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Bilateral Salpingo-Oophorectomy to Reduce Breast Cancer Risk in Women With Germline BRCA1 or BRCA2 Pathogenic Variants—Caution Needed

Bilateral Salpingo-Oophorectomy to Reduce Breast Cancer Risk in Women With Germline BRCA1 or... Letters Conflict of Interest Disclosures: Dr Mao reported receiving grants from the Finally, there appears to be a possible error in Table 1, Department of Defense Congressionally Directed Medical Research whereby the total number of women undergoing RRSO is less Programs through the Peer Reviewed Medical Research Program Clinical Trial than the sum of the corresponding numbers broken down by Award (W81XWH-15-1-0245) and a National Institutes of Health/National Cancer age groups younger than 50 years. Institute Cancer Center grant (P30 CA008748) related to the submitted 2-5 work and grants from Tibet Cheezheng Tibetan Medicine Co, Ltd, and Zhongke Other contemporary studies addressing this question do Health International, LLC, outside the submitted work. No other disclosures not provide consistent evidence to support the use of RRSO were reported. for the prevention of breast cancer in BRCA1 and BRCA2 vari- Disclaimer: Opinions, interpretations, conclusions, and recommendations in ant carriers. Considering the potential biases and confound- this article are those of the authors and are not necessarily endorsed by the ing in the existing observational studies, including Choi et al, Department of Defense. we urge caution around offering early premenopausal RRSO 1. Mao JJ, Liou KT, Baser RE, et al. Effectiveness of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Oncology American Medical Association

Bilateral Salpingo-Oophorectomy to Reduce Breast Cancer Risk in Women With Germline BRCA1 or BRCA2 Pathogenic Variants—Caution Needed

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
2374-2437
eISSN
2374-2445
DOI
10.1001/jamaoncol.2021.2037
Publisher site
See Article on Publisher Site

Abstract

Letters Conflict of Interest Disclosures: Dr Mao reported receiving grants from the Finally, there appears to be a possible error in Table 1, Department of Defense Congressionally Directed Medical Research whereby the total number of women undergoing RRSO is less Programs through the Peer Reviewed Medical Research Program Clinical Trial than the sum of the corresponding numbers broken down by Award (W81XWH-15-1-0245) and a National Institutes of Health/National Cancer age groups younger than 50 years. Institute Cancer Center grant (P30 CA008748) related to the submitted 2-5 work and grants from Tibet Cheezheng Tibetan Medicine Co, Ltd, and Zhongke Other contemporary studies addressing this question do Health International, LLC, outside the submitted work. No other disclosures not provide consistent evidence to support the use of RRSO were reported. for the prevention of breast cancer in BRCA1 and BRCA2 vari- Disclaimer: Opinions, interpretations, conclusions, and recommendations in ant carriers. Considering the potential biases and confound- this article are those of the authors and are not necessarily endorsed by the ing in the existing observational studies, including Choi et al, Department of Defense. we urge caution around offering early premenopausal RRSO 1. Mao JJ, Liou KT, Baser RE, et al. Effectiveness of

Journal

JAMA OncologyAmerican Medical Association

Published: Sep 1, 2021

References