritability and his hypersensitiveness to pain. A number of tests had to be interrupted because of the intense mental and physical reactions incurred. REPORT OF A CASE A. References 1. Boyd, W.: Physiology of the Pituitary Body , in A Textbook of Pathology , Philadelphia, Lea & Febiger, 1932, p. 704. 2. Towne, E. B.: The Pituitary Body , in Nelson New Loose-Leaf Medicine , New York, Thomas Nelson & Sons, 1938, vol. 3, pp. 239-256. 3. Cushing, H.: The Pituitary Body and Its Disorders , Philadelphia, J. B. Lippincott Company, 1912. 4. Van Dyke, W. E.: Physiology and Pharmacology of the Pituitary Body , Chicago, University of Chicago Press, 1936, pp. 1-56. 5. Dandy, W. E., and Reichert, F. L.: Experimental Hypophysectomy in Dogs , Bull. Johns Hopkins Hosp. 62:122-156, 1938 6. Studies on Experimental Hypophysectomy: Effect on the Maintenance of Life , Dandy Bull. Johns Hopkins Hosp. 37:1-13, 1925. 7. Baker, A. B., and Craft, C. B.: Bilateral Localized Lesions in the Hypothalamus with Complete Destruction of the Neurohypophysis in a Pituitary Dwarf with Severe Permanent Diabetes Insipidus , Endocrinology 26:801-807, 1940.Crossref 8. Hart, J. F., and Lisa, J.: The Rate of Occurrence of Hypoglycemia , Endocrinology 27:19-22, 1940.Crossref 9. Lawrence, R. D., and Hewlett, R. F. L.: Effect of Pituitrin and Insulin on Blood Sugar , Brit. M. J. 1:998-1002, 1925.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Nov 1, 1941

References