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BISMUTH SUBNITRATE IN THE TREATMENT OF ARTERIAL HYPERTENSION

BISMUTH SUBNITRATE IN THE TREATMENT OF ARTERIAL HYPERTENSION Curative therapy must be based on etiology. The etiology of arterial hypertension is complex; anything that irritates the arteriolar musculature or stimulates the sympathetic pressor fibers may represent the original cause of hypertensive vascular disease. These irritants are many;1 endocrine disturbances, dietary irritants, infections, intoxications with metals or chemical irritants, anemia and predisposition to early fatigue of the vascular structures represent some of the known factors. These factors may be spoken of as "initiating factors." In addition, the arteriolar disease of hypertension tends to perpetuate itself even if the irritative factors are no longer operative.2 The pathogenesis of hypertension may be best visualized from the diagram. The perpetuating factor is the vicious circle of vascular spasticity causing muscular fatigue, the fatigue leading to increasing arteriolar irritability, and in turn more spasticity and fatigue. Fatigue is amenable to rest; exhaustion, muscular degeneration and fibrosis are irreparable.1 Clinical experience http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

BISMUTH SUBNITRATE IN THE TREATMENT OF ARTERIAL HYPERTENSION

JAMA , Volume 95 (12) – Sep 20, 1930

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References (16)

Publisher
American Medical Association
Copyright
Copyright © 1930 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1930.02720120010004
Publisher site
See Article on Publisher Site

Abstract

Curative therapy must be based on etiology. The etiology of arterial hypertension is complex; anything that irritates the arteriolar musculature or stimulates the sympathetic pressor fibers may represent the original cause of hypertensive vascular disease. These irritants are many;1 endocrine disturbances, dietary irritants, infections, intoxications with metals or chemical irritants, anemia and predisposition to early fatigue of the vascular structures represent some of the known factors. These factors may be spoken of as "initiating factors." In addition, the arteriolar disease of hypertension tends to perpetuate itself even if the irritative factors are no longer operative.2 The pathogenesis of hypertension may be best visualized from the diagram. The perpetuating factor is the vicious circle of vascular spasticity causing muscular fatigue, the fatigue leading to increasing arteriolar irritability, and in turn more spasticity and fatigue. Fatigue is amenable to rest; exhaustion, muscular degeneration and fibrosis are irreparable.1 Clinical experience

Journal

JAMAAmerican Medical Association

Published: Sep 20, 1930

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