Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Binding of Corticosteroids by Plasma Proteins: V. Corticosteroid-Binding Globulin Activity in Normal Human Beings and in Certain Disease States

Binding of Corticosteroids by Plasma Proteins: V. Corticosteroid-Binding Globulin Activity in... Abstract The role of the blood plasma in the transport of nutrients, metabolic intermediates, and hormonal agents has long been recognized, yet there is now an increasing awareness of the degree to which plasma proteins may be specialized for this function. Uniquely adapted proteins are responsible for the transport of nearly all the neutral fat, cholesterol, and phospholipids of the plasma in colloidal solution.1 The free fatty acids of plasma, which have recently been shown to be of great importance in fat transport from the peripheral depots to the sites of oxidation, circulate nearly completely bound to the plasma albumin.2 Albumin also binds many other substances of physiologic significance. Most of the circulating iron of the plasma is bound to an iron-binding globulin.3 The degree of binding of thyroxine to a thyroxine-binding protein is well known and is made the basis of the familiar clinical index of thyroid References 1. Oncly, J. L.: Liproproteins of Human Plasma , Harvey Lect. 50:71, 1954-1955. 2. Teresi, J. D., and Luck, J. M.: The Combination of Organic Anions with Serum Albumin: VIII. Fatty Acid Salts , J. Biol. Chem. 194:823-834 ( (Feb.) ) 1952. 3. Rath, C. E., and Finch, C. A.: Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation: XXXVIII. Serum Iron Binding Capacity of Serum in Man , J. Clin. Invest. 28:78-85 ( (Jan.) ) 1949.Crossref 4. Larson, F.; Deiss, W. P., and Albright, E. C.: Localization of Protein-Bound Radioactive Iodine by Filter Paper Electrophoresis , Science 115:626-627 ( (June) ) 1952.Crossref 5. Laurell, C. B., and Nyman, M.: Studies on the Serum Haptoglobin Level in Hemoglobinemia and Its Influence on Renal Excretion of Hemoglobin , Blood 12:493-506 ( (June) ) 1957. 6. Pitney, W. R.; Beard, M. F., and Van Loon, E. J.: Observations on the Bound Form of Vitamin B12 in Human Serum , J. Biol. Chem. 207:143-152 ( (March) ) 1954. 7. Daughaday, W. H.: Binding of Corticosteroids by Plasma Proteins: I. Dialysis Equilibrium and Renal Clearance Studies , J. Clin. Invest. 35:1428-1433 ( (Dec.) ) 1956.Crossref 8. Eik-Nes, K.; Schellman, J. A.; Lumry, R., and Samuels, L. T.: The Binding of Steroids to Protein: I. Solubility Determinations , J. Biol. Chem. 206:414-419 ( (Jan.) ) 1954. 9. Westphal, U.: Steroid Protein Interpretations: III. Spectrophotometric Demonstrations of Interaction Between Proteins and Progesterone, Desoxycorticosterone and Cortisol , Arch. Biochem. 66:71-90 ( (Jan.) ) 1957.Crossref 10. Daughaday, W. H.: Binding of Corticosteroids by Plasma Proteins: III. Dialysis Equilibrium Measurements of the Binding of Hydrocortisone-4-C14, Corticosterone-4-C14 and Progestrone-4-C14 by Human Plasma , J. Clin. Invest. 37 (in press) 1958. 11. Daughaday, W. H.: Corticosteroid Binding by a Plasma Alpha Globulin , J. Clin. Invest. 36: 881 ( (June) ) 1957. 12. Dowling, J. T.; Freinkel, N., and Ingbar, S. H.: Thyroxine-Binding by Sera of Pregnant Women, Letters to the Editor , J. Clin. Endocrinol. 16:280-281 ( (Feb.) ) 1956.Crossref 13. Bayliss, R. I.; Browne, J. C.; Round, B. P., and Steinbeck, A. W.: Plasma 17-Hydroxycorticosteroids in Pregnancy , Lancet 1:62-67 ( (Tan.) ) 1955.Crossref 14. Venning, E. H., and Browne, J. S. L.: Urinary Excretion of Adrenal Cortical Steroids , Ann. New York Acad. Sc. 50:430-434 ( (Oct.) ) 1949. 15. Elman, R.; Weichselbaum, T. E.; Moncrief, J. C., and Margraf, H. W.: Adrenal Cortical Steroids Following Elective Operations: Quantitative Studies in the Peripheral Plasma of 17-Hydroxy- and 17 Desoxycorticosteroids , A. M. A. Arch. Surg. 71:697-705 ( (Nov.) ) 1955.Crossref 16. Robbins, J., and Rall, J. E.: Physiological Implications of Thyroxine-Binding by Serum Proteins , J. Clin. Invest. 36:923 ( (June) ) 1957.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

Binding of Corticosteroids by Plasma Proteins: V. Corticosteroid-Binding Globulin Activity in Normal Human Beings and in Certain Disease States

Loading next page...
 
/lp/american-medical-association/binding-of-corticosteroids-by-plasma-proteins-v-corticosteroid-binding-x9TX0QA8oS
Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1958.00260140118017
Publisher site
See Article on Publisher Site

Abstract

Abstract The role of the blood plasma in the transport of nutrients, metabolic intermediates, and hormonal agents has long been recognized, yet there is now an increasing awareness of the degree to which plasma proteins may be specialized for this function. Uniquely adapted proteins are responsible for the transport of nearly all the neutral fat, cholesterol, and phospholipids of the plasma in colloidal solution.1 The free fatty acids of plasma, which have recently been shown to be of great importance in fat transport from the peripheral depots to the sites of oxidation, circulate nearly completely bound to the plasma albumin.2 Albumin also binds many other substances of physiologic significance. Most of the circulating iron of the plasma is bound to an iron-binding globulin.3 The degree of binding of thyroxine to a thyroxine-binding protein is well known and is made the basis of the familiar clinical index of thyroid References 1. Oncly, J. L.: Liproproteins of Human Plasma , Harvey Lect. 50:71, 1954-1955. 2. Teresi, J. D., and Luck, J. M.: The Combination of Organic Anions with Serum Albumin: VIII. Fatty Acid Salts , J. Biol. Chem. 194:823-834 ( (Feb.) ) 1952. 3. Rath, C. E., and Finch, C. A.: Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation: XXXVIII. Serum Iron Binding Capacity of Serum in Man , J. Clin. Invest. 28:78-85 ( (Jan.) ) 1949.Crossref 4. Larson, F.; Deiss, W. P., and Albright, E. C.: Localization of Protein-Bound Radioactive Iodine by Filter Paper Electrophoresis , Science 115:626-627 ( (June) ) 1952.Crossref 5. Laurell, C. B., and Nyman, M.: Studies on the Serum Haptoglobin Level in Hemoglobinemia and Its Influence on Renal Excretion of Hemoglobin , Blood 12:493-506 ( (June) ) 1957. 6. Pitney, W. R.; Beard, M. F., and Van Loon, E. J.: Observations on the Bound Form of Vitamin B12 in Human Serum , J. Biol. Chem. 207:143-152 ( (March) ) 1954. 7. Daughaday, W. H.: Binding of Corticosteroids by Plasma Proteins: I. Dialysis Equilibrium and Renal Clearance Studies , J. Clin. Invest. 35:1428-1433 ( (Dec.) ) 1956.Crossref 8. Eik-Nes, K.; Schellman, J. A.; Lumry, R., and Samuels, L. T.: The Binding of Steroids to Protein: I. Solubility Determinations , J. Biol. Chem. 206:414-419 ( (Jan.) ) 1954. 9. Westphal, U.: Steroid Protein Interpretations: III. Spectrophotometric Demonstrations of Interaction Between Proteins and Progesterone, Desoxycorticosterone and Cortisol , Arch. Biochem. 66:71-90 ( (Jan.) ) 1957.Crossref 10. Daughaday, W. H.: Binding of Corticosteroids by Plasma Proteins: III. Dialysis Equilibrium Measurements of the Binding of Hydrocortisone-4-C14, Corticosterone-4-C14 and Progestrone-4-C14 by Human Plasma , J. Clin. Invest. 37 (in press) 1958. 11. Daughaday, W. H.: Corticosteroid Binding by a Plasma Alpha Globulin , J. Clin. Invest. 36: 881 ( (June) ) 1957. 12. Dowling, J. T.; Freinkel, N., and Ingbar, S. H.: Thyroxine-Binding by Sera of Pregnant Women, Letters to the Editor , J. Clin. Endocrinol. 16:280-281 ( (Feb.) ) 1956.Crossref 13. Bayliss, R. I.; Browne, J. C.; Round, B. P., and Steinbeck, A. W.: Plasma 17-Hydroxycorticosteroids in Pregnancy , Lancet 1:62-67 ( (Tan.) ) 1955.Crossref 14. Venning, E. H., and Browne, J. S. L.: Urinary Excretion of Adrenal Cortical Steroids , Ann. New York Acad. Sc. 50:430-434 ( (Oct.) ) 1949. 15. Elman, R.; Weichselbaum, T. E.; Moncrief, J. C., and Margraf, H. W.: Adrenal Cortical Steroids Following Elective Operations: Quantitative Studies in the Peripheral Plasma of 17-Hydroxy- and 17 Desoxycorticosteroids , A. M. A. Arch. Surg. 71:697-705 ( (Nov.) ) 1955.Crossref 16. Robbins, J., and Rall, J. E.: Physiological Implications of Thyroxine-Binding by Serum Proteins , J. Clin. Invest. 36:923 ( (June) ) 1957.Crossref

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1958

References