Abstract IN ORDER to avoid complete loss of adrenocortical function following total adrenalectomy for Cushing's disease (bilateral adrenocortical hyperplasia), autotransplantation of excised tissue to a readily accessible site has been done on several occasions. Franksson et al1 described five cases of Cushing's disease in which large fragments of adrenal tissue were implanted into the sartorius muscle. Evidence was obtained in one patient that the autotransplant was histologically normal and also functional. In two other patients, adequate function of transplanted adrenal tissue under basal conditions seemed likely. Hardy and Langford2 reported four patients with Cushing's disease in whom adrenal autotransplantation to the thigh was carried out. Viability of adrenocortical tissue was proved in two of the patients, but adrenocortical function was insufficient to allow withdrawal of replacement therapy. Ibbertson and O'Brien3 reported two patients in whom adrenal autotransplantation was attempted. In one it was possible to withdraw cortisone therapy References 1. Franksson, C.; Birke, G.; and Plantin, L.O.: Adrenal Autotransplantation in Cushing's Syndrome , Acta Chir Scand 117:409-415, 1959. 2. Hardy, J.D., and Langford, H.G.: Surgical Management of Cushing's Syndrome: Including Studies of Adrenal Autotransplants, Body Composition and Pseudotumor Cerebri , Ann Surg 159: 711-729, 1964.Crossref 3. Ibbertson, H.K., and O'Brien, K.P.: Adrenal Autografts in Treatment of Cushing's Disease , Brit Med J 2:703-706, 1962.Crossref 4. Norymberski, J.K.; Stubbs, R.D.; and West, H.F.: Assessment of Adrenocortical Activity by Assay of 17-ketogenic Steroids in Urine , Lancet 1: 1276-1281, 1953.Crossref 5. Sobel, C., et al: Study of the Norymberski Methods for Determination of 17-ketogenic Steroids (17-hydroxycorticosteroids) in Urine , J Clin Endocr 18:208-221, 1958.Crossref 6. Christy, N.P., et al: Inhibitory Effect of Chlorpromazine Upon the Adrenal Cortical Response to Insulin Hypoglycemia in Man , J Clin Invest 36:543-549, 1957.Crossref 7. Peterson, R.E.; Karrer, A.; and Guerra, S.L.: Evaluation of the Silber-Porter Procedure for Determination of Plasma Hydrocortisone , Anal Chem 29:144-149, 1957.Crossref 8. Chisty, N.P.: Wallace, E.Z.; and Jailer, J.W.: The Effect of Intravenously Administered ACTH on Plasma 17,21-dihydroxy-20-ketosteroids in Normal Individuals and in Patients With Disorders of the Adrenal Cortex , J Clin Invest 34:899-906, 1955.Crossref 9. Drucker, W.D.; Roginsky, M.S.; and Christy, N.P.: Persistence of Abnormal Pituitary-Adrenal Relationship in Patients With Cushing's Disease Partially Corrected by Bilateral Subtotal Adrenalectomy , Amer J Med 38:522-530, 1965.Crossref 10. Kliman, B., and Peterson, R.E.: Double Isotope Derivative Assay of Aldosterone in Biological Extracts , J Biol Chem 235:1639-1648, 1960. 11. Frantz, A.G., and Rabkin, M.T.: Human Growth Hormone: Clinical Measurement, Response to Hypoglycemia and Suppression by Corticosteroids , New Eng J Med 271:1375-1381, 1964.Crossref 12. VandeWiele, R.L., et al: " Studies on the Secretion and Interconversion of the Androgens ," in Pincus, G. (ed.): Recent Progress in Hormone Research , New York: Academic Press, vol 19, 1963, pp 275-310. 13. Drucker, W.D.; Blumberg, J.M.; and David, R.R.: Dehydroepiandrosterone Sulfate: Biologic Activity in Man, abstracted , Clin Res 14:279, 1966. 14. Symington, T.: " The Morphology and Zoning of the Human Adrenal Cortex , in Currie, A.P.; Symington, T.; and Grant, J.K. (eds.): Human Adrenal Cortex , Baltimore: William & Wilkins Co., 1962, pp 3-20. 15. O'Donnell, W.M.; Fajans, S.S.; and Weinbaum, J.: Human Adrenal Cortex After Administration of ACTH and Cortisone , Arch Intern Med 88:28-35, 1957.Crossref 16. Liddle, G.W.; Island, D.; and Meador, C.K.: " Normal and Abnormal Regulation of Corticotropin Secretion in Man ," in Pincus, G. (ed.): Recent Progress in Hormone Research , New York: Academic Press, vol 18, 1962, pp 125-166.
Archives of Internal Medicine – American Medical Association
Published: Aug 1, 1967