CLINICAL NOTE Bilateral Obstructing Laryngeal Epithelial Adenomatous Hamartomas Robert A. Buckmire, MD; Tack-Kyun Kwon, MD n 1991, the World Health Organization defined hamartomas as anomalies characterized by the formation of a tumorlike mass composed of identical mature cellular tissue elements that are normally present where the mass is found but that occur in abnormal proportions I or patterns. A hamartoma does not have the capability of continuous growth or recur- rence and is composed of a single germ layer, distinguishing it from a true neoplasm and a tera- toma, respectively. It is also distinct from a choristoma because it is composed of tissue elements that are normally found in the region. Finally, because this type of focal overgrowth does not pro- duce the normal architecture of the surrounding tissues, hamartomas should be further differen- tiated from hyperplasia. Hamartomas, which are most commonly REPORT OF A CASE found in the lungs, kidneys, and intes- tine, rarely occur in the upper respira- A 35-year-old woman presented to the tory tract. In 1998, Rinaldo et al re- voice clinic with a more than 6-year his- viewed 11 cases of laryngeal hamartoma, tory of hoarseness associated with the long- and since then, only
JAMA Otolaryngology - Head & Neck Surgery – American Medical Association
Published: Mar 1, 2005
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