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Bethanechol or Cimetidine in the Treatment of Symptomatic Reflux Esophagitis: A Double-blind Control Study

Bethanechol or Cimetidine in the Treatment of Symptomatic Reflux Esophagitis: A Double-blind... Abstract • We conducted a double-blind study to compare the effectiveness of oral bethanechol chloride or cimetidine in treating reflux esophagitis to evaluate the drugs' effects on the symptoms of esophagitis and its verification by endoscopy. Forty-three patients were treated with either 300 mg of cimetidine or 25 mg of bethanechol chloride, each administered four times a day for six weeks. In addition to this drug treatment, the patients all received conventional medical therapy. Patients who were treated with either of the two drugs experienced a decrease in symptoms and less severe endoscopic lesions. While cimetidine treatment resulted in complete endoscopic healing in 15 of 22 patients, bethanechol treatment resulted in the same healing in 11 of 21 patients. During therapy, neither endoscopic lesions or symptoms worsened. Our study indicated that either cimetidine or bethanechol is an effective drug in treating reflux esophagitis. The effects of the two drugs can be favorably compared. (Arch Intern Med 1982;142:1479-1481) References 1. Farrell RL, Roling GT, Castell DO: Stimulation of the incompetent lower esophageal sphincter. Am J Dig Dis 1973;18:646-650.Crossref 2. Thanik KD, Chey WY, Shah AN, et al: Reflux esophagitis: Effect of oral bethanechol on symptoms and endoscopic findings. Ann Intern Med 1980;93:805-808.Crossref 3. Behar J, Biancani P: Effect of oral metoclopramide on gastro-esophageal reflux in the post-cibal state. Gastroenterology 1976;70:331-335. 4. McCallum RW, Ippoliti AF, Cooney C, et al: A controlled trial of metoclopramide in symptomatic gastro-esophageal reflux. N Engl J Med 1977;296:354-357.Crossref 5. McCluskie RA, Bardhan KD, Saul DM, et al: Cimetidine in the treatment of esophagitis , in Burland WL, Simkius MA (eds): Cimetidine: Proceedings of the Second International Symposium on Histamine. H2-Receptor Antagonists . Amsterdam, Excerpta Medica, 1977, pp 297-304. 6. Behar J, Brand DL, Brown FC, et al: Cimetidine in the treatment of symptomatic gastroesophageal reflux: A double-blind controlled trial. Gastroenterology 1978;74:441-448. 7. Wesdorp E, Bartelswau J, Pape K, et al: Oral cimetidine in reflux esophagitis: A double-blind controlled trial. Gastroenterology 1978;74:821-824. 8. Powell-Jackson P, Barkley H, Northfield TC: Effect of cimetidine in symptomatic gastro-esophageal reflux. Lancet 1978;2:1068-1069.Crossref 9. Fiasse R, Hamin C, Lepot A, et al: Controlled trial of cimetidine in reflux esophagitis. Dig Dis Sci 1980;25:750-755.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Bethanechol or Cimetidine in the Treatment of Symptomatic Reflux Esophagitis: A Double-blind Control Study

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340210073016
Publisher site
See Article on Publisher Site

Abstract

Abstract • We conducted a double-blind study to compare the effectiveness of oral bethanechol chloride or cimetidine in treating reflux esophagitis to evaluate the drugs' effects on the symptoms of esophagitis and its verification by endoscopy. Forty-three patients were treated with either 300 mg of cimetidine or 25 mg of bethanechol chloride, each administered four times a day for six weeks. In addition to this drug treatment, the patients all received conventional medical therapy. Patients who were treated with either of the two drugs experienced a decrease in symptoms and less severe endoscopic lesions. While cimetidine treatment resulted in complete endoscopic healing in 15 of 22 patients, bethanechol treatment resulted in the same healing in 11 of 21 patients. During therapy, neither endoscopic lesions or symptoms worsened. Our study indicated that either cimetidine or bethanechol is an effective drug in treating reflux esophagitis. The effects of the two drugs can be favorably compared. (Arch Intern Med 1982;142:1479-1481) References 1. Farrell RL, Roling GT, Castell DO: Stimulation of the incompetent lower esophageal sphincter. Am J Dig Dis 1973;18:646-650.Crossref 2. Thanik KD, Chey WY, Shah AN, et al: Reflux esophagitis: Effect of oral bethanechol on symptoms and endoscopic findings. Ann Intern Med 1980;93:805-808.Crossref 3. Behar J, Biancani P: Effect of oral metoclopramide on gastro-esophageal reflux in the post-cibal state. Gastroenterology 1976;70:331-335. 4. McCallum RW, Ippoliti AF, Cooney C, et al: A controlled trial of metoclopramide in symptomatic gastro-esophageal reflux. N Engl J Med 1977;296:354-357.Crossref 5. McCluskie RA, Bardhan KD, Saul DM, et al: Cimetidine in the treatment of esophagitis , in Burland WL, Simkius MA (eds): Cimetidine: Proceedings of the Second International Symposium on Histamine. H2-Receptor Antagonists . Amsterdam, Excerpta Medica, 1977, pp 297-304. 6. Behar J, Brand DL, Brown FC, et al: Cimetidine in the treatment of symptomatic gastroesophageal reflux: A double-blind controlled trial. Gastroenterology 1978;74:441-448. 7. Wesdorp E, Bartelswau J, Pape K, et al: Oral cimetidine in reflux esophagitis: A double-blind controlled trial. Gastroenterology 1978;74:821-824. 8. Powell-Jackson P, Barkley H, Northfield TC: Effect of cimetidine in symptomatic gastro-esophageal reflux. Lancet 1978;2:1068-1069.Crossref 9. Fiasse R, Hamin C, Lepot A, et al: Controlled trial of cimetidine in reflux esophagitis. Dig Dis Sci 1980;25:750-755.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1982

References