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Beta Carotene Treatment and Erythrocytic Protoporphyrin Levels

Beta Carotene Treatment and Erythrocytic Protoporphyrin Levels Abstract To the Editor.— To determine if long-term beta carotene therapy of erythropoietic protoporphyria (EPP) had any effect on protoporphyrin levels, we have performed statistical analyses of all of the erythrocytic protoporphyrin concentrations of 44 patients with EPP who had participated for at least two years in our study of beta carotene therapy of this disease.1,2 For each patient, the data included protoporphyrin concentrations that were determined when patients were and were not ingesting beta carotene, and during summer-time (June to September) and winter-time (October to May).The level of erythrocytic protoporphyrin concentration varied widely for each patient over time and varied widely between patients. Since the values for protoporphyrin (P) were not normally distributed, but the log transformations were so distributed, the natural log transformations of the concentrations (log [RBC — P]) were used in the analysis.We first assessed the effect of the season on concentration of protoporphyrin References 1. Mathews-Roth MM, Pathak MA, Fitzpatrick TB, et al: Beta-carotene as an oral photoprotective agent in erythropoietic protoporphyria . JAMA 228:1004-1008, 1974.Crossref 2. Mathews-Roth MM, Pathak MA, Fitzpatrick TB, et al: Beta-carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases . Arch Dermatol 113:1229-1232, 1977.Crossref 3. Snedecor WG, Cochran WG: Statistical Methods . Ames, Iowa, Iowa State University Press, 1967. 4. Everett MA, Yeargers E, Sayre RM, et al: Penetration of epidermis by ultra violet rays . Photochem Photobiol 5:533-542, 1966.Crossref 5. Piomelli S, Lamola AA, Poh-Fitzpatrick MB, et al: Erythropoietic protoporphyria and lead intoxication: The molecular basis for difference in cutaneous photosensitivity: I. Different rates of disappearance of protoporphyrin from the erythrocytes, both in vivo and in vitro . J Clin Invest 56:1519-1527, 1975.Crossref 6. Harber LC, Fleischer A, Baer RL: Photohemolysis associated with protoporphyrinemia . J Invest Dermatol 42:483-485, 1964.Crossref 7. Poh-Fitzpatrick MB, DeLeo VA: Rates of plasma porphyrin disappearance in fluorescent vs red incandescent light exposure . J Invest Dermatol 69:510-512, 1977.Crossref 8. Poh-Fitzpatrick MB, Lamola A: Comparative study of protoporphyrins in erythropoietic protoporphyria and griseofulvin-induced murine protoporphyria: Binding affinities, distribution and fluorescence spectra in various blood fractions . J Clin Invest 60:380-389, 1977.Crossref 9. Swanbeck G, Wennersten G: Effect of beta-carotene on photohemolysis . Acta Derm Venerol 53:282-289, 1973. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Beta Carotene Treatment and Erythrocytic Protoporphyrin Levels

Beta Carotene Treatment and Erythrocytic Protoporphyrin Levels

Abstract

Abstract To the Editor.— To determine if long-term beta carotene therapy of erythropoietic protoporphyria (EPP) had any effect on protoporphyrin levels, we have performed statistical analyses of all of the erythrocytic protoporphyrin concentrations of 44 patients with EPP who had participated for at least two years in our study of beta carotene therapy of this disease.1,2 For each patient, the data included protoporphyrin concentrations that were determined when patients were and were...
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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1979.04010070004007
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— To determine if long-term beta carotene therapy of erythropoietic protoporphyria (EPP) had any effect on protoporphyrin levels, we have performed statistical analyses of all of the erythrocytic protoporphyrin concentrations of 44 patients with EPP who had participated for at least two years in our study of beta carotene therapy of this disease.1,2 For each patient, the data included protoporphyrin concentrations that were determined when patients were and were not ingesting beta carotene, and during summer-time (June to September) and winter-time (October to May).The level of erythrocytic protoporphyrin concentration varied widely for each patient over time and varied widely between patients. Since the values for protoporphyrin (P) were not normally distributed, but the log transformations were so distributed, the natural log transformations of the concentrations (log [RBC — P]) were used in the analysis.We first assessed the effect of the season on concentration of protoporphyrin References 1. Mathews-Roth MM, Pathak MA, Fitzpatrick TB, et al: Beta-carotene as an oral photoprotective agent in erythropoietic protoporphyria . JAMA 228:1004-1008, 1974.Crossref 2. Mathews-Roth MM, Pathak MA, Fitzpatrick TB, et al: Beta-carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases . Arch Dermatol 113:1229-1232, 1977.Crossref 3. Snedecor WG, Cochran WG: Statistical Methods . Ames, Iowa, Iowa State University Press, 1967. 4. Everett MA, Yeargers E, Sayre RM, et al: Penetration of epidermis by ultra violet rays . Photochem Photobiol 5:533-542, 1966.Crossref 5. Piomelli S, Lamola AA, Poh-Fitzpatrick MB, et al: Erythropoietic protoporphyria and lead intoxication: The molecular basis for difference in cutaneous photosensitivity: I. Different rates of disappearance of protoporphyrin from the erythrocytes, both in vivo and in vitro . J Clin Invest 56:1519-1527, 1975.Crossref 6. Harber LC, Fleischer A, Baer RL: Photohemolysis associated with protoporphyrinemia . J Invest Dermatol 42:483-485, 1964.Crossref 7. Poh-Fitzpatrick MB, DeLeo VA: Rates of plasma porphyrin disappearance in fluorescent vs red incandescent light exposure . J Invest Dermatol 69:510-512, 1977.Crossref 8. Poh-Fitzpatrick MB, Lamola A: Comparative study of protoporphyrins in erythropoietic protoporphyria and griseofulvin-induced murine protoporphyria: Binding affinities, distribution and fluorescence spectra in various blood fractions . J Clin Invest 60:380-389, 1977.Crossref 9. Swanbeck G, Wennersten G: Effect of beta-carotene on photohemolysis . Acta Derm Venerol 53:282-289, 1973.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1979

References