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Black Urine

Black Urine To the Editor.— Dr. Leonard B. Berman's article, "Urine in Technicolor" (228:753, 1974), states: "For example, the massive hemolysis associated with falciparum malaria produces black urine, whence the name blackwater fever arises." In the journal Drug Therapy of April 1974, an article entitled "Patient Factors Governing Response to Drugs," by Dr. Peter Goldman, observes that genetic factors can determine an individual's response to drugs, and that differences are noted in dramatic side effects. Thus, "blackwater fever," a term which describes the presence of heme in the urine resulting from severe hemolysis, was found to occur in response to certain drugs. This condition is now known to be caused by alterations in the function of glucose-6phosphate dehydrogenase of the red blood cells of these patients. Apparently this single enzyme defect is responsible for the altered drug response which is found mainly in people who are black or of Mediterranean origin. Thus, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Black Urine

JAMA , Volume 229 (12) – Sep 16, 1974

Black Urine

Abstract



To the Editor.—
Dr. Leonard B. Berman's article, "Urine in Technicolor" (228:753, 1974), states: "For example, the massive hemolysis associated with falciparum malaria produces black urine, whence the name blackwater fever arises."
In the journal Drug Therapy of April 1974, an article entitled "Patient Factors Governing Response to Drugs," by Dr. Peter Goldman, observes that genetic factors can determine an individual's response to drugs, and...
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Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1974.03230500016013
Publisher site
See Article on Publisher Site

Abstract

To the Editor.— Dr. Leonard B. Berman's article, "Urine in Technicolor" (228:753, 1974), states: "For example, the massive hemolysis associated with falciparum malaria produces black urine, whence the name blackwater fever arises." In the journal Drug Therapy of April 1974, an article entitled "Patient Factors Governing Response to Drugs," by Dr. Peter Goldman, observes that genetic factors can determine an individual's response to drugs, and that differences are noted in dramatic side effects. Thus, "blackwater fever," a term which describes the presence of heme in the urine resulting from severe hemolysis, was found to occur in response to certain drugs. This condition is now known to be caused by alterations in the function of glucose-6phosphate dehydrogenase of the red blood cells of these patients. Apparently this single enzyme defect is responsible for the altered drug response which is found mainly in people who are black or of Mediterranean origin. Thus,

Journal

JAMAAmerican Medical Association

Published: Sep 16, 1974

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