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Blood Pressure Thresholds During Endovascular Therapy in Ischemic Stroke

Blood Pressure Thresholds During Endovascular Therapy in Ischemic Stroke Letters AEDs were breastfeeding by comparing the percentage differ- tiple linear regression model, both of which proved to be non- ences of mothers’ AED blood concentrations with their re- significant. Therefore, with the currently available data, there spective infants’ AED blood concentrations. For lamotrigine, is no evidence that infant weight was a factor in the determi- infant-to-mother percentages had high variability between nation of drug exposure to the infant from the mother's milk. newborns, with concentrations ranging between 0.6% and 90.3%. Given that lamotrigine is likely a lipid-soluble Angela K. Birnbaum, PhD medication, we wonder if infants with higher body fat com- Kimford J. Meador, MD position (ie, infants who were large for gestational age), Page B. Pennell, MD compared with the infants who were normal or small for Author Affiliations: Department of Experimental and Clinical Pharmacology, gestational age, had a higher concentration of lamotrigine. If College of Pharmacy, University of Minnesota, Minneapolis (Birnbaum); the blood concentration of lamotrigine in infants who were Stanford University, Stanford, California (Meador); Brigham and Women's large for gestational age was significantly higher, the safety of Hospital, Harvard Medical School, Boston, Massachusetts (Pennell). breastfeeding in those infants should be evaluated more Corresponding Author: Angela http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Blood Pressure Thresholds During Endovascular Therapy in Ischemic Stroke

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Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/jamaneurol.2020.3816
Publisher site
See Article on Publisher Site

Abstract

Letters AEDs were breastfeeding by comparing the percentage differ- tiple linear regression model, both of which proved to be non- ences of mothers’ AED blood concentrations with their re- significant. Therefore, with the currently available data, there spective infants’ AED blood concentrations. For lamotrigine, is no evidence that infant weight was a factor in the determi- infant-to-mother percentages had high variability between nation of drug exposure to the infant from the mother's milk. newborns, with concentrations ranging between 0.6% and 90.3%. Given that lamotrigine is likely a lipid-soluble Angela K. Birnbaum, PhD medication, we wonder if infants with higher body fat com- Kimford J. Meador, MD position (ie, infants who were large for gestational age), Page B. Pennell, MD compared with the infants who were normal or small for Author Affiliations: Department of Experimental and Clinical Pharmacology, gestational age, had a higher concentration of lamotrigine. If College of Pharmacy, University of Minnesota, Minneapolis (Birnbaum); the blood concentration of lamotrigine in infants who were Stanford University, Stanford, California (Meador); Brigham and Women's large for gestational age was significantly higher, the safety of Hospital, Harvard Medical School, Boston, Massachusetts (Pennell). breastfeeding in those infants should be evaluated more Corresponding Author: Angela

Journal

JAMA NeurologyAmerican Medical Association

Published: Dec 12, 2020

References