CLINICAL SCIENCES Autologous Fibrin Membrane Combined With Solid Platelet-Rich Plasma in the Management of Perforated Corneal Ulcers A Pilot Study Jorge L. Alio, PhD; Alejandra E. Rodriguez, MSc; Lorena M. Martinez, MD; Alvaro Luque Rio, MSc Importance: The combined use of autologous fibrin Main Outcomes and Measures: Corneal biomicros- membrane and the eye platelet-rich plasma (E-PRP) clot copy, fluorescein test, digital tonometry. could be considered as a new surgical alternative for the closure of corneal perforations. Results: In all cases the corneal perforation was sealed. The fibrin membrane was present over the corneal sur- Objective: To evaluate the use of autologous solid plate- face for the first 3 to 5 days and then gradually disap- let-rich plasma in combination with an autologous fi- peared. No evidence of infection or inflammation was de- brin membrane as a surgical alternative for wound clo- tected. Digital tonometry confirmed acceptable levels of sure in perforated corneal ulcers. ocular tonus in all cases from day 2 after the operation. No patients reported pain, discomfort, or other symp- Design: Both the fibrin membrane and the E-PRP clot toms, and no complications were observed. After 3 were prepared with the patient’s own blood just before months’
JAMA Ophthalmology – American Medical Association
Published: Jun 1, 2013
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