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Biochemical and Vascular Aspects of Pediatric Chronic Fatigue Syndrome

Biochemical and Vascular Aspects of Pediatric Chronic Fatigue Syndrome ARTICLE Biochemical and Vascular Aspects of Pediatric Chronic Fatigue Syndrome Gwen Kennedy, PhD; Faisel Khan, PhD; Alexander Hill, PhD; Christine Underwood, MBBS; Jill J. F. Belch, MD Objective: To evaluate the biochemical and vascular as- Results: Children with CFS/ME had increased oxidative pects of pediatric chronic fatigue syndrome/myalgic en- stress compared with control individuals (isoprostanes: cephalomyelitis (CFS/ME). 252.30 vs 215.60 pg/mL,P = .007; vitamin C, mean [SD]: 0.84 [0.26] vs 1.15 [0.28] mg/dL,P .001; vitamin E, 8.72 [2.39] vs 10.94 [3.46] µg/mL, P = .01) and increased white blood Design: Cross-sectional clinical study. cell apoptosis (neutrophils: 53.7% vs 35.7%, P = .005; lym- phocytes: 40.1% vs 24.6%, P = .009). Arterial stiffness vari- Setting: Tayside, Scotland, United Kingdom. ables did not differ significantly between groups (mean aug- mentation index, −0.57% vs −0.47%, P = .09); however, the Participants: Twenty-five children with CFS/ME and derived variables significantly correlated with total (r = 0.543, 23 healthy children recruited from throughout the United P = .02) and low-density lipoprotein (r = 0.631,P = .004) cho- Kingdom. lesterol in patients with CFS/ME but not in controls. Interventions: Participants underwent a full clinical ex- Conclusions: Biomedical anomalies seen in adults with amination to establish http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Biochemical and Vascular Aspects of Pediatric Chronic Fatigue Syndrome

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References (50)

Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/archpediatrics.2010.157
pmid
20819963
Publisher site
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Abstract

ARTICLE Biochemical and Vascular Aspects of Pediatric Chronic Fatigue Syndrome Gwen Kennedy, PhD; Faisel Khan, PhD; Alexander Hill, PhD; Christine Underwood, MBBS; Jill J. F. Belch, MD Objective: To evaluate the biochemical and vascular as- Results: Children with CFS/ME had increased oxidative pects of pediatric chronic fatigue syndrome/myalgic en- stress compared with control individuals (isoprostanes: cephalomyelitis (CFS/ME). 252.30 vs 215.60 pg/mL,P = .007; vitamin C, mean [SD]: 0.84 [0.26] vs 1.15 [0.28] mg/dL,P .001; vitamin E, 8.72 [2.39] vs 10.94 [3.46] µg/mL, P = .01) and increased white blood Design: Cross-sectional clinical study. cell apoptosis (neutrophils: 53.7% vs 35.7%, P = .005; lym- phocytes: 40.1% vs 24.6%, P = .009). Arterial stiffness vari- Setting: Tayside, Scotland, United Kingdom. ables did not differ significantly between groups (mean aug- mentation index, −0.57% vs −0.47%, P = .09); however, the Participants: Twenty-five children with CFS/ME and derived variables significantly correlated with total (r = 0.543, 23 healthy children recruited from throughout the United P = .02) and low-density lipoprotein (r = 0.631,P = .004) cho- Kingdom. lesterol in patients with CFS/ME but not in controls. Interventions: Participants underwent a full clinical ex- Conclusions: Biomedical anomalies seen in adults with amination to establish

Journal

JAMA Pediatrics – American Medical Association

Published: Sep 1, 2010

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