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Basal Cell Carcinoma

Basal Cell Carcinoma EDITORIAL Still an Enigma T IS SOMETIMES a paradox in medicine that rare in a study of 24 sporadic BCCs, suggesting that a tumor conditions are intensively studied, while com- suppressor gene may be located on chromosome 9. Only mon conditions are often overlooked. Such has a small proportion of all patients with NMSC (2%-10%) 11-14 been the case with basal cell carcinoma (BCC). develop both BCC and SCC, and in individuals who I The public health burden of BCC is consider- develop a second tumor, the second tumor is generally able, yet the profile afforded to this cutaneous malig- of the same histogenetic type as the first tumor. nancy is low. This is surprising, as BCC is the most com- Among whites, Celtic ancestry is thought to in- 16,17 mon human cancer. It may be a reflection of the fact that crease the risk of skin cancer. Host factors, such as BCC has a very low mortality rate. Using mortality rates fair skin, blue eyes, red or fair hair, and inability to tan, as a measure of the importance of BCC in a population, were associated with an increased risk of NMSC in a num- 6,8,16,18-21 however, will http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/archderm.137.9.1239
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL Still an Enigma T IS SOMETIMES a paradox in medicine that rare in a study of 24 sporadic BCCs, suggesting that a tumor conditions are intensively studied, while com- suppressor gene may be located on chromosome 9. Only mon conditions are often overlooked. Such has a small proportion of all patients with NMSC (2%-10%) 11-14 been the case with basal cell carcinoma (BCC). develop both BCC and SCC, and in individuals who I The public health burden of BCC is consider- develop a second tumor, the second tumor is generally able, yet the profile afforded to this cutaneous malig- of the same histogenetic type as the first tumor. nancy is low. This is surprising, as BCC is the most com- Among whites, Celtic ancestry is thought to in- 16,17 mon human cancer. It may be a reflection of the fact that crease the risk of skin cancer. Host factors, such as BCC has a very low mortality rate. Using mortality rates fair skin, blue eyes, red or fair hair, and inability to tan, as a measure of the importance of BCC in a population, were associated with an increased risk of NMSC in a num- 6,8,16,18-21 however, will

Journal

JAMA DermatologyAmerican Medical Association

Published: Sep 1, 2001

References