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Axonal Transport Interruption and Anatomy at the Lamina Cribrosa

Axonal Transport Interruption and Anatomy at the Lamina Cribrosa Abstract • Pressure-induced, focal axonal transport abnormalities were studied in 14 cat eyes by the examination of serial step-section tissue radioautogram. Although the patterns of the transport interruption at the lamina cribrosa varied from eye to eye, the temporal sectors of the nerve head were most often involved by this abnormality. The anatomy at the lamina cribrosa was studied in adjacent (6-μm) cross-sectional specimens. The thickness of the extra-bundle trabeculae and the nerve fiber bundle dimensions including the cross-sectional area and the number and the shape (the ratio of the major and the minor axis diameters) of the laminar pores were measured by computer-assisted perimeter analysis. There was no correlation between the location of the transport interruption and any of these anatomic measurements. References 1. Quigley HA, Addicks EM: Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage . Arch Ophthalmol 1981;99:137-143.Crossref 2. Radius RL: Regional specificity in anatomy at the lamina cribrosa . Arch Ophthalmol 1981;99:478-480.Crossref 3. Radius RL, Gonzales M: Anatomy at the lamina cribrosa in human eyes . Arch Ophthalmol 1981;99:2159-2162.Crossref 4. Radius RL, Maumenee AE, Green WR: Pit-like changes of the optic nerve head in openangle glaucoma . Br J Ophthalmol 1978;62:389-393.Crossref 5. Quigley HA, Anderson DR: Distribution of axonal transport blockade by acute intraocular pressure elevation in the primate optic nerve head . Invest Ophthalmol Vis Sci 1977;16:640-644. 6. Minckler DS, Bunt AH, Johanson GW: Orthograde and retrograde axoplasmic transport during acute ocular hypertension in the monkey . Invest Ophthalmol Vis Sci 1977;16:426-441. 7. Radius RL: Distribution of pressure-induced fast axonal transport abnormalities in primate optic nerve: An autoradiographic study . Arch Ophthalmol 1981;99:1253-1257.Crossref 8. Radius RL, Bade B: Pressure-induced optic nerve axonal transport interruption in cat eyes . Arch Ophthalmol 1981;99:2163-2165.Crossref 9. Radius RL, Anderson DR: Breakdown of the normal optic nerve head blood-brain barrier following acute elevation of intraocular pressure in experimental animals . Invest Ophthalmol Vis Sci 1980;19:244-255. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Axonal Transport Interruption and Anatomy at the Lamina Cribrosa

Archives of Ophthalmology , Volume 100 (10) – Oct 1, 1982

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1982.01030040639017
Publisher site
See Article on Publisher Site

Abstract

Abstract • Pressure-induced, focal axonal transport abnormalities were studied in 14 cat eyes by the examination of serial step-section tissue radioautogram. Although the patterns of the transport interruption at the lamina cribrosa varied from eye to eye, the temporal sectors of the nerve head were most often involved by this abnormality. The anatomy at the lamina cribrosa was studied in adjacent (6-μm) cross-sectional specimens. The thickness of the extra-bundle trabeculae and the nerve fiber bundle dimensions including the cross-sectional area and the number and the shape (the ratio of the major and the minor axis diameters) of the laminar pores were measured by computer-assisted perimeter analysis. There was no correlation between the location of the transport interruption and any of these anatomic measurements. References 1. Quigley HA, Addicks EM: Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage . Arch Ophthalmol 1981;99:137-143.Crossref 2. Radius RL: Regional specificity in anatomy at the lamina cribrosa . Arch Ophthalmol 1981;99:478-480.Crossref 3. Radius RL, Gonzales M: Anatomy at the lamina cribrosa in human eyes . Arch Ophthalmol 1981;99:2159-2162.Crossref 4. Radius RL, Maumenee AE, Green WR: Pit-like changes of the optic nerve head in openangle glaucoma . Br J Ophthalmol 1978;62:389-393.Crossref 5. Quigley HA, Anderson DR: Distribution of axonal transport blockade by acute intraocular pressure elevation in the primate optic nerve head . Invest Ophthalmol Vis Sci 1977;16:640-644. 6. Minckler DS, Bunt AH, Johanson GW: Orthograde and retrograde axoplasmic transport during acute ocular hypertension in the monkey . Invest Ophthalmol Vis Sci 1977;16:426-441. 7. Radius RL: Distribution of pressure-induced fast axonal transport abnormalities in primate optic nerve: An autoradiographic study . Arch Ophthalmol 1981;99:1253-1257.Crossref 8. Radius RL, Bade B: Pressure-induced optic nerve axonal transport interruption in cat eyes . Arch Ophthalmol 1981;99:2163-2165.Crossref 9. Radius RL, Anderson DR: Breakdown of the normal optic nerve head blood-brain barrier following acute elevation of intraocular pressure in experimental animals . Invest Ophthalmol Vis Sci 1980;19:244-255.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Oct 1, 1982

References