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Better Outcomes for Patients Treated at Hospitals That Participate in Clinical Trials

Better Outcomes for Patients Treated at Hospitals That Participate in Clinical Trials ORIGINAL INVESTIGATION Better Outcomes for Patients Treated at Hospitals That Participate in Clinical Trials Sumit R. Majumdar, MD, MPH; Matthew T. Roe, MD, MHS; Eric D. Peterson, MD, MPH; Anita Y. Chen, MS; W. Brian Gibler, MD; Paul W. Armstrong, MD Background: Barriers to institutions participating in increased with increasing tertiles of trial participation: clinical trials include concerns about harms and costs. 76.9% (IQR, 71.8%-81.3%) vs 78.3% (IQR, 73.2%- However, we hypothesized that patients treated at hos- 82.4%) vs 81.1% (IQR, 76.2%-84.1%) (adjusted P = .008). pitals participating in trials would have better outcomes Hospitals that participated in trials had higher adjusted than patients treated at nonparticipating hospitals. We guideline adherence than nonparticipating hospitals (low tested this hypothesis in 494 CRUSADE (Can Rapid Risk enrollment, 0.8% greater [95% confidence interval {CI}, Stratification of Unstable Angina Patients Suppress Ad- −0.9% to 2.6%]; and high enrollment, 2.5% greater [95% verse Outcomes With Early Implementation of the Ameri- CI, 0.5%-4.5%]). In-hospital mortality decreased with in- can College of Cardiology/American Heart Association creasing trial participation: 5.9% vs 4.4% vs 3.5% (ad- Guidelines) hospitals treating 174 062 patients with non– justed P = .003). Patients treated at hospitals that partici- ST-segment elevation acute coronary http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Better Outcomes for Patients Treated at Hospitals That Participate in Clinical Trials

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References (18)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinternmed.2007.124
pmid
18362259
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL INVESTIGATION Better Outcomes for Patients Treated at Hospitals That Participate in Clinical Trials Sumit R. Majumdar, MD, MPH; Matthew T. Roe, MD, MHS; Eric D. Peterson, MD, MPH; Anita Y. Chen, MS; W. Brian Gibler, MD; Paul W. Armstrong, MD Background: Barriers to institutions participating in increased with increasing tertiles of trial participation: clinical trials include concerns about harms and costs. 76.9% (IQR, 71.8%-81.3%) vs 78.3% (IQR, 73.2%- However, we hypothesized that patients treated at hos- 82.4%) vs 81.1% (IQR, 76.2%-84.1%) (adjusted P = .008). pitals participating in trials would have better outcomes Hospitals that participated in trials had higher adjusted than patients treated at nonparticipating hospitals. We guideline adherence than nonparticipating hospitals (low tested this hypothesis in 494 CRUSADE (Can Rapid Risk enrollment, 0.8% greater [95% confidence interval {CI}, Stratification of Unstable Angina Patients Suppress Ad- −0.9% to 2.6%]; and high enrollment, 2.5% greater [95% verse Outcomes With Early Implementation of the Ameri- CI, 0.5%-4.5%]). In-hospital mortality decreased with in- can College of Cardiology/American Heart Association creasing trial participation: 5.9% vs 4.4% vs 3.5% (ad- Guidelines) hospitals treating 174 062 patients with non– justed P = .003). Patients treated at hospitals that partici- ST-segment elevation acute coronary

Journal

JAMA Internal MedicineAmerican Medical Association

Published: Mar 24, 2008

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