Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Biological Activity of Calcitriol

Biological Activity of Calcitriol Abstract Sir.—I read with interest the article by Venkataraman et al1 in the October issue of AJDC. After reading their explanations and examining Fig 2, which did not indicate any dose-dependent calcium response to parenteral administration of 1,25-dihydroxyvitamin D, I wonder about the biological activity of the calcitriol that the authors used. I was also struck that the parathyroid hormone levels of the infants did not seem to respond at all to hypocalcemia, although markedly low calcium levels (such as 1.01 mmol/L [4.03 mg/dL]) were recorded. There was also no mention of the observation of tetany in these infants. These findings may suggest the inhibition of parathyroid hormone secretion in these infants, as is observed with administration of ethiofos (WR 2721),2 or acceptance of early neonatal hypocalcemia as a physiologic phenomenon that does not require treatment, as proposed by Scott et al.3 However, the determination of ionized References 1. Venkataraman PS, Tsang RC, Steichen JJ, et al: Early neonatal hypocalcemia in extremely preterm infants: High incidence, early onset, and refractoriness to supraphysiologic doses of calcitriol . AJDC 1986;140:1004-1008. 2. Glover D, Riley L, Carmichael K, et al: Hypocalcemia and inhibition of parathyroid hormone secretion after administration of WR-2721 (a radioprotective and chemoprotective agent) . N Engl J Med 1983;309:1137-1141.Crossref 3. Scott SM, Ladenson JH, Aguanna JJ, et al: Effect of calcium therapy in the sick premature infant with early neonatal hypocalcemia . J Pediatr 1984;104:747-751.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Biological Activity of Calcitriol

Biological Activity of Calcitriol

Abstract

Abstract Sir.—I read with interest the article by Venkataraman et al1 in the October issue of AJDC. After reading their explanations and examining Fig 2, which did not indicate any dose-dependent calcium response to parenteral administration of 1,25-dihydroxyvitamin D, I wonder about the biological activity of the calcitriol that the authors used. I was also struck that the parathyroid hormone levels of the infants did not seem to respond at all to hypocalcemia, although markedly low...
Loading next page...
 
/lp/american-medical-association/biological-activity-of-calcitriol-9TsbxMN2fI
Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460100017006
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—I read with interest the article by Venkataraman et al1 in the October issue of AJDC. After reading their explanations and examining Fig 2, which did not indicate any dose-dependent calcium response to parenteral administration of 1,25-dihydroxyvitamin D, I wonder about the biological activity of the calcitriol that the authors used. I was also struck that the parathyroid hormone levels of the infants did not seem to respond at all to hypocalcemia, although markedly low calcium levels (such as 1.01 mmol/L [4.03 mg/dL]) were recorded. There was also no mention of the observation of tetany in these infants. These findings may suggest the inhibition of parathyroid hormone secretion in these infants, as is observed with administration of ethiofos (WR 2721),2 or acceptance of early neonatal hypocalcemia as a physiologic phenomenon that does not require treatment, as proposed by Scott et al.3 However, the determination of ionized References 1. Venkataraman PS, Tsang RC, Steichen JJ, et al: Early neonatal hypocalcemia in extremely preterm infants: High incidence, early onset, and refractoriness to supraphysiologic doses of calcitriol . AJDC 1986;140:1004-1008. 2. Glover D, Riley L, Carmichael K, et al: Hypocalcemia and inhibition of parathyroid hormone secretion after administration of WR-2721 (a radioprotective and chemoprotective agent) . N Engl J Med 1983;309:1137-1141.Crossref 3. Scott SM, Ladenson JH, Aguanna JJ, et al: Effect of calcium therapy in the sick premature infant with early neonatal hypocalcemia . J Pediatr 1984;104:747-751.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Oct 1, 1987

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month