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Blood Pressure in Sickle Cell Disease-Reply

Blood Pressure in Sickle Cell Disease-Reply Abstract Confirming reports of the unusual BP findings in patients with sickle cell disease have been published from Jamaica1 and now from the Netherlands. Although the explanation of these findings is unknown, this population represents an invaluable model for investigations into the pathophysiology of hypertension. The explanations that were offered in the June Archives (1981;141:891-894) were not meant to be definitive but to suggest hypotheses to be tested. As such, the comments of de Jong et al regarding the potential role of prostaglandins are welcomed additions. In regard to salt-losing nephropathy, the reply by Radel et al2 to the letter of DeFronzo and colleagues (de Jong reference 1) arguing for the presence of inappropriate ADH secretion in sickle cell anemia refutes this argument with additional data not included in the original report. Subsequently, DeFronzo et al3 showed that the kidney in sickle cell disease is vasopressin resistant. References 1. Grell GAC, Alleyne GAO, Serjeant GR: Blood pressure in adults with homozygous sickle cell disease. Lancet 1981;2:1166.Crossref 2. Radel EG, Kochen JA, Finberg L: More on the pathogenesis and management of hyponatremia in the crisis of sickle cell disease (reply). J Pediatr 1976;89:1039-1040.Crossref 3. DeFronzo RA, Taufield PA, Black H, et al: Impaired renal tubular potassium secretion in sickle cell disease. Ann Intern Med 1979;90:310-316.Crossref 4. Stuart MJ, Blinder E, Sills R: Abnormal vascular prostaglandin I2 (PGI2) synthesis in sickle cell anaemia. Read before the 18th meeting of the International Society of Haematology, Montreal, Aug 15-22, 1980. 5. Golub M, Speckart P, Zia P, et al: The effect of prostaglandin A, on renin and aldosterone in man. Circ Res 1976;39:574-579.Crossref 6. Statius van Eps LW, Pinedo-Veels C, de Vies GH, et al: Nature of concentrating defect in sickle-cell nephropathy. Lancet 1970;1:450-452.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Blood Pressure in Sickle Cell Disease-Reply

Archives of Internal Medicine , Volume 142 (6) – Jun 1, 1982

Blood Pressure in Sickle Cell Disease-Reply

Abstract

Abstract Confirming reports of the unusual BP findings in patients with sickle cell disease have been published from Jamaica1 and now from the Netherlands. Although the explanation of these findings is unknown, this population represents an invaluable model for investigations into the pathophysiology of hypertension. The explanations that were offered in the June Archives (1981;141:891-894) were not meant to be definitive but to suggest hypotheses to be tested. As such, the comments of de...
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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340190200037
Publisher site
See Article on Publisher Site

Abstract

Abstract Confirming reports of the unusual BP findings in patients with sickle cell disease have been published from Jamaica1 and now from the Netherlands. Although the explanation of these findings is unknown, this population represents an invaluable model for investigations into the pathophysiology of hypertension. The explanations that were offered in the June Archives (1981;141:891-894) were not meant to be definitive but to suggest hypotheses to be tested. As such, the comments of de Jong et al regarding the potential role of prostaglandins are welcomed additions. In regard to salt-losing nephropathy, the reply by Radel et al2 to the letter of DeFronzo and colleagues (de Jong reference 1) arguing for the presence of inappropriate ADH secretion in sickle cell anemia refutes this argument with additional data not included in the original report. Subsequently, DeFronzo et al3 showed that the kidney in sickle cell disease is vasopressin resistant. References 1. Grell GAC, Alleyne GAO, Serjeant GR: Blood pressure in adults with homozygous sickle cell disease. Lancet 1981;2:1166.Crossref 2. Radel EG, Kochen JA, Finberg L: More on the pathogenesis and management of hyponatremia in the crisis of sickle cell disease (reply). J Pediatr 1976;89:1039-1040.Crossref 3. DeFronzo RA, Taufield PA, Black H, et al: Impaired renal tubular potassium secretion in sickle cell disease. Ann Intern Med 1979;90:310-316.Crossref 4. Stuart MJ, Blinder E, Sills R: Abnormal vascular prostaglandin I2 (PGI2) synthesis in sickle cell anaemia. Read before the 18th meeting of the International Society of Haematology, Montreal, Aug 15-22, 1980. 5. Golub M, Speckart P, Zia P, et al: The effect of prostaglandin A, on renin and aldosterone in man. Circ Res 1976;39:574-579.Crossref 6. Statius van Eps LW, Pinedo-Veels C, de Vies GH, et al: Nature of concentrating defect in sickle-cell nephropathy. Lancet 1970;1:450-452.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jun 1, 1982

References