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BLOOD COAGULATION IN DISSEMINATED SCLEROSIS AND OTHER DISEASES OF BRAIN STEM AND CORD

BLOOD COAGULATION IN DISSEMINATED SCLEROSIS AND OTHER DISEASES OF BRAIN STEM AND CORD Abstract In 1935 Simon and Solomon1 published studies on the coagulation responses of the blood in disseminated sclerosis. Their theoretic considerations sprang from the observations of many workers2 that exacerbations of symptoms in disseminated sclerosis are often related to trauma, operation, exposure, immersion, pregnancy, infection, emotional excitement, etc.—factors cited by Pickering3 as predisposing to disturbances in the blood plasma and to thrombosis. The hypothesis that a common denominator in these situations might be a disturbance in the coagulation reactions of the blood offers a clinical basis for the observations of Putnam and associates4 that the lesions in disseminated sclerosis are the result of venous thromboses in the brain and spinal cord. Simon and Solomon1a found that in both control cases and cases of disseminated sclerosis there was a definite drop in coagulation time after the intravenous administration of typhoid vaccine. They observed, also, a similar, but References 1. Simon, B., and Solomon, P.: Multiple Sclerosis: Effect of Typhoid Vaccine and of Epinephrine on Coagulation of the Blood , Arch. Neurol. & Psychiat. 34: 1286 ( (Dec.) ) 1935. 2. Solomon, P., and Simon, B.: The Blood Coagulation in Cases of Multiple Sclerosis , Arch. Neurol. & Psychiat. 33:1383 ( (June) ) 1935. 3. Berger, A.: Eine Statistik über 206 Fälle von multipler Sklerose , Jahrb. f. Psychiat. u. Neurol. 25:168, 1905. 4. Jelliffe, S. E.: Multiple Sclerosis: Its Occurrence and Etiology , J. Nerv. & Ment. Dis. 31:446, 1904. 5. Marie, P.: Sclérose en plaques et maladies infectieuses , Progrès méd. 12:287, 305, 349 and 365, 1884. 6. Oppenheim, H.: Aerztliches Gutachten betreffend die Erkältungs-Aetiologie der multiplen Sklerose , Med. Klin. 7:1517, 1911. 7. Palmer, W. T.: Case of Disseminated Sclerosis Following Injury , West London M. J. 12:219, 1907. 8. Woodbury, M. S.: A Probable Etiologic Factor in Multiple Sclerosis , Arch. Neurol. & Psychiat. 1:408 ( (April) ) 1919. 9. Pickering, J. W.: The Blood Plasma in Health and Disease , New York, The Macmillan Company, 1928. 10. Putnam, T. J.; McKenna, J. B., and Morrison, L. R.: Studies in Multiple Sclerosis: I. The Histogenesis of Experimental Sclerotic Plaques and Their Relation to Multiple Sclerosis , J. A. M. A. 97:1591 ( (Nov. 28) ) 1931. 11. Putnam, T. J.; McKenna, J. B., and Evans, J.: Experimental Multiple Sclerosis in Dogs from Injection of Tetanous Toxin , J. f. Psychol. u. Neurol. 44:460, 1932. 12. Putnam, T. J.: Pathogenesis of Multiple Sclerosis , New England J. Med. 209:786 ( (Sept. 7) ) 1933 13. The Biological Significance of the Lesions of Multiple Sclerosis , Science 80:295 ( (Sept. 28) ) 1934 14. Studies in Multiple Sclerosis: IV. "Encephalitis" and Sclerotic Plaques Produced by Venular Obstruction , Arch. Neurol. & Psychiat. 33:929 ( (May) ) 1935. 15. Putnam, T. J.: Studies in Multiple Sclerosis: VIII. Etiologic Factors in Multiple Sclerosis , Ann. Int. Med. 9:854 ( (Jan.) ) 1936. 16. Putnam, T. J., and Adler, A.: Vascular Architecture of the Lesions of Multiple Sclerosis , Arch. Neurol. & Psychiat. 38:1 ( (July) ) 1937. 17. Putnam, T. J.: Lesions of "Encephalomyelitis" and Multiple Sclerosis , J. A. M. A. 108:1477 ( (May 1) ) 1937. 18. Putnam, T. J.: Evidences of Vascular Occlusion in Multiple Sclerosis and "Encephalomyelitis," Arch. Neurol. & Psychiat. 37:1298 ( (June) ) 1937. 19. Alexander, L., and Myerson, A.: The Mineral Content in Cerebral Lesions , J. Nerv. & Ment. Dis. 84:313 ( (Sept.) ) 1936. 20. Cannon, W. B.: Bodily Changes in Pain, Hunger, Fear and Rage , New York, D. Appleton and Company, 1929, chaps. 9 and 10 . 21. Haug, K.: Leberfunktionsprüfungen bei multipler Sklerose , Monatschr. f. Psychiat. u. Neurol. 88:225 ( (April) ) 1934. 22. Koch, C. F., and de Savitsch, E.: Surgical Treatment of Disseminated Sclerosis by Sympathectomy and Ganglionectomy , Brit. M. J. 1:1254 ( (June 11) ) 1938. 23. Weil, A., and Cleveland, D.: A Serologic Study of Multiple Sclerosis , Arch. Neurol. & Psychiat. 27:375 ( (Feb.) ) 1932. 24. Brickner, R. M.: Recent Experimental Work on the Pathogenesis of Multiple Sclerosis , J. A. M. A. 106:2117 ( (Jan. 20) ) 1936. 25. Brickner, R. M., and Brill, N. Q.: Dietetic and Related Studies on Multiple Sclerosis , Arch. Neurol. & Psychiat. 46:16 ( (July) ) 1941. 26. Rhodes, A. J.: Disseminated Sclerosis: A Review of Modern Work on Its Aetiology , Edinburgh M. J. 46:581 ( (Sept.) ) 1939. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

BLOOD COAGULATION IN DISSEMINATED SCLEROSIS AND OTHER DISEASES OF BRAIN STEM AND CORD

Archives of Neurology & Psychiatry , Volume 48 (4) – Oct 1, 1942

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Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1942.02290100009001
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Abstract

Abstract In 1935 Simon and Solomon1 published studies on the coagulation responses of the blood in disseminated sclerosis. Their theoretic considerations sprang from the observations of many workers2 that exacerbations of symptoms in disseminated sclerosis are often related to trauma, operation, exposure, immersion, pregnancy, infection, emotional excitement, etc.—factors cited by Pickering3 as predisposing to disturbances in the blood plasma and to thrombosis. The hypothesis that a common denominator in these situations might be a disturbance in the coagulation reactions of the blood offers a clinical basis for the observations of Putnam and associates4 that the lesions in disseminated sclerosis are the result of venous thromboses in the brain and spinal cord. Simon and Solomon1a found that in both control cases and cases of disseminated sclerosis there was a definite drop in coagulation time after the intravenous administration of typhoid vaccine. They observed, also, a similar, but References 1. Simon, B., and Solomon, P.: Multiple Sclerosis: Effect of Typhoid Vaccine and of Epinephrine on Coagulation of the Blood , Arch. Neurol. & Psychiat. 34: 1286 ( (Dec.) ) 1935. 2. Solomon, P., and Simon, B.: The Blood Coagulation in Cases of Multiple Sclerosis , Arch. Neurol. & Psychiat. 33:1383 ( (June) ) 1935. 3. Berger, A.: Eine Statistik über 206 Fälle von multipler Sklerose , Jahrb. f. Psychiat. u. Neurol. 25:168, 1905. 4. Jelliffe, S. E.: Multiple Sclerosis: Its Occurrence and Etiology , J. Nerv. & Ment. Dis. 31:446, 1904. 5. Marie, P.: Sclérose en plaques et maladies infectieuses , Progrès méd. 12:287, 305, 349 and 365, 1884. 6. Oppenheim, H.: Aerztliches Gutachten betreffend die Erkältungs-Aetiologie der multiplen Sklerose , Med. Klin. 7:1517, 1911. 7. Palmer, W. T.: Case of Disseminated Sclerosis Following Injury , West London M. J. 12:219, 1907. 8. Woodbury, M. S.: A Probable Etiologic Factor in Multiple Sclerosis , Arch. Neurol. & Psychiat. 1:408 ( (April) ) 1919. 9. Pickering, J. W.: The Blood Plasma in Health and Disease , New York, The Macmillan Company, 1928. 10. Putnam, T. J.; McKenna, J. B., and Morrison, L. R.: Studies in Multiple Sclerosis: I. The Histogenesis of Experimental Sclerotic Plaques and Their Relation to Multiple Sclerosis , J. A. M. A. 97:1591 ( (Nov. 28) ) 1931. 11. Putnam, T. J.; McKenna, J. B., and Evans, J.: Experimental Multiple Sclerosis in Dogs from Injection of Tetanous Toxin , J. f. Psychol. u. Neurol. 44:460, 1932. 12. Putnam, T. J.: Pathogenesis of Multiple Sclerosis , New England J. Med. 209:786 ( (Sept. 7) ) 1933 13. The Biological Significance of the Lesions of Multiple Sclerosis , Science 80:295 ( (Sept. 28) ) 1934 14. Studies in Multiple Sclerosis: IV. "Encephalitis" and Sclerotic Plaques Produced by Venular Obstruction , Arch. Neurol. & Psychiat. 33:929 ( (May) ) 1935. 15. Putnam, T. J.: Studies in Multiple Sclerosis: VIII. Etiologic Factors in Multiple Sclerosis , Ann. Int. Med. 9:854 ( (Jan.) ) 1936. 16. Putnam, T. J., and Adler, A.: Vascular Architecture of the Lesions of Multiple Sclerosis , Arch. Neurol. & Psychiat. 38:1 ( (July) ) 1937. 17. Putnam, T. J.: Lesions of "Encephalomyelitis" and Multiple Sclerosis , J. A. M. A. 108:1477 ( (May 1) ) 1937. 18. Putnam, T. J.: Evidences of Vascular Occlusion in Multiple Sclerosis and "Encephalomyelitis," Arch. Neurol. & Psychiat. 37:1298 ( (June) ) 1937. 19. Alexander, L., and Myerson, A.: The Mineral Content in Cerebral Lesions , J. Nerv. & Ment. Dis. 84:313 ( (Sept.) ) 1936. 20. Cannon, W. B.: Bodily Changes in Pain, Hunger, Fear and Rage , New York, D. Appleton and Company, 1929, chaps. 9 and 10 . 21. Haug, K.: Leberfunktionsprüfungen bei multipler Sklerose , Monatschr. f. Psychiat. u. Neurol. 88:225 ( (April) ) 1934. 22. Koch, C. F., and de Savitsch, E.: Surgical Treatment of Disseminated Sclerosis by Sympathectomy and Ganglionectomy , Brit. M. J. 1:1254 ( (June 11) ) 1938. 23. Weil, A., and Cleveland, D.: A Serologic Study of Multiple Sclerosis , Arch. Neurol. & Psychiat. 27:375 ( (Feb.) ) 1932. 24. Brickner, R. M.: Recent Experimental Work on the Pathogenesis of Multiple Sclerosis , J. A. M. A. 106:2117 ( (Jan. 20) ) 1936. 25. Brickner, R. M., and Brill, N. Q.: Dietetic and Related Studies on Multiple Sclerosis , Arch. Neurol. & Psychiat. 46:16 ( (July) ) 1941. 26. Rhodes, A. J.: Disseminated Sclerosis: A Review of Modern Work on Its Aetiology , Edinburgh M. J. 46:581 ( (Sept.) ) 1939.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Oct 1, 1942

References