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Bacteriological Studies in Pulmonary Atelectasis

Bacteriological Studies in Pulmonary Atelectasis Abstract Previous experiments in dogs demonstrated that the fever in experimental atelectasis was caused by sympathetic vasoconstriction stimulated by bacterial infection in the collapsed segment.1 The tachycardia was also of sympathetic origin, while the tachypnea was caused partly by bacterial infection and partly by the associated decreased arterial oxygen saturation and decreased lung volume. Certain questions remained to be answered, however. These included the importance of species variation; the role of inadvertant bronchial contamination at the time of plug insertion; and the effect of prolonged antibiotic administration on the bacterial flora in the atelectatic segment. The earlier bacteriological studies in dogs have been extended and observations in cats and humans added in an attempt to answer these problems. Methods The experimental animals were devocalized mongrel dogs of both sexes weighing 20 to 40 lb and cats of both sexes weighing 5 to 12 lb. Anesthesia was induced with hexobarbital, 15 References 1. Parke, Davis & Co. 2. Lansing, A. M., and Jamieson, W. G.: Mechanisms of Fever in Pulmonary Atelectasis , Arch Surg 87:168, 1963.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Bacteriological Studies in Pulmonary Atelectasis

Archives of Surgery , Volume 87 (6) – Dec 1, 1963

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Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1963.01310180178030
Publisher site
See Article on Publisher Site

Abstract

Abstract Previous experiments in dogs demonstrated that the fever in experimental atelectasis was caused by sympathetic vasoconstriction stimulated by bacterial infection in the collapsed segment.1 The tachycardia was also of sympathetic origin, while the tachypnea was caused partly by bacterial infection and partly by the associated decreased arterial oxygen saturation and decreased lung volume. Certain questions remained to be answered, however. These included the importance of species variation; the role of inadvertant bronchial contamination at the time of plug insertion; and the effect of prolonged antibiotic administration on the bacterial flora in the atelectatic segment. The earlier bacteriological studies in dogs have been extended and observations in cats and humans added in an attempt to answer these problems. Methods The experimental animals were devocalized mongrel dogs of both sexes weighing 20 to 40 lb and cats of both sexes weighing 5 to 12 lb. Anesthesia was induced with hexobarbital, 15 References 1. Parke, Davis & Co. 2. Lansing, A. M., and Jamieson, W. G.: Mechanisms of Fever in Pulmonary Atelectasis , Arch Surg 87:168, 1963.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Dec 1, 1963

References