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Bilateral Corneal Immune Ring Opacity in Behcet's Syndrome

Bilateral Corneal Immune Ring Opacity in Behcet's Syndrome Abstract Ring-shaped infiltration of the corneal stroma, known as Wessely ring, is believed to result from intrastromal interaction of antigens, from either an infecting organism or altered corneal tissue, with antibodies diffusing into the cornea from the limbus.1 These complexes activate, complement, and subsequently attract inflammatory cells. We report a rare case of Behcet's disease in which both antibodies and antigens probably originated from the limbal vasculature. They diffused either separately or as an immune complex and precipitated in the stromal midperiphery, where an optimal concentration was achieved. Report of a Case. —A 16-year-old girl known to have Behcet's syndrome for 7 years was referred to our department. Her ophthalmic history consisted of recurrent nonpurulent conjunctivitis. Her visual acuity was 20/20 and the intraocular pressure was normal bilaterally. In the inferotemporal corneal periphery a semilunar stromal opacity was noted 1.5 mm from the limbus continuous with a stromal immune ring References 1. Robin JB, Schanzlin DJ, Verity SM, et al. Peripheral corneal disorders . Surv Ophthalmol . 1986;31:1-36.Crossref 2. Reed CE, Friedlander M. Immunologic aspects of diseases of the eye . JAMA . 1982;248:2692-2695.Crossref 3. Duke-Elder S. Diseases of the outer eye . In: System of Ophthalmology . London, England: Henry Kimpton; 1965;8:532-534. 4. Sen DK. Endogenous uveitis in Indian children: analysis of 94 cases . J Pediatr Ophthalmol . 1977;14:25-32. 5. Gupta RC, O'Duffy JD, McDuffie FC, Meurer M, Jordon RE. Circulating immune complexes in active Behcet's disease . Clin Exp Immunol . 1978;34:213-218. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Bilateral Corneal Immune Ring Opacity in Behcet's Syndrome

Archives of Ophthalmology , Volume 109 (3) – Mar 1, 1991

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Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1991.01080030026023
Publisher site
See Article on Publisher Site

Abstract

Abstract Ring-shaped infiltration of the corneal stroma, known as Wessely ring, is believed to result from intrastromal interaction of antigens, from either an infecting organism or altered corneal tissue, with antibodies diffusing into the cornea from the limbus.1 These complexes activate, complement, and subsequently attract inflammatory cells. We report a rare case of Behcet's disease in which both antibodies and antigens probably originated from the limbal vasculature. They diffused either separately or as an immune complex and precipitated in the stromal midperiphery, where an optimal concentration was achieved. Report of a Case. —A 16-year-old girl known to have Behcet's syndrome for 7 years was referred to our department. Her ophthalmic history consisted of recurrent nonpurulent conjunctivitis. Her visual acuity was 20/20 and the intraocular pressure was normal bilaterally. In the inferotemporal corneal periphery a semilunar stromal opacity was noted 1.5 mm from the limbus continuous with a stromal immune ring References 1. Robin JB, Schanzlin DJ, Verity SM, et al. Peripheral corneal disorders . Surv Ophthalmol . 1986;31:1-36.Crossref 2. Reed CE, Friedlander M. Immunologic aspects of diseases of the eye . JAMA . 1982;248:2692-2695.Crossref 3. Duke-Elder S. Diseases of the outer eye . In: System of Ophthalmology . London, England: Henry Kimpton; 1965;8:532-534. 4. Sen DK. Endogenous uveitis in Indian children: analysis of 94 cases . J Pediatr Ophthalmol . 1977;14:25-32. 5. Gupta RC, O'Duffy JD, McDuffie FC, Meurer M, Jordon RE. Circulating immune complexes in active Behcet's disease . Clin Exp Immunol . 1978;34:213-218.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1991

References

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