Abstract THOUGH there remains doubt as to the mechanism of production of the urticarial wheal and other reactions of allergy, most of the recent work has been based on assumption that such reactions are mediated by histamine or an H substance. Attempts at therapeutic desensitization toward histamine have utilized histamine as well as a conjugated hapten, but this approach has been time consuming and not uniformly successful. Because of its antihistamine effect Curtis and Owens1 recently called attention to betadimethylaminoethyl benzhydryl ether hydrochloride (Benadryl),2 which they used in the treatment of acute and chronic urticaria. The drug is many times more effective than theophylline ethylenediamine. in alleviating histamine shock and anaphylactic shock in the guinea pig.3 It appears to reduce bronchoconstriction, abolish vasodepressor effects and exert an antispasmodic action. Toxic effects are few and were reviewed by Curtis and Owens in their report on treatment of 18 patients References 1. Curtis, A. C., and Owens, B. B.: Beta-Dimethylaminoethyl Benzhydryl Ether Hydrochloride (Benadryl) in Treatment of Acute and Chronic Urticaria , Univ. Hosp. Bull., Ann Arbor 11:25 ( (April) ) 1945. 2. The name "Benadryl" has been applied by Parke, Davis and Company to the following drug: beta dimethylaminoethyl benzhydryl ether hydrochloride. For this study generous supplies of the drug were made available by Mr. Paul S. Denn of the Medical Service and Dr. E. A. Sharp of the Department of Clinical Investigation of Parke, Davis and Company. 3. Loew, E. R.; Kaiser, M. E., and Moore, V.: Synthetic Benzhydryl Alkamine Ethers Effective in Preventing Fatal Experimental Asthma in Guinea Pigs Exposed to Atomized Histamine , J. Pharmacol. & Exper. Therap. 83:120 ( (Feb.) ) 1945. 4. Loew, E. R., and Kaiser, M. E.: Alleviation of Anaphylactic Shock in Guinea Pigs with Synthetic Benzhydryl Alkamine Ethers , Proc. Soc. Exper. Biol. & Med. 58:235 ( (March) ) 1945.
Archives of Dermatology and Syphilology – American Medical Association
Published: Jan 1, 1947