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The results of the use of the BCG vaccine in man are influenced by so many factors that accurate evaluation is still difficult. All reports agree that the vaccine properly prepared and used is harmless, as cases of tuberculosis caused by BCG vaccine have not been reported thus far. In some cases in which vaccinated children developed and died of tuberculosis, the bacilli from the pleural exudate, cerebrospinal fluid and lungs were of the human and not the bovine type. Holm1 of Denmark states that since 1940 vaccination with the bacillus of Calmette-Guérin has been adopted in that country as an essential weapon in the fight against tuberculosis. A large part of the young people of Denmark are tuberculin negative. Since it is known that tuberculin negative persons acquire tuberculosis much more readily when exposed, BCG vaccination is believed to be a valuable adjunct in the control of tuberculosis.
JAMA – American Medical Association
Published: Nov 9, 1946
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