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Basal Cell Carcinoma Occurring in Multiple Familial Trichoepithelioma: Detection of Loss of Heterozygosity in Chromosome 9q

Basal Cell Carcinoma Occurring in Multiple Familial Trichoepithelioma: Detection of Loss of... Abstract Basal cell carcinoma (BCC) occasionally arises from the preexisting lesions of multiple familial trichoepithelioma (MFT).1 The gene for BCC has been assigned to chromosome 9q22.3-q31,2 and the gene for Bazex-Dupré-Christol syndrome, characterized by the early onset of multiple BCCs, has been mapped to chromosome Xq24-q27.1.3 Recently, we carried out a linkage analysis in 3 families with MFT and mapped the gene for MFT to chromosome 9p21.4 Therefore, trichoepithelioma does not seem to be allelic with BCC despite their histological similarities. To assess the involvement of the BCC genes in the development of BCC in MFT lesions, we examined the possibility of loss of heterozygosity in 2 different BCC specimens from the same patient using microsatellite markers of chromosomes 9q22-q31, Xq24-q27, and 9p21. Only the markers of chromosome 9q22-q31, the locus for sporadic BCCs and nevoid BCC syndrome, showed loss of heterozygosity in 1 of the 2 References 1. Johnson SC, Bennett RG. Occurrence of basal cell carcinoma among multiple trichoepitheliomas . J Am Acad Dermatol. 1993;28:322-326.Crossref 2. Bale AE, Gailani MR, Leffell DJ. Nevoid basal cell carcinoma syndrome . J Invest Dermatol. 1994;103( (suppl) ):126S-130S.Crossref 3. Vabres P, Lacombe D, Rabinowitz LG, et al. The gene for Bazex-Dupré-Christol syndrome maps to chromosome Xq . J Invest Dermatol. 1995;105: 87-91.Crossref 4. Harada H, Hashimoto K, Ko MSH. The gene for multiple familial trichoepithelioma maps to chromosome 9p21 . J Invest Dermatol. 1996;107:41-43.Crossref 5. Gailani MR, Stahle-Backdahl M, Leffell DJ, et al. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas . Nature Genet. 1996;14:78-81.Crossref 6. Quinn AG, Sikkink S, Rees JL. Basal cell carcinoma and squamous cell carcinoma of human skin show distinct patterns of chromosome loss . Cancer Res. 1994;54:4756-4759. 7. Yuspa SH, Dlugosz M, Cheng CK, et al. Role of oncogenes and tumor suppressor genes in multistage carcinogenesis . J Invest Dermatol. 1994;103 ( (suppl) ):90S-95S.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Basal Cell Carcinoma Occurring in Multiple Familial Trichoepithelioma: Detection of Loss of Heterozygosity in Chromosome 9q

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Publisher
American Medical Association
Copyright
Copyright © 1997 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1997.03890410130027
Publisher site
See Article on Publisher Site

Abstract

Abstract Basal cell carcinoma (BCC) occasionally arises from the preexisting lesions of multiple familial trichoepithelioma (MFT).1 The gene for BCC has been assigned to chromosome 9q22.3-q31,2 and the gene for Bazex-Dupré-Christol syndrome, characterized by the early onset of multiple BCCs, has been mapped to chromosome Xq24-q27.1.3 Recently, we carried out a linkage analysis in 3 families with MFT and mapped the gene for MFT to chromosome 9p21.4 Therefore, trichoepithelioma does not seem to be allelic with BCC despite their histological similarities. To assess the involvement of the BCC genes in the development of BCC in MFT lesions, we examined the possibility of loss of heterozygosity in 2 different BCC specimens from the same patient using microsatellite markers of chromosomes 9q22-q31, Xq24-q27, and 9p21. Only the markers of chromosome 9q22-q31, the locus for sporadic BCCs and nevoid BCC syndrome, showed loss of heterozygosity in 1 of the 2 References 1. Johnson SC, Bennett RG. Occurrence of basal cell carcinoma among multiple trichoepitheliomas . J Am Acad Dermatol. 1993;28:322-326.Crossref 2. Bale AE, Gailani MR, Leffell DJ. Nevoid basal cell carcinoma syndrome . J Invest Dermatol. 1994;103( (suppl) ):126S-130S.Crossref 3. Vabres P, Lacombe D, Rabinowitz LG, et al. The gene for Bazex-Dupré-Christol syndrome maps to chromosome Xq . J Invest Dermatol. 1995;105: 87-91.Crossref 4. Harada H, Hashimoto K, Ko MSH. The gene for multiple familial trichoepithelioma maps to chromosome 9p21 . J Invest Dermatol. 1996;107:41-43.Crossref 5. Gailani MR, Stahle-Backdahl M, Leffell DJ, et al. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas . Nature Genet. 1996;14:78-81.Crossref 6. Quinn AG, Sikkink S, Rees JL. Basal cell carcinoma and squamous cell carcinoma of human skin show distinct patterns of chromosome loss . Cancer Res. 1994;54:4756-4759. 7. Yuspa SH, Dlugosz M, Cheng CK, et al. Role of oncogenes and tumor suppressor genes in multistage carcinogenesis . J Invest Dermatol. 1994;103 ( (suppl) ):90S-95S.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: May 1, 1997

References