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Basic Science Content in the USMLE Step 1—Reply

Basic Science Content in the USMLE Step 1—Reply Letters vestigating hypothermia treatment in bacterial meningitis the inclusion rate was low, but it was homogenous among all should include more precise inclusion criteria such as objec- active centers, excluding selection bias. tive intracranial pressure status. The duration of the disease is almost impossible to assess because timing of the infection is unknown. Nevertheless, once Marko Kutleša, MD, PhD patients were referred to the hospital, we found no signifi- Dragan Lepur, MD, PhD cant difference in time from door to first dose of antibiotics. Bruno Baršić, MD, PhD Knaus chronic health status score and McCabe classification were also similar in the 2 groups. Author Affiliations: Department of Intensive Care Medicine and We acknowledge that the chosen duration (48 hours) Neuroinfectology, University Hospital for Infectious Diseases “Dr Fran of therapeutic hypothermia was arbitrary. This period corre- Mihaljević,” Zagreb, Croatia. sponds to the maximum inflammatory response into the Corresponding Author: Marko Kutleša, MD, PhD, University Hospital for cerebrospinal fluid. Monitoring intracranial pressure could Infectious Diseases “Dr Fran Mihaljević,” Mirogojska 8, Zagreb 10000, Croatia (mkutlesa@bfm.hr). have helped to guide the hypothermia duration. Conflict of Interest Disclosures: The authors have completed and submitted Nevertheless, the use of this technique could have pre- the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Basic Science Content in the USMLE Step 1—Reply

JAMA , Volume 311 (13) – Apr 2, 2014

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References (6)

Publisher
American Medical Association
Copyright
Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2014.1186
pmid
24691621
Publisher site
See Article on Publisher Site

Abstract

Letters vestigating hypothermia treatment in bacterial meningitis the inclusion rate was low, but it was homogenous among all should include more precise inclusion criteria such as objec- active centers, excluding selection bias. tive intracranial pressure status. The duration of the disease is almost impossible to assess because timing of the infection is unknown. Nevertheless, once Marko Kutleša, MD, PhD patients were referred to the hospital, we found no signifi- Dragan Lepur, MD, PhD cant difference in time from door to first dose of antibiotics. Bruno Baršić, MD, PhD Knaus chronic health status score and McCabe classification were also similar in the 2 groups. Author Affiliations: Department of Intensive Care Medicine and We acknowledge that the chosen duration (48 hours) Neuroinfectology, University Hospital for Infectious Diseases “Dr Fran of therapeutic hypothermia was arbitrary. This period corre- Mihaljević,” Zagreb, Croatia. sponds to the maximum inflammatory response into the Corresponding Author: Marko Kutleša, MD, PhD, University Hospital for cerebrospinal fluid. Monitoring intracranial pressure could Infectious Diseases “Dr Fran Mihaljević,” Mirogojska 8, Zagreb 10000, Croatia (mkutlesa@bfm.hr). have helped to guide the hypothermia duration. Conflict of Interest Disclosures: The authors have completed and submitted Nevertheless, the use of this technique could have pre- the

Journal

JAMAAmerican Medical Association

Published: Apr 2, 2014

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