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T. Shepard (1973)
Catalog of Teratogenic Agents
In Reply.— My article referred to the large body of epidemiologic research, which has found no association between Bendectin and birth defects. As Richard Leavitt, director of science information for the March of Dimes Birth Defects Foundation, said, Bendectin has been the best-studied drug used in pregnancy, "and the great preponderance of evidence generally exonerates it from any harmful effect." Strictly speaking, Dr Newman is right to say that these studies are inconclusive. As the tobacco industry is fond of telling us, epidemiologic studies can never prove cause and effect with absolute certainty; they are even less able to prove the absence of a cause-and-effect relationship. Epidemiologic studies, however, are the only ethical way we
JAMA – American Medical Association
Published: Aug 1, 1990
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