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BLOOD CHOLINE ESTERASE IN MYOTONIA CONGENITA AND MYASTHENIA GRAVIS

BLOOD CHOLINE ESTERASE IN MYOTONIA CONGENITA AND MYASTHENIA GRAVIS Abstract Considerable interest has arisen concerning the role of cholinergic substances in myotonia congenita and myasthenia gravis. This has been stimulated by the recognition of the important part played by acetylcholine as a chemical transmitter of the parasympathetic impulses1 and the demonstration of a specific blood esterase for its destruction.2 It has been suggested that in myotonia there is an excess production of acetylcholine or an insufficient amount of esterase and that in myasthenia there is an insufficient amount of acetylcholine or an increase in esterase. Kennedy and Wolf3 reviewed the evidence for and against these conceptions and concluded that neither adequately accounts for the facts; they suggested that the acidity of the muscle due to some metabolic disturbance may be changed sufficiently to affect the action of acetylcholine. Determinations of values for acetylcholine esterase in the blood in cases of myasthenia gravis have given conflicting results. Stedman References 1. Brown, G. L.; Dale, H. H., and Feldberg, W.: Reactions of the Normal Mammalian Muscle to Acetylcholine and to Eserine , J. Physiol. 87:394-424 ( (Sept. 8) ) 1936. 2. Stedman, Edgar; Stedman, Ellen, and White, A. C.: A Comparison of the Choline-Esterase Activities of the Blood-Sera from Various Species , Biochem. J. 27:1055-1060, 1933. 3. Kennedy, F., and Wolf, A.: Quinine in Myotonia and Prostigmin in Myasthenia , J. A. M. A. 110:198-201 ( (Jan. 15) ) 1938.Crossref 4. Stedman, E.: The Choline Esterase Content of Blood in Myasthenia Gravis , J. Physiol. 84:561 ( (July) ) 1935. 5. McGeorge, M.: Choline Esterase Activity in Disease, with Special Reference to Myasthenia Gravis , Lancet 1:69-72 ( (Jan. 9) ) 1937.Crossref 6. Hicks, C. S., and MacKay, M. E.: The Choline-Esterase Activity of Blood Serum from Two Cases of Myasthenia Gravis , Australian J. Exper. Biol. & M. Sc. 14:275-289 ( (Dec.) ) 1936. 7. Hicks, C. S., and MacKay, M. E.: The Cholinesterase Content of Blood Sera from Normal and Myopathic Subjects , Australian J. Exper. Biol. & M. Sc. 16:39-51 ( (March) ) 1938. 8. Hall, G. E., and Lucas, C. C.: Choline-Esterase Activity of Normal and Pathological Human Sera , J. Pharmacol. & Exper. Therap. 59:34-41 ( (Jan.) ) 1937. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

BLOOD CHOLINE ESTERASE IN MYOTONIA CONGENITA AND MYASTHENIA GRAVIS

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Publisher
American Medical Association
Copyright
Copyright © 1939 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1939.02270180055004
Publisher site
See Article on Publisher Site

Abstract

Abstract Considerable interest has arisen concerning the role of cholinergic substances in myotonia congenita and myasthenia gravis. This has been stimulated by the recognition of the important part played by acetylcholine as a chemical transmitter of the parasympathetic impulses1 and the demonstration of a specific blood esterase for its destruction.2 It has been suggested that in myotonia there is an excess production of acetylcholine or an insufficient amount of esterase and that in myasthenia there is an insufficient amount of acetylcholine or an increase in esterase. Kennedy and Wolf3 reviewed the evidence for and against these conceptions and concluded that neither adequately accounts for the facts; they suggested that the acidity of the muscle due to some metabolic disturbance may be changed sufficiently to affect the action of acetylcholine. Determinations of values for acetylcholine esterase in the blood in cases of myasthenia gravis have given conflicting results. Stedman References 1. Brown, G. L.; Dale, H. H., and Feldberg, W.: Reactions of the Normal Mammalian Muscle to Acetylcholine and to Eserine , J. Physiol. 87:394-424 ( (Sept. 8) ) 1936. 2. Stedman, Edgar; Stedman, Ellen, and White, A. C.: A Comparison of the Choline-Esterase Activities of the Blood-Sera from Various Species , Biochem. J. 27:1055-1060, 1933. 3. Kennedy, F., and Wolf, A.: Quinine in Myotonia and Prostigmin in Myasthenia , J. A. M. A. 110:198-201 ( (Jan. 15) ) 1938.Crossref 4. Stedman, E.: The Choline Esterase Content of Blood in Myasthenia Gravis , J. Physiol. 84:561 ( (July) ) 1935. 5. McGeorge, M.: Choline Esterase Activity in Disease, with Special Reference to Myasthenia Gravis , Lancet 1:69-72 ( (Jan. 9) ) 1937.Crossref 6. Hicks, C. S., and MacKay, M. E.: The Choline-Esterase Activity of Blood Serum from Two Cases of Myasthenia Gravis , Australian J. Exper. Biol. & M. Sc. 14:275-289 ( (Dec.) ) 1936. 7. Hicks, C. S., and MacKay, M. E.: The Cholinesterase Content of Blood Sera from Normal and Myopathic Subjects , Australian J. Exper. Biol. & M. Sc. 16:39-51 ( (March) ) 1938. 8. Hall, G. E., and Lucas, C. C.: Choline-Esterase Activity of Normal and Pathological Human Sera , J. Pharmacol. & Exper. Therap. 59:34-41 ( (Jan.) ) 1937.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Jun 1, 1939

References