Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Bempedoic Acid for Lowering LDL Cholesterol

Bempedoic Acid for Lowering LDL Cholesterol Opinion EDITORIAL Michael C. Honigberg, MD, MPP; Pradeep Natarajan, MD, MMSc Since the report of the first expert panel of the National Cho- with placebo), and there was similarly no significant excess lesterol Education Program in 1988, effectively the first con- of muscle symptoms compared with placebo within 12 temporary professional cholesterol guidelines in the United months. While not designed to evaluate cardiovascular out- States, lowering of low-density lipoprotein cholesterol comes, CLEAR Harmony showed nonsignificantly fewer (LDL-C) levels has been a major adverse cardiovascular events with bempedoic acid cornerstone of atheroscle- (4.6%) vs placebo (5.7%) during this time frame. Related article page 1780 rotic cardiovascular disease In this context, Goldberg et al report in this issue of (ASCVD) prevention. Consistent with classical and genetic JAMA findings on the LDL-C–lowering efficacy and adverse epidemiologic studies implying a causal relationship effects of bempedoic acid (180 mg daily) in the similarly between LDL-C and ASCVD, multiple randomized clinical designed CLEAR Wisdom trial that included 779 patients. trials have consistently observed proportional relationships Trial-eligible individuals had heterozygous familial hyper- between LDL-C lowering and ASCVD risk reduction from stat- cholesterolemia (5.5%) or ASCVD (94.5%), were taking ins. More recently, these findings have extended to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Bempedoic Acid for Lowering LDL Cholesterol

JAMA , Volume 322 (18) – Nov 12, 2019

Loading next page...
 
/lp/american-medical-association/bempedoic-acid-for-lowering-ldl-cholesterol-3vhpOvBj10
Publisher
American Medical Association
Copyright
Copyright 2019 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2019.16598
Publisher site
See Article on Publisher Site

Abstract

Opinion EDITORIAL Michael C. Honigberg, MD, MPP; Pradeep Natarajan, MD, MMSc Since the report of the first expert panel of the National Cho- with placebo), and there was similarly no significant excess lesterol Education Program in 1988, effectively the first con- of muscle symptoms compared with placebo within 12 temporary professional cholesterol guidelines in the United months. While not designed to evaluate cardiovascular out- States, lowering of low-density lipoprotein cholesterol comes, CLEAR Harmony showed nonsignificantly fewer (LDL-C) levels has been a major adverse cardiovascular events with bempedoic acid cornerstone of atheroscle- (4.6%) vs placebo (5.7%) during this time frame. Related article page 1780 rotic cardiovascular disease In this context, Goldberg et al report in this issue of (ASCVD) prevention. Consistent with classical and genetic JAMA findings on the LDL-C–lowering efficacy and adverse epidemiologic studies implying a causal relationship effects of bempedoic acid (180 mg daily) in the similarly between LDL-C and ASCVD, multiple randomized clinical designed CLEAR Wisdom trial that included 779 patients. trials have consistently observed proportional relationships Trial-eligible individuals had heterozygous familial hyper- between LDL-C lowering and ASCVD risk reduction from stat- cholesterolemia (5.5%) or ASCVD (94.5%), were taking ins. More recently, these findings have extended to

Journal

JAMAAmerican Medical Association

Published: Nov 12, 2019

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month