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BILIARY AND HEPATIC FACTORS IN PEPTIC ULCERS: AN EXPERIMENTAL STUDY

BILIARY AND HEPATIC FACTORS IN PEPTIC ULCERS: AN EXPERIMENTAL STUDY Abstract Numerous investigators1 observed the occurrence of peptic ulcers in animals following the diversion of duodenal secretions, and attributed the development of these lesions to the loss of the neutralizing influence of the alkaline duodenal fluids on the acid gastric juice. Their conclusions were based on the work of Boldyreff,2 who promulgated the theory that gastric acidity was regulated by the regurgitation of the contents of the duodenum into the stomach. Boldyreff noted that the pancreatic juice was more alkaline than any of the other secretions that were present in the duodenum, and he believed that it was the chief factor in the neutralization of the acid secreted by the stomach. The results of the investigations of MacLean and Griffiths,3 McCann,4 and Yesko,5 however, indicated that changes in gastric acidity did not depend on the regurgitation of alkaline duodenal juices. Recent determinations6 of the gastric References 1. Hauser, G.: Die peptischen schädigungen des Magens, des Duodenums und der Speiseröhre und das peptische postoperative Jejunalgeschwür , in Henke and Lubarsch: Handbuch der speziellen pathologischen Anatomie und Histologie , Berlin, Julius Springer, 1926, vol. 4. 2. Bickel, A.: Beobachtungen an Hunden mit exstirpierten Duodenum , Berl. klin. Wchnschr. 46:1201 ( (June 28) ) 1909. 3. Exalto, J.: Ulcus jejuni nach Gastroenterostomie , München. med. Wchnschr. 58:1144 ( (May 23) ) 1911. 4. Mann, F. C., and Williamson, C. S.: The Experimental Production of Peptic Ulcer , Ann. Surg. 77:420 ( (April) ) 1923.Crossref 5. Boldyreff, W.: Self Regulation of Acidity of Gastric Contents and Real Acidity of the Gastric Juice , Quart. J. Exper. Physiol. 8:1 ( (April 14) ) 1914. 6. MacLean, H., and Griffiths, W. J.: The Automatic Regulation of Gastric Acidity , J. Physiol. 66:356 ( (Dec. 20) ) 1928. 7. McCann, J. C.: Studies on the Control of the Acidity of the Gastric Juice , Am. J. Physiol. 89:483 ( (Aug.) ) 1929. 8. Yesko, S. A.: The Effects of Ligation of Pancreatic Ducts on Gastric Digestion , Am. J. Physiol. 86:483 ( (Oct.) ) 1928. 9. Unpublished observations. 10. Still, K. S., and Carlson, A. J.: The Motor and Secretory Activity of the Stomach During Acute and Chronic Obstructive Jaundice in Dogs , Am. J. Physiol. 89:34 ( (June) ) 1929. 11. Minkowski, O.: Untersuchungen über den Diabetes Mellitus nach Extirpation des Pankreas , Arch. f. exper. Path. u. Pharmakol. 31:85 ( (April 11) ) 1893.Crossref 12. Malkoff, G. M.: The Pathology of Jaundice , St. Petersburg, Imperial Military Medical Academy, 1897. 13. Bogoras, N.: Ueber Cholecystogastrostomie bei dem Magenulcus , Arch. f. klin. Chir. 134:42 ( (Jan. 26) ) 1925. 14. Hosomi, K.: Ueber das sogenannte peptische geschwür des Magens und Duodenums beim Hunde, das gelegentlich der Choledochusplastik entsteht , Virchows Arch. f. path. Anat. 267:726 ( (March 21) ) 1928.Crossref 15. Kapsinow, R.: Experimental Production of Duodenal Ulcer by Exclusion of Bile from the Intestine , Ann. Surg. 83:614 ( (May) ) 1926.Crossref 16. Bollman, J. L., and Mann, F. C.: Chronic Duodenal Ulcers in Animals with Eck Fistulas on Certain Diets , Arch. Path. 4:492 ( (Sept.) ) 1927. 17. Rous, P., and McMaster, P. D.: A Method for the Permanent Sterile Drainage of Intra-Abdominal Ducts as Applied to the Common Duct , J. Exper. Med. 37:11 ( (Jan.) ) 1923.Crossref 18. Mann and Williamson (footnote 1, fourth reference). 19. Beaumont, W.: Experiments and Observations on the Gastric Juice and the Physiology of Digestion , Plattsburgh, F. P. Allen, 1833, p. 103. 20. Bernard, Claude: Physiologie expérimentale , Paris, J. B. Baillière et fils, 1856, vol. 2, p. 408. 21. Pavlov, I.: The Work of the Digestive Glands , London, Griffin & Company, 1910, p. 238. 22. Bensley, R. R.: The Structure of the Glands of Brunner , Decennial Publications, University of Chicago, 1903, vol. 10, p. 279. 23. Bensley, R. R.: The Structure of the Mammalian Gastric Glands , Quart. J. Micr. Sc. 41:361 ( (Nov.) ) 1898. 24. Lim, R. K. S.: The Gastric Mucosa , Quart. J. Micr. Sc. 66:187 ( (June) ) 1922. 25. Schmidt, A.: Ueber die Schleimabsonderung im Magen , Deutsches Arch. f. klin. Med. 57:65 ( (May 28) ) 1896. 26. Kaufmann, J.: Mangel an Magenschleim (Amyxorrhoea gastrica) seine pathologische Bedeutung und seine Beziehungen zur Hyperacidität und zum Magenschwür , Arch. f. Verdauungskr. 13:616 ( (Dec. 20) ) 1907.Crossref 27. Foster, N. B.: The Chemical Affinity of Mucus for Hydrochloric Acid , Am. J. M. Sc. 133:303 ( (Feb.) ) 1907.Crossref 28. Sherwood, W. A.: Surgical Lesions of the Biliary Tract , Ann. Surg. 88:178 ( (Aug.) ) 1928.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

BILIARY AND HEPATIC FACTORS IN PEPTIC ULCERS: AN EXPERIMENTAL STUDY

Archives of Surgery , Volume 20 (6) – Jun 1, 1930

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Publisher
American Medical Association
Copyright
Copyright © 1930 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1930.01150120115006
Publisher site
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Abstract

Abstract Numerous investigators1 observed the occurrence of peptic ulcers in animals following the diversion of duodenal secretions, and attributed the development of these lesions to the loss of the neutralizing influence of the alkaline duodenal fluids on the acid gastric juice. Their conclusions were based on the work of Boldyreff,2 who promulgated the theory that gastric acidity was regulated by the regurgitation of the contents of the duodenum into the stomach. Boldyreff noted that the pancreatic juice was more alkaline than any of the other secretions that were present in the duodenum, and he believed that it was the chief factor in the neutralization of the acid secreted by the stomach. The results of the investigations of MacLean and Griffiths,3 McCann,4 and Yesko,5 however, indicated that changes in gastric acidity did not depend on the regurgitation of alkaline duodenal juices. Recent determinations6 of the gastric References 1. Hauser, G.: Die peptischen schädigungen des Magens, des Duodenums und der Speiseröhre und das peptische postoperative Jejunalgeschwür , in Henke and Lubarsch: Handbuch der speziellen pathologischen Anatomie und Histologie , Berlin, Julius Springer, 1926, vol. 4. 2. Bickel, A.: Beobachtungen an Hunden mit exstirpierten Duodenum , Berl. klin. Wchnschr. 46:1201 ( (June 28) ) 1909. 3. Exalto, J.: Ulcus jejuni nach Gastroenterostomie , München. med. Wchnschr. 58:1144 ( (May 23) ) 1911. 4. Mann, F. C., and Williamson, C. S.: The Experimental Production of Peptic Ulcer , Ann. Surg. 77:420 ( (April) ) 1923.Crossref 5. Boldyreff, W.: Self Regulation of Acidity of Gastric Contents and Real Acidity of the Gastric Juice , Quart. J. Exper. Physiol. 8:1 ( (April 14) ) 1914. 6. MacLean, H., and Griffiths, W. J.: The Automatic Regulation of Gastric Acidity , J. Physiol. 66:356 ( (Dec. 20) ) 1928. 7. McCann, J. C.: Studies on the Control of the Acidity of the Gastric Juice , Am. J. Physiol. 89:483 ( (Aug.) ) 1929. 8. Yesko, S. A.: The Effects of Ligation of Pancreatic Ducts on Gastric Digestion , Am. J. Physiol. 86:483 ( (Oct.) ) 1928. 9. Unpublished observations. 10. Still, K. S., and Carlson, A. J.: The Motor and Secretory Activity of the Stomach During Acute and Chronic Obstructive Jaundice in Dogs , Am. J. Physiol. 89:34 ( (June) ) 1929. 11. Minkowski, O.: Untersuchungen über den Diabetes Mellitus nach Extirpation des Pankreas , Arch. f. exper. Path. u. Pharmakol. 31:85 ( (April 11) ) 1893.Crossref 12. Malkoff, G. M.: The Pathology of Jaundice , St. Petersburg, Imperial Military Medical Academy, 1897. 13. Bogoras, N.: Ueber Cholecystogastrostomie bei dem Magenulcus , Arch. f. klin. Chir. 134:42 ( (Jan. 26) ) 1925. 14. Hosomi, K.: Ueber das sogenannte peptische geschwür des Magens und Duodenums beim Hunde, das gelegentlich der Choledochusplastik entsteht , Virchows Arch. f. path. Anat. 267:726 ( (March 21) ) 1928.Crossref 15. Kapsinow, R.: Experimental Production of Duodenal Ulcer by Exclusion of Bile from the Intestine , Ann. Surg. 83:614 ( (May) ) 1926.Crossref 16. Bollman, J. L., and Mann, F. C.: Chronic Duodenal Ulcers in Animals with Eck Fistulas on Certain Diets , Arch. Path. 4:492 ( (Sept.) ) 1927. 17. Rous, P., and McMaster, P. D.: A Method for the Permanent Sterile Drainage of Intra-Abdominal Ducts as Applied to the Common Duct , J. Exper. Med. 37:11 ( (Jan.) ) 1923.Crossref 18. Mann and Williamson (footnote 1, fourth reference). 19. Beaumont, W.: Experiments and Observations on the Gastric Juice and the Physiology of Digestion , Plattsburgh, F. P. Allen, 1833, p. 103. 20. Bernard, Claude: Physiologie expérimentale , Paris, J. B. Baillière et fils, 1856, vol. 2, p. 408. 21. Pavlov, I.: The Work of the Digestive Glands , London, Griffin & Company, 1910, p. 238. 22. Bensley, R. R.: The Structure of the Glands of Brunner , Decennial Publications, University of Chicago, 1903, vol. 10, p. 279. 23. Bensley, R. R.: The Structure of the Mammalian Gastric Glands , Quart. J. Micr. Sc. 41:361 ( (Nov.) ) 1898. 24. Lim, R. K. S.: The Gastric Mucosa , Quart. J. Micr. Sc. 66:187 ( (June) ) 1922. 25. Schmidt, A.: Ueber die Schleimabsonderung im Magen , Deutsches Arch. f. klin. Med. 57:65 ( (May 28) ) 1896. 26. Kaufmann, J.: Mangel an Magenschleim (Amyxorrhoea gastrica) seine pathologische Bedeutung und seine Beziehungen zur Hyperacidität und zum Magenschwür , Arch. f. Verdauungskr. 13:616 ( (Dec. 20) ) 1907.Crossref 27. Foster, N. B.: The Chemical Affinity of Mucus for Hydrochloric Acid , Am. J. M. Sc. 133:303 ( (Feb.) ) 1907.Crossref 28. Sherwood, W. A.: Surgical Lesions of the Biliary Tract , Ann. Surg. 88:178 ( (Aug.) ) 1928.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Jun 1, 1930

References

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