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Benignity of Neonatal Tumors

Benignity of Neonatal Tumors Abstract To the Editor. —We would like to add a postscript to the discussion on the benign nature of neonatal cancer.1 It may be that acute lymphoblastic leukemia can be added to the list of diseases mentioned. This disease is distinctly uncommon in infants under 1 year, accounting for less than 10% of all cases. The incidence then rises steeply to a peak at 3 years. This pattern is not seen in the rare childhood cases of acute myeloblastic leukemia where there is no particular age distribution.Court Brown and Doll2 postulated that the peak was due to a latent period required for some unknown etiologic agent to exert its full effect. It may be, however, that passive immunologic factors keep the disease at bay in early life.Supporting evidence for this concept grows: in Burkitt lymphoma the period of protection extends for a longer time than in other References 1. Lowry WS, Bolande RP: Benignity of neonatal tumors . Am J Dis Child 123:85-86, 1972. 2. Court Brown WM, Doll R: Leukemia in childhood . Br Med J 1:981-988, 1961.Crossref 3. Pierce ML, et al: Epidemiology and survival in leukemia . Cancer 23:1296-1302, 1969.Crossref 4. Seidman H: Cancer of the breast . Cancer 24:1355-1378, 1969.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Benignity of Neonatal Tumors

Abstract

Abstract To the Editor. —We would like to add a postscript to the discussion on the benign nature of neonatal cancer.1 It may be that acute lymphoblastic leukemia can be added to the list of diseases mentioned. This disease is distinctly uncommon in infants under 1 year, accounting for less than 10% of all cases. The incidence then rises steeply to a peak at 3 years. This pattern is not seen in the rare childhood cases of acute myeloblastic leukemia where there is no particular age...
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Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1973.04160030110027
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —We would like to add a postscript to the discussion on the benign nature of neonatal cancer.1 It may be that acute lymphoblastic leukemia can be added to the list of diseases mentioned. This disease is distinctly uncommon in infants under 1 year, accounting for less than 10% of all cases. The incidence then rises steeply to a peak at 3 years. This pattern is not seen in the rare childhood cases of acute myeloblastic leukemia where there is no particular age distribution.Court Brown and Doll2 postulated that the peak was due to a latent period required for some unknown etiologic agent to exert its full effect. It may be, however, that passive immunologic factors keep the disease at bay in early life.Supporting evidence for this concept grows: in Burkitt lymphoma the period of protection extends for a longer time than in other References 1. Lowry WS, Bolande RP: Benignity of neonatal tumors . Am J Dis Child 123:85-86, 1972. 2. Court Brown WM, Doll R: Leukemia in childhood . Br Med J 1:981-988, 1961.Crossref 3. Pierce ML, et al: Epidemiology and survival in leukemia . Cancer 23:1296-1302, 1969.Crossref 4. Seidman H: Cancer of the breast . Cancer 24:1355-1378, 1969.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Mar 1, 1973

References