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Letters vestigating hypothermia treatment in bacterial meningitis the inclusion rate was low, but it was homogenous among all should include more precise inclusion criteria such as objec- active centers, excluding selection bias. tive intracranial pressure status. The duration of the disease is almost impossible to assess because timing of the infection is unknown. Nevertheless, once Marko Kutleša, MD, PhD patients were referred to the hospital, we found no signifi- Dragan Lepur, MD, PhD cant difference in time from door to first dose of antibiotics. Bruno Baršić, MD, PhD Knaus chronic health status score and McCabe classification were also similar in the 2 groups. Author Affiliations: Department of Intensive Care Medicine and We acknowledge that the chosen duration (48 hours) Neuroinfectology, University Hospital for Infectious Diseases “Dr Fran of therapeutic hypothermia was arbitrary. This period corre- Mihaljević,” Zagreb, Croatia. sponds to the maximum inflammatory response into the Corresponding Author: Marko Kutleša, MD, PhD, University Hospital for cerebrospinal fluid. Monitoring intracranial pressure could Infectious Diseases “Dr Fran Mihaljević,” Mirogojska 8, Zagreb 10000, Croatia (mkutlesa@bfm.hr). have helped to guide the hypothermia duration. Conflict of Interest Disclosures: The authors have completed and submitted Nevertheless, the use of this technique could have pre- the
JAMA – American Medical Association
Published: Apr 2, 2014
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