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Benzoyl Peroxide and Epidermal Wound Healing

Benzoyl Peroxide and Epidermal Wound Healing Abstract • The effectiveness of 10%, 20%, and 50% benzoyl peroxide in a lotion, 20% benzoyl peroxide in a gel, and the effect of the vehicles alone on wound reepithelialization were evaluated in young domestic pigs. Twenty percent benzoyl peroxide suspension in a lotion base substantially increased the rate of reepithelialization by 33% over a seven-day evaluation period. Twenty percent benzoyl peroxide suspension in a gel base and 10% benzoyl peroxide suspension in a lotion base slightly enhanced epidermal resurfacing, while 50% benzoyl peroxide suspension in a lotion base and the vehicle gel retarded healing. Variations in the rate of reepithelialization were observed when different lots of 20% benzoyl peroxide lotions were compared. Chemical analysis of each of the 20% benzoyl peroxide preparations tested disclosed great differences in zinc, magnesium, and sodium content. (Arch Dermatol 1983;119:222-225) References 1. Stecher PG (ed): The Merck Index of Chemicals and Drugs , ed 8. New Jersey, Merck & Co Inc, 1968, p 136. 2. Holzman J, Morscher B, Benes P: The absorption of benzoyl peroxide from leg ulcers . Arzneimittelforsch 1979;29:1180-1181. 3. Slaga TH, Klein-Szanto AJP, Triplett LL, et al: Skin tumorpromoting activity of benzoyl peroxide: Widely used free radical-generating compound . Science 1981;213:1023-1025.Crossref 4. Nacht S, Young D, Beasley JN, et al: Benzoyl peroxide: Percutaneous penetration and metabolic disposition . J Am Acad Dermatol 1981;4:31-37.Crossref 5. Hooft FV: Benzoyl peroxide , in Kirk RC (ed): Encyclopedia of Clinical Technology . New York, Interscience Publishers, 1948, p 479. 6. Lorenzetti OJ, Wernet T, McDonald T: Some comparisons of benzoyl peroxide formulations . J Soc Cosmet Chem 1977;28:533-549. 7. Mitchell-Heggs GB: Antibiotics in dermatology . Practitioner 1958;180:564-572. 8. Lamson PD: Benzoyl peroxide in the treatment of poison ivy intoxication . JAMA 1930;95:633.Crossref 9. Anderson AS, Goldye GJ, Green RC, et al: Improved reduction of cutaneous bacteria and free fatty acids with a new benzoyl peroxide gel . Cutis 1975;16:307-310. 10. Lyon RA, Reynolds TE: Promotion of healing by benzoyl peroxide and other agents . Proc Soc Exp Biol Med 1929;27:122-215.Crossref 11. Lynch WS, Bailin P: The promotion of wound healing following Chemosurgery (Mohs' technique) by dressings with a suspension of benzoyl peroxide . J Dermatol Surg Oncol 1978;4:91-95.Crossref 12. Colman GJ, Roenigk HH: The healing of wounds in the skin of piglets treated with benzoyl peroxide . J Dermatol Surg Oncol 1978;4:705-707.Crossref 13. Colman GJ, Roenigk HH: Topical therapy of leg ulcers with 20% benzoyl peroxide suspension . Cutis 1978;21:491-594. 14. Vogt DG, Valmassy RL: The therapeutic efficiency and pharmacologic actions of benzoyl peroxide on lower extremity ulcers . J Am Podiatry Assoc 1979;69:306-309.Crossref 15. Eaglstein WH, Mertz PM: New method for assessing epidermal wound healing: The effects of triamcinolone acetonide and polyethylene film occlusion . J Invest Dermatol 1978;71:382-384.Crossref 16. The United States Pharmacopeia , 20th revision. Rockville, Md, US Pharmacopeial Convention Inc, 1980, pp 75-76. 17. Weissman N, Pileggi VJ: Inorganic ions , in Henry RJ, Cannon DC, Winkelman JW (eds): Clinical Chemistry Principles and Techniques , ed 2. Hagerstown, Md, Harper & Row Publishers Inc, 1974, pp 639-754. 18. Doubleday D, Barkman A: Reading the Hegman grind gauge . Paint Oil Chem Rev 1950;133:34-39. 19. Steel RGD, Torrie JH: Comparisons involving two sample means , in Principles and Procedures of Statistics . New York, McGraw-Hill Book Co, 1960, pp 67-68. 20. Zar JH: The normal distribution , in Biostatistical Analysis . Englewood Cliffs, NJ, Prentice-Hall Inc, 1974, pp 70-85. 21. Eaglstein WH, Mertz PM: `Inert' vehicles do affect wound healing . J Invest Dermatol 1960;74:90-91.Crossref 22. Hallmans G: Absorption of topically applied zinc and changes in zinc metabolism during wound healing . Acta Derm Venereol 1978;80( (suppl 58) ):1-33. 23. Sanstead HJ, Lanier UC, Shepard GH, et al: Zinc and wound healing: Effect of zinc deficiency and zinc supplementations . Am J Clin Nutr 1970;23:514-519. 24. Williams KJ, Meltzer R, Brown RA, et al: The effect of topically applied zinc on the healing of open wounds . J Surg Res 1979;27:62-67.Crossref 25. Vihersaari T, Kivisaari J, Ninikoski J: Effect of changes in inspired oxygen tension on wound metabolism . Ann Surg 1974;179:889-895.Crossref 26. Hunt TK, Zederfeldt B: Nutritional and environmental aspects of wound healing , in Dunphy JE, Van Winkle W Jr (eds): Repair and Regeneration . New York, McGraw-Hill Book Co, 1969, p 217. 27. Kivisaari J, Vihersaari T, Renovall S, et al: Energy metabolism of experimental wounds at various oxygen environments . Ann Surg 1975;180:823-828.Crossref 28. Winter GD, Perrins DJD: Effects of hyperbaric oxygen treatments on epidermal regeneration , in Wada J, Ima T (eds): Proceedings of the Fourth International Congress on Hyperbaric Medicine . Tokyo, Igaku Shoin Ltd, 1970, p 363. 29. Geronemus RG, Mertz PM, Eaglstein WH: Wound healing: The effect of topical antimicrobial agents . Arch Dermatol 1979;115:1311-1313.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Benzoyl Peroxide and Epidermal Wound Healing

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1983.01650270040014
Publisher site
See Article on Publisher Site

Abstract

Abstract • The effectiveness of 10%, 20%, and 50% benzoyl peroxide in a lotion, 20% benzoyl peroxide in a gel, and the effect of the vehicles alone on wound reepithelialization were evaluated in young domestic pigs. Twenty percent benzoyl peroxide suspension in a lotion base substantially increased the rate of reepithelialization by 33% over a seven-day evaluation period. Twenty percent benzoyl peroxide suspension in a gel base and 10% benzoyl peroxide suspension in a lotion base slightly enhanced epidermal resurfacing, while 50% benzoyl peroxide suspension in a lotion base and the vehicle gel retarded healing. Variations in the rate of reepithelialization were observed when different lots of 20% benzoyl peroxide lotions were compared. Chemical analysis of each of the 20% benzoyl peroxide preparations tested disclosed great differences in zinc, magnesium, and sodium content. (Arch Dermatol 1983;119:222-225) References 1. Stecher PG (ed): The Merck Index of Chemicals and Drugs , ed 8. New Jersey, Merck & Co Inc, 1968, p 136. 2. Holzman J, Morscher B, Benes P: The absorption of benzoyl peroxide from leg ulcers . Arzneimittelforsch 1979;29:1180-1181. 3. Slaga TH, Klein-Szanto AJP, Triplett LL, et al: Skin tumorpromoting activity of benzoyl peroxide: Widely used free radical-generating compound . Science 1981;213:1023-1025.Crossref 4. Nacht S, Young D, Beasley JN, et al: Benzoyl peroxide: Percutaneous penetration and metabolic disposition . J Am Acad Dermatol 1981;4:31-37.Crossref 5. Hooft FV: Benzoyl peroxide , in Kirk RC (ed): Encyclopedia of Clinical Technology . New York, Interscience Publishers, 1948, p 479. 6. Lorenzetti OJ, Wernet T, McDonald T: Some comparisons of benzoyl peroxide formulations . J Soc Cosmet Chem 1977;28:533-549. 7. Mitchell-Heggs GB: Antibiotics in dermatology . Practitioner 1958;180:564-572. 8. Lamson PD: Benzoyl peroxide in the treatment of poison ivy intoxication . JAMA 1930;95:633.Crossref 9. Anderson AS, Goldye GJ, Green RC, et al: Improved reduction of cutaneous bacteria and free fatty acids with a new benzoyl peroxide gel . Cutis 1975;16:307-310. 10. Lyon RA, Reynolds TE: Promotion of healing by benzoyl peroxide and other agents . Proc Soc Exp Biol Med 1929;27:122-215.Crossref 11. Lynch WS, Bailin P: The promotion of wound healing following Chemosurgery (Mohs' technique) by dressings with a suspension of benzoyl peroxide . J Dermatol Surg Oncol 1978;4:91-95.Crossref 12. Colman GJ, Roenigk HH: The healing of wounds in the skin of piglets treated with benzoyl peroxide . J Dermatol Surg Oncol 1978;4:705-707.Crossref 13. Colman GJ, Roenigk HH: Topical therapy of leg ulcers with 20% benzoyl peroxide suspension . Cutis 1978;21:491-594. 14. Vogt DG, Valmassy RL: The therapeutic efficiency and pharmacologic actions of benzoyl peroxide on lower extremity ulcers . J Am Podiatry Assoc 1979;69:306-309.Crossref 15. Eaglstein WH, Mertz PM: New method for assessing epidermal wound healing: The effects of triamcinolone acetonide and polyethylene film occlusion . J Invest Dermatol 1978;71:382-384.Crossref 16. The United States Pharmacopeia , 20th revision. Rockville, Md, US Pharmacopeial Convention Inc, 1980, pp 75-76. 17. Weissman N, Pileggi VJ: Inorganic ions , in Henry RJ, Cannon DC, Winkelman JW (eds): Clinical Chemistry Principles and Techniques , ed 2. Hagerstown, Md, Harper & Row Publishers Inc, 1974, pp 639-754. 18. Doubleday D, Barkman A: Reading the Hegman grind gauge . Paint Oil Chem Rev 1950;133:34-39. 19. Steel RGD, Torrie JH: Comparisons involving two sample means , in Principles and Procedures of Statistics . New York, McGraw-Hill Book Co, 1960, pp 67-68. 20. Zar JH: The normal distribution , in Biostatistical Analysis . Englewood Cliffs, NJ, Prentice-Hall Inc, 1974, pp 70-85. 21. Eaglstein WH, Mertz PM: `Inert' vehicles do affect wound healing . J Invest Dermatol 1960;74:90-91.Crossref 22. Hallmans G: Absorption of topically applied zinc and changes in zinc metabolism during wound healing . Acta Derm Venereol 1978;80( (suppl 58) ):1-33. 23. Sanstead HJ, Lanier UC, Shepard GH, et al: Zinc and wound healing: Effect of zinc deficiency and zinc supplementations . Am J Clin Nutr 1970;23:514-519. 24. Williams KJ, Meltzer R, Brown RA, et al: The effect of topically applied zinc on the healing of open wounds . J Surg Res 1979;27:62-67.Crossref 25. Vihersaari T, Kivisaari J, Ninikoski J: Effect of changes in inspired oxygen tension on wound metabolism . Ann Surg 1974;179:889-895.Crossref 26. Hunt TK, Zederfeldt B: Nutritional and environmental aspects of wound healing , in Dunphy JE, Van Winkle W Jr (eds): Repair and Regeneration . New York, McGraw-Hill Book Co, 1969, p 217. 27. Kivisaari J, Vihersaari T, Renovall S, et al: Energy metabolism of experimental wounds at various oxygen environments . Ann Surg 1975;180:823-828.Crossref 28. Winter GD, Perrins DJD: Effects of hyperbaric oxygen treatments on epidermal regeneration , in Wada J, Ima T (eds): Proceedings of the Fourth International Congress on Hyperbaric Medicine . Tokyo, Igaku Shoin Ltd, 1970, p 363. 29. Geronemus RG, Mertz PM, Eaglstein WH: Wound healing: The effect of topical antimicrobial agents . Arch Dermatol 1979;115:1311-1313.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Mar 1, 1983

References