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Blood Histamine and Basophil-Eosinophil Counts in Skin Diseases

Blood Histamine and Basophil-Eosinophil Counts in Skin Diseases Abstract Shortly after histamine was first synthesized by Windaus and Vogt, in 1907,1 its physiologic properties were described by Dale and Laidlaw,2 who at the same time called attention to the similarity between the symptoms produced by administration of histamine and those of anaphylaxis. Later, Lewis3 observed that when stimuli of different kinds were applied to the skin, all elicited a common type of response, which he termed the "triple response." Noting the similarity between that response and histamine-induced wheals, he postulated that the triple response must be due to the liberation by injured cells of a histamine-like substance, which he called "H-substance." Much investigation has ensued in attempts to substantiate histamine as the chemical mediator of anaphylaxis in animals and of allergy in man. Since many dermatologic conditions are partially or totally allergic in origin, estimates have been made of the metabolism of histamine References 1. Windaus and Vogt, cited by Dale.2 2. Dale, H. H., and Laidlaw, P. P.: The Physiological Action of β-Iminazolylethylamine , J. Physiol. 41:318-344 ( (Dec. 31) ) 1910. 3. Lewis, T.: The Blood Vessels of the Human Skin and Their Responses , London, Shaw & Sons, 1927. 4. Capps, R. B., and Young, R. H.: Hypersensitivity to Light: Studies on an Unusual Case Treated Successfully with Histamine , J. Clin. Invest. 19:778-779 ( (Sept.) ) 1940. 5. Cerqua, S., cited by Rose.12 6. El-Sayed, M. F. A.: Estimation of Blood Histamine in Allergic Skin Diseases , J. Roy. Egyptian M. A. 33:810-818, 1950. 7. Gate, J.; Pellerat, J.; Badel, M., and Murat, M.: Recherches sur l'histaminémie: L'Histaminurie en dermatologie et le taux physiologique de l'histamine cutanée , Compt. rend. Soc. biol. 138:542-544 ( (Jan. 17) ) 1944. 8. Mitumoto, S.: Histamingehalt im Blut und Harn bei Hautkrankheiten , Jap. J. Dermat. & Urol. 49:25-26 ( (March 20) ) 1941. 9. Nilzén, Å.: Studies in Histamine (H-Substance) with Special Reference to the Conditions Obtaining in Urticaria and Related Skin-Changes , Acta dermat.-venereol. ( (Supp. 17) ) 27:1-68, 1947. 10. Nilzén, Å.: Blood Histamine and Arsphenamine Dermatitis , Acta dermat.-venereol. 27:521-527, 1947. 11. Rose, B.: Studies on Blood Histamine in Cases of Allergy: I. Blood Histamine During Wheal Formation , J. Allergy 12:327-334 ( (May) ) 1941. 12. Rose, B.: Studies of Blood Histamine in Patients with Allergy: II. Alterations in the Blood Histamine in Patients with Allergic Disease , J. Clin. Invest. 20:419-428 ( (July) ) 1941. 13. Tarras-Wahlberg, B.: Blood Histamine in Salvarsan-Dermatitis , Acta dermat.-venereol. 18: 284-292 ( (June) ) 1937. 14. Code, C. F.: The Source in Blood of the Histamine-like Constituent , J. Physiol. 90:349-364 ( (Aug.) ) 1937. 15. Code, C. F.: The Histamine-like Activity of White Blood Cells , J. Physiol. 90:485-500 ( (Sept.) ) 1937. 16. Code, C. F.: Histamine in Blood , Physiol. Rev. 32:47-65 ( (Jan.) ) 1952. 17. Code, C. F.: Discussion, in Ciba Foundation Symposium Jointly with the Physiological Society and the British Pharmacological Society on Histamine , edited by G. E. W. Wolstenholme and C. O'Conner, Boston, Little, Brown & Company, 1956, pp. 412-413. 18. Code, C. F., and Mitchell, R. G.: Cited by Code.17 19. Code, C. F.; Mitchell, R. G., and Kennedy, J. C.: The Effect of Cortisone on the Number of Circulating Basophils and Eosinophils: Is There a Relationship Between These Cells? Proc. Staff Meet. Mayo Clin. 29:200-204 ( (April 7) ) 1954. 20. Osada, Y.: Parallel Changes in the Numbers of Circulating Eosinophils and Basophils Induced by ACTH Administration , Bull. Inst. Publ. Hlth., Tokyo 4:12-18 ( (Sept.) ) 1954. 21. Hamerston, O.; Elveback, L.; Halberg, F., and Gully, R. J.: Correlation of Absolute Basophil and Eosinophil Counts in Blood from Institutionalized Human Subjects , J. Appl. Physiol. 9:205-207 ( (Sept.) ) 1956. 22. Graham, H. T.; Lowry, O. H.; Wheelwright, F.; Lenz, M. A., and Parish, H. H., Jr.: Distribution of Histamine Among Leukocytes and Platelets , Blood 10:467-481 ( (May) ) 1955. 23. Rose, B.: Histamine, Hormones and Hypersensitivity , in Recent Progress in Hormone Research , edited by G. Pincus, New York, Academic Press, Inc., Vol. 7, 1952, p. 377. 24. Valentine, W. N.; Lawrence, J. S.; Pearce, M. L., and Beck, W. S.: The Relationship of the Basophil to Blood Histamine in Man , Blood 10:154-159 ( (Feb.) ) 1955. 25. Valentine, W. N.: The Enzymes of Leukocytes , Ann. New York Acad. Sc. 59:1003-1011 ( (March) ) 1955. 26. Randolph, T. G.: Blood Studies in Allergy: I. The Direct Counting Chamber Determination of Eosinophils by Propylene Glycol Aqueous Stains , J. Allergy 15:89-96 ( (March) ) 1944. 27. Moore, J. E., III, and James, G. W., III: A Simple Direct Method for Absolute Basophil Leukocyte Count , Proc. Soc. Exper. Biol. & Med. 82:601-603 ( (April) ) 1953. 28. Code, C. F.: The Quantitative Estimation of Histamine in the Blood , J. Physiol. 89:257-268 ( (April) ) 1937. 29. Sturgis, C. C.: Hematology , Ed. 2, Springfield, Ill., Charles C Thomas, Publisher, 1955, p. 734. 30. Baer, R. L.: Atopic Dermatitis , Philadelphia, J. B. Lippincott Company, 1955. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Blood Histamine and Basophil-Eosinophil Counts in Skin Diseases

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1959.01560190046006
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Abstract

Abstract Shortly after histamine was first synthesized by Windaus and Vogt, in 1907,1 its physiologic properties were described by Dale and Laidlaw,2 who at the same time called attention to the similarity between the symptoms produced by administration of histamine and those of anaphylaxis. Later, Lewis3 observed that when stimuli of different kinds were applied to the skin, all elicited a common type of response, which he termed the "triple response." Noting the similarity between that response and histamine-induced wheals, he postulated that the triple response must be due to the liberation by injured cells of a histamine-like substance, which he called "H-substance." Much investigation has ensued in attempts to substantiate histamine as the chemical mediator of anaphylaxis in animals and of allergy in man. Since many dermatologic conditions are partially or totally allergic in origin, estimates have been made of the metabolism of histamine References 1. Windaus and Vogt, cited by Dale.2 2. Dale, H. H., and Laidlaw, P. P.: The Physiological Action of β-Iminazolylethylamine , J. Physiol. 41:318-344 ( (Dec. 31) ) 1910. 3. Lewis, T.: The Blood Vessels of the Human Skin and Their Responses , London, Shaw & Sons, 1927. 4. Capps, R. B., and Young, R. H.: Hypersensitivity to Light: Studies on an Unusual Case Treated Successfully with Histamine , J. Clin. Invest. 19:778-779 ( (Sept.) ) 1940. 5. Cerqua, S., cited by Rose.12 6. El-Sayed, M. F. A.: Estimation of Blood Histamine in Allergic Skin Diseases , J. Roy. Egyptian M. A. 33:810-818, 1950. 7. Gate, J.; Pellerat, J.; Badel, M., and Murat, M.: Recherches sur l'histaminémie: L'Histaminurie en dermatologie et le taux physiologique de l'histamine cutanée , Compt. rend. Soc. biol. 138:542-544 ( (Jan. 17) ) 1944. 8. Mitumoto, S.: Histamingehalt im Blut und Harn bei Hautkrankheiten , Jap. J. Dermat. & Urol. 49:25-26 ( (March 20) ) 1941. 9. Nilzén, Å.: Studies in Histamine (H-Substance) with Special Reference to the Conditions Obtaining in Urticaria and Related Skin-Changes , Acta dermat.-venereol. ( (Supp. 17) ) 27:1-68, 1947. 10. Nilzén, Å.: Blood Histamine and Arsphenamine Dermatitis , Acta dermat.-venereol. 27:521-527, 1947. 11. Rose, B.: Studies on Blood Histamine in Cases of Allergy: I. Blood Histamine During Wheal Formation , J. Allergy 12:327-334 ( (May) ) 1941. 12. Rose, B.: Studies of Blood Histamine in Patients with Allergy: II. Alterations in the Blood Histamine in Patients with Allergic Disease , J. Clin. Invest. 20:419-428 ( (July) ) 1941. 13. Tarras-Wahlberg, B.: Blood Histamine in Salvarsan-Dermatitis , Acta dermat.-venereol. 18: 284-292 ( (June) ) 1937. 14. Code, C. F.: The Source in Blood of the Histamine-like Constituent , J. Physiol. 90:349-364 ( (Aug.) ) 1937. 15. Code, C. F.: The Histamine-like Activity of White Blood Cells , J. Physiol. 90:485-500 ( (Sept.) ) 1937. 16. Code, C. F.: Histamine in Blood , Physiol. Rev. 32:47-65 ( (Jan.) ) 1952. 17. Code, C. F.: Discussion, in Ciba Foundation Symposium Jointly with the Physiological Society and the British Pharmacological Society on Histamine , edited by G. E. W. Wolstenholme and C. O'Conner, Boston, Little, Brown & Company, 1956, pp. 412-413. 18. Code, C. F., and Mitchell, R. G.: Cited by Code.17 19. Code, C. F.; Mitchell, R. G., and Kennedy, J. C.: The Effect of Cortisone on the Number of Circulating Basophils and Eosinophils: Is There a Relationship Between These Cells? Proc. Staff Meet. Mayo Clin. 29:200-204 ( (April 7) ) 1954. 20. Osada, Y.: Parallel Changes in the Numbers of Circulating Eosinophils and Basophils Induced by ACTH Administration , Bull. Inst. Publ. Hlth., Tokyo 4:12-18 ( (Sept.) ) 1954. 21. Hamerston, O.; Elveback, L.; Halberg, F., and Gully, R. J.: Correlation of Absolute Basophil and Eosinophil Counts in Blood from Institutionalized Human Subjects , J. Appl. Physiol. 9:205-207 ( (Sept.) ) 1956. 22. Graham, H. T.; Lowry, O. H.; Wheelwright, F.; Lenz, M. A., and Parish, H. H., Jr.: Distribution of Histamine Among Leukocytes and Platelets , Blood 10:467-481 ( (May) ) 1955. 23. Rose, B.: Histamine, Hormones and Hypersensitivity , in Recent Progress in Hormone Research , edited by G. Pincus, New York, Academic Press, Inc., Vol. 7, 1952, p. 377. 24. Valentine, W. N.; Lawrence, J. S.; Pearce, M. L., and Beck, W. S.: The Relationship of the Basophil to Blood Histamine in Man , Blood 10:154-159 ( (Feb.) ) 1955. 25. Valentine, W. N.: The Enzymes of Leukocytes , Ann. New York Acad. Sc. 59:1003-1011 ( (March) ) 1955. 26. Randolph, T. G.: Blood Studies in Allergy: I. The Direct Counting Chamber Determination of Eosinophils by Propylene Glycol Aqueous Stains , J. Allergy 15:89-96 ( (March) ) 1944. 27. Moore, J. E., III, and James, G. W., III: A Simple Direct Method for Absolute Basophil Leukocyte Count , Proc. Soc. Exper. Biol. & Med. 82:601-603 ( (April) ) 1953. 28. Code, C. F.: The Quantitative Estimation of Histamine in the Blood , J. Physiol. 89:257-268 ( (April) ) 1937. 29. Sturgis, C. C.: Hematology , Ed. 2, Springfield, Ill., Charles C Thomas, Publisher, 1955, p. 734. 30. Baer, R. L.: Atopic Dermatitis , Philadelphia, J. B. Lippincott Company, 1955.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1959

References