Abstract • Five young men had painless, progressive, bilateral loss of central vision with late optic atrophy. One had a family history of Leber's optic neuropathy. After being functionally blind for four to 21 months, spontaneous improvement began leading to remarkable recovery of vision in all patients. We propose that these are cases of Leber's optic neuropathy in which an unusual capacity for recovery may have been related to a lack of microvascular abnormalities in the fundi. References 1. Perkin GD, Rose FC: Optic Neuritis and its Differential Diagnosis . Oxford, England, Oxford University Press, 1979. 2. Lynn BH: Retrobulbar neuritis: A survey of the present condition of cases occurring over the last 56 years . Trans Ophthalmol Soc UK 1959;79:701-716. 3. Nikoskelainen E: Symptoms, signs and early course of optic neuritis . Acta Ophthalmol 1975;53:254-272.Crossref 4. Hierons R, Lyle TK: Bilateral retrobulbar optic neuritis . Brain 1959;82:56-67.Crossref 5. Vans Senus AHC: Leber's disease in the Netherlands . Doc Ophthalmol 1963;17:1-162.Crossref 6. Duke-Elder S, Scott GI: System of Ophthalmology . St Louis, CV Mosby Co, 1971, vol 12, p 108. 7. Lundsgaard R: Leber's disease: A genealogic, genetic, and clinical study of 101 cases of retrobulbar optic neuritis in 20 Danish families . Acta Ophthalmol , 1944, (suppl 21) , pp 1-306. 8. Constantine EF: Leber's disease with recovery . Arch Ophthalmol 1955;53:608. 9. Brunette JR, Bernier G: Study of a family of Leber's optic atrophy with recuperation , in Brunette JR, Barbeau A (eds): Progress in Neuro-Ophthalmology . Amsterdam, Excerpta Medica, 1969, pp 91-97. 10. Stendahl-Brodin L, Moller E, Link H: Hereditary optic atrophy with probable association with a specific HLA haplotype . J Neurol Sci 1978;38:11-21.Crossref 11. Smith JL, Hoyt WF, Susac JO: Ocular fundus in acute Leber optic neuropathy . Arch Ophthalmol 1973;90:349-354.Crossref 12. Nikoskelainen E, Sogg RL, Rosenthal AR, et al: The early phase in Leber hereditary optic atrophy . Arch Ophthalmol 1977;95:969-978.Crossref 13. Carroll WM, Mastaglia FL: Leber's optic neuropathy: A clinical and evoked potential study of affected and asymptomatic members of a six generation family . Brain 1979;102:559-580.Crossref 14. Trobe JD, Glaser JS, Cassady JC: Optic atrophy differential diagnosis by fundus observation alone . Arch Ophthalmol 1980;98:1040-1045.Crossref 15. Rogers JA: Leber's disease . Aust J Ophthalmol 1977;5:111-119.Crossref
Archives of Neurology – American Medical Association
Published: Jan 1, 1983
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