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Bacterial Endophthalmitis: Treatment With Intraocular Injection of Gentamicin and Dexamethasone

Bacterial Endophthalmitis: Treatment With Intraocular Injection of Gentamicin and Dexamethasone Abstract Bacterial endophthalmitis was diagnosed clinically in a patient who developed ocular inflammation three days after uneventful intracapsular cataract extraction. Aqueous humor aspirations revealed Gram-negative rods. Culture of the aqueous humor showed the organism to be Proteus morgagnii. Because of rapid progression of endophthalmitis, a solution containing 0.4 mg of gentamicin sulfate and 0.4 mg of dexamethasone was injected into the vitreous and anterior chamber. Subsequently, there was a substantial improvement in the clinical course. The vision improved from light perception to 5/200 with corrective lenses. The electroretinogram was normal. References 1. Allen HF, Mangiaracine AB: Bacterial endophthalmitis after cataract extraction: A study of 22 infections in 20,000 operations . Arch Ophthalmol 72:454-462, 1964.Crossref 2. Burns RP: Postoperative infections in an ophthalmologic hospital . Am J Ophthalmol 48:519-526, 1959. 3. Neveu M, Elliot AJ: Prophylaxis and treatment of endophthalmitis . Am J Ophthalmol 48:368-373, 1959. 4. Maylath FR, Leopold IH: Study of experimental intraocular infections . Am J Ophthalmol 40:86-101, 1955. 5. Leopold IH, Apt L: Postoperative intraocular infections . Am J Ophthalmol 50:1225-1247, 1960. 6. Deuer HA, Maas ER: The penetration of several new penicillins into the tissues of the eye . Ophthalmologica 144:316-322, 1962.Crossref 7. Golden B, Coppel SP: Ocular tissue absorption of gentamicin . Arch Ophthalmol 84:792-796, 1970.Crossref 8. Litwack KD, Pettit T, Johnson BL Jr: Penetration of gentamicin: Administered intramuscularly and subconjunctivally into aqueous humor . Arch Ophthalmol 82:687-693, 1969.Crossref 9. Kurose Y, Sery TW, Leopold IH: Intraocular penetration of Thiosporin . Am J Ophthalmol 57:418-426, 1964. 10. Leopold IH: Intravitreal penetration of penicillin and penicillin therapy of infections of the vitreous . Arch Ophthalmol 33:211-216, 1945.Crossref 11. von Sallman L, Meyer K, Di Grandi J: Experimental study of penicillin treatment of ectogenous infection of vitreous . Arch Ophthalmol 32:179-189, 1944.Crossref 12. Peyman GA, et al: Intraocular injection of gentamicin: Toxicity and clearance. Arch Ophthalmol, to be published. 13. May DR, et al: Therapeutic efficacy of intraocular injection of gentamicin for bacterial endophthalmitis. Arch Ophthalmol, to be published. 14. Graham RO, Peyman GA: Intraocular injection of dexamethasone. Arch Ophthalmol, to be published. 15. Allen HF, Mangiaracine AB: Bacterial endophthalmitis after cataract extraction: II. Incidence in 36,000 consecutive operations with special reference to preoperative topical antibiotics . Arch Ophthalmol 91:3-7, 1974.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Bacterial Endophthalmitis: Treatment With Intraocular Injection of Gentamicin and Dexamethasone

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Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1974.03900060428017
Publisher site
See Article on Publisher Site

Abstract

Abstract Bacterial endophthalmitis was diagnosed clinically in a patient who developed ocular inflammation three days after uneventful intracapsular cataract extraction. Aqueous humor aspirations revealed Gram-negative rods. Culture of the aqueous humor showed the organism to be Proteus morgagnii. Because of rapid progression of endophthalmitis, a solution containing 0.4 mg of gentamicin sulfate and 0.4 mg of dexamethasone was injected into the vitreous and anterior chamber. Subsequently, there was a substantial improvement in the clinical course. The vision improved from light perception to 5/200 with corrective lenses. The electroretinogram was normal. References 1. Allen HF, Mangiaracine AB: Bacterial endophthalmitis after cataract extraction: A study of 22 infections in 20,000 operations . Arch Ophthalmol 72:454-462, 1964.Crossref 2. Burns RP: Postoperative infections in an ophthalmologic hospital . Am J Ophthalmol 48:519-526, 1959. 3. Neveu M, Elliot AJ: Prophylaxis and treatment of endophthalmitis . Am J Ophthalmol 48:368-373, 1959. 4. Maylath FR, Leopold IH: Study of experimental intraocular infections . Am J Ophthalmol 40:86-101, 1955. 5. Leopold IH, Apt L: Postoperative intraocular infections . Am J Ophthalmol 50:1225-1247, 1960. 6. Deuer HA, Maas ER: The penetration of several new penicillins into the tissues of the eye . Ophthalmologica 144:316-322, 1962.Crossref 7. Golden B, Coppel SP: Ocular tissue absorption of gentamicin . Arch Ophthalmol 84:792-796, 1970.Crossref 8. Litwack KD, Pettit T, Johnson BL Jr: Penetration of gentamicin: Administered intramuscularly and subconjunctivally into aqueous humor . Arch Ophthalmol 82:687-693, 1969.Crossref 9. Kurose Y, Sery TW, Leopold IH: Intraocular penetration of Thiosporin . Am J Ophthalmol 57:418-426, 1964. 10. Leopold IH: Intravitreal penetration of penicillin and penicillin therapy of infections of the vitreous . Arch Ophthalmol 33:211-216, 1945.Crossref 11. von Sallman L, Meyer K, Di Grandi J: Experimental study of penicillin treatment of ectogenous infection of vitreous . Arch Ophthalmol 32:179-189, 1944.Crossref 12. Peyman GA, et al: Intraocular injection of gentamicin: Toxicity and clearance. Arch Ophthalmol, to be published. 13. May DR, et al: Therapeutic efficacy of intraocular injection of gentamicin for bacterial endophthalmitis. Arch Ophthalmol, to be published. 14. Graham RO, Peyman GA: Intraocular injection of dexamethasone. Arch Ophthalmol, to be published. 15. Allen HF, Mangiaracine AB: Bacterial endophthalmitis after cataract extraction: II. Incidence in 36,000 consecutive operations with special reference to preoperative topical antibiotics . Arch Ophthalmol 91:3-7, 1974.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1974

References

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