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Biochemical Aspects of Otosclerosis

Biochemical Aspects of Otosclerosis Abstract IN SPITE OF the possibilities for symptomatic treatment by a variety of surgical interventions, otosclerosis has been and continues to be one of the unsolved problems in otology. Although innumerable attempts aimed at bringing light into the etiology of the disease were not successful, the formal genesis of otosclerosis as well as questions concerning developmental and structural features of the temporal bone and especially of the labyrinthine capsule have been cleared up to a large extent by morphologic studies. The bony labyrinth differs biologically and from an anatomicopathological point of view from all other bones of the skeleton. It is generally known that the osseous labyrinth like all other bones of the skull is preceded by a cartilaginous primordium. In the normal ossification process, all cartilage is replaced by compact and spongy bone, but in the endochondral layer of the labyrinthine capsule relatively large residues of hyaline cartilage persist throughout References 1. Guild, S.R.: Histologic Otosclerosis , Ann Otol 53:246, 1944. 2. Guild, S.R.: Symposium on Histology and Pathogenesis of Otosclerosis: Incidence, Location, and Extent of Otosclerotic Lesions , Arch Otolaryng 52:848, 1950.Crossref 3. Roche, J.; Filippi, A.; and Léandri, A.: Récheches sur l'ossification: III. La phosphatase des os longues aux diverses étapes de la croissance , Bull Soc Chim Biol 19:1314, 1937. 4. Sercer, A.: Die ontogenetische Entwicklung der Labyrinthkapsel , Arch Ohr Nas Kehlkopfheilk 173:357, 1958.Crossref 5. Maurer, H.: Vergleichende biochemische Knochenuntersuchungen bei der Otosklerose , Ann Univ Sarav (Med) 9:88, 1961-1962. 6. Fisher, R.A.: Statistical Methods for Research Workers , Edinburgh: Oliver & Boyd, 1925. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Biochemical Aspects of Otosclerosis

Archives of Otolaryngology , Volume 85 (3) – Mar 1, 1967

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1967.00760040240002
Publisher site
See Article on Publisher Site

Abstract

Abstract IN SPITE OF the possibilities for symptomatic treatment by a variety of surgical interventions, otosclerosis has been and continues to be one of the unsolved problems in otology. Although innumerable attempts aimed at bringing light into the etiology of the disease were not successful, the formal genesis of otosclerosis as well as questions concerning developmental and structural features of the temporal bone and especially of the labyrinthine capsule have been cleared up to a large extent by morphologic studies. The bony labyrinth differs biologically and from an anatomicopathological point of view from all other bones of the skeleton. It is generally known that the osseous labyrinth like all other bones of the skull is preceded by a cartilaginous primordium. In the normal ossification process, all cartilage is replaced by compact and spongy bone, but in the endochondral layer of the labyrinthine capsule relatively large residues of hyaline cartilage persist throughout References 1. Guild, S.R.: Histologic Otosclerosis , Ann Otol 53:246, 1944. 2. Guild, S.R.: Symposium on Histology and Pathogenesis of Otosclerosis: Incidence, Location, and Extent of Otosclerotic Lesions , Arch Otolaryng 52:848, 1950.Crossref 3. Roche, J.; Filippi, A.; and Léandri, A.: Récheches sur l'ossification: III. La phosphatase des os longues aux diverses étapes de la croissance , Bull Soc Chim Biol 19:1314, 1937. 4. Sercer, A.: Die ontogenetische Entwicklung der Labyrinthkapsel , Arch Ohr Nas Kehlkopfheilk 173:357, 1958.Crossref 5. Maurer, H.: Vergleichende biochemische Knochenuntersuchungen bei der Otosklerose , Ann Univ Sarav (Med) 9:88, 1961-1962. 6. Fisher, R.A.: Statistical Methods for Research Workers , Edinburgh: Oliver & Boyd, 1925.

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Mar 1, 1967

References