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Autologous 125I-Fibrinogen Uptake Test in the Detection and Management of Venous Thrombosis: A Prospective Study

Autologous 125I-Fibrinogen Uptake Test in the Detection and Management of Venous Thrombosis: A... Abstract The 125 I-fibrinogen uptake test (FUT) was evaluated in a series of 42 subjects to determine its ability to detect active venous thrombosis. Included were patients with recent active thrombosis, patients with long-standing quiescent venous obstruction, and normal controls. In serial tests, increasing isotope uptake was found to occur only in patients with active thrombophlebitis (P<.01). Consequently, this criterion can serve as an index of active thrombophlebitis. Five patients with known calf vein thrombosis had increasing FUT results at the upper thigh. Phlebography or technetium scans confirmed propagation of the thrombosis. These results suggest a screening value for the FUT in suspected propagating thrombosis. If results are confirmed by subsequent phlebography, major therapeutic changes such as intensification of anticoagulation or venous interruptions can hopefully be made before potentially lethal pulmonary embolism occurs. References 1. Kakkar V: The diagnosis of deep vein thrombosis using the 125I fibrinogen test . Arch Surg 104:152-159, 1972.Crossref 2. Webber MM, Victery W, Cragin MD: Demonstration of thrombophlebitis and endothelial damage by scintiscanning . Radiology 100:93-97, 1971.Crossref 3. Roberts RC, Sonnentag CO, Frisbie JH: Rapid preparation of autologous radioiodinated fibrinogen . J Nucl Med 13:843-846, 1973. 4. Bale WF, et al: High specific activity labeling of protein with I131 by the iodine monochloride method . Proc Soc Exp Biol Med 122:407-414, 1966.Crossref 5. Kirkegaard C, Djurhuris J, Eliasen B: 125I fibrinogen employed in the diagnosis of deep thrombophlebitis in the lower limbs . Ugeskr Laeger 134:1483-1484, 1972. 6. Jeyasingh K, et al: Criteria in radioisotope detection of venous thrombosis . Br Med J 3:500-503, 1972.Crossref 7. Hobbs JT, Davies JWL: Detection of venous thrombosis with 131I-labeled fibrinogen in the rabbit . Lancet 2:134-135, 1960.Crossref 8. Grady GF, et al: Risk of posttransfusional hepatitis in the United States: A prospective cooperative study . JAMA 220:692-701, 1972.Crossref 9. Becker J: The diagnosis of venous thrombosis in the legs using I-labelled fibrinogen: An experimental and clinical study . Acta Chir Scand 138:667-681, 1972. 10. Nanson EM, et al: Early detection of deep venous thrombosis of the legs using I131 tagged human fibrinogen . Ann Surg 162:438-445, 1965.Crossref 11. Dugan MA, Kozar JJ, Charkes ND: The use of iodinated fibrinogen for localization of deep venous thrombi by scintiscanning . Radiology 106:445-446, 1973.Crossref 12. Kiviniitty K, et al: Examination of postoperative thrombosis by means of fibrinogen-I-125 . Fortschr Geb Roentgenstr Nuklearmed 115:803-808, 1971.Crossref 13. Halpin DS, et al: Peripheral venous scanning with 125I-tagged fibrinogen . Lancet 1:845-846, 1972.Crossref 14. Browse NL: The 125I fibrinogen uptake test . Arch Surg 104:160-163, 1972.Crossref 15. Negus DD, et al: 125I-labeled fibrinogen in the diagnosis of deep-vein thrombosis and its correlation with phlebography . Br J Surg 55:835-839, 1968.Crossref 16. Kakkar VV: The management of deep vein thrombosis . Am Heart J 82:422-424, 1971.Crossref 17. Hartsuck JM, Greenfield LJ: Postoperative thromboembolism . Arch Surg 107:733-739, 1973.Crossref 18. Talbot S: Radioisotope detection of venous thrombosis . Br Med J 4:50, 1972.Crossref 19. Negus D: The diagnosis of deep vein thrombosis . Br J Surg 59:830-834, 1972.Crossref 20. Pollak EW, in discussion, Hartsuck JM, Greenfield LJ: Postoperative thromboembolism . Arch Surg 107:733-739, 1973.Crossref 21. Browse NL, et al: Diagnosis of established deep vein thrombosis with the 125I fibrinogen uptake test . Br Med J 4:325-328, 1971.Crossref 22. Mavor GE, Galloway JM: The iliofemoral venous segment as a source of pulmonary emboli . Lancet 1:871-874, 1967.Crossref 23. Nicolaides AN, et al: The origin of deep vein thrombosis: A venographic study . Br J Radiol 44:653-663, 1971.Crossref 24. Bauer G: Venographic study of thromboembolic problems . Acta Chir Scand 84:1-75, 1940. 25. Kakkar VV, Howe CT, Flanc C: Natural history of postoperative deep vein thrombosis . Lancet 2:230-232, 1969.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Autologous 125I-Fibrinogen Uptake Test in the Detection and Management of Venous Thrombosis: A Prospective Study

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Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1974.01360010034007
Publisher site
See Article on Publisher Site

Abstract

Abstract The 125 I-fibrinogen uptake test (FUT) was evaluated in a series of 42 subjects to determine its ability to detect active venous thrombosis. Included were patients with recent active thrombosis, patients with long-standing quiescent venous obstruction, and normal controls. In serial tests, increasing isotope uptake was found to occur only in patients with active thrombophlebitis (P<.01). Consequently, this criterion can serve as an index of active thrombophlebitis. Five patients with known calf vein thrombosis had increasing FUT results at the upper thigh. Phlebography or technetium scans confirmed propagation of the thrombosis. These results suggest a screening value for the FUT in suspected propagating thrombosis. If results are confirmed by subsequent phlebography, major therapeutic changes such as intensification of anticoagulation or venous interruptions can hopefully be made before potentially lethal pulmonary embolism occurs. References 1. Kakkar V: The diagnosis of deep vein thrombosis using the 125I fibrinogen test . Arch Surg 104:152-159, 1972.Crossref 2. Webber MM, Victery W, Cragin MD: Demonstration of thrombophlebitis and endothelial damage by scintiscanning . Radiology 100:93-97, 1971.Crossref 3. Roberts RC, Sonnentag CO, Frisbie JH: Rapid preparation of autologous radioiodinated fibrinogen . J Nucl Med 13:843-846, 1973. 4. Bale WF, et al: High specific activity labeling of protein with I131 by the iodine monochloride method . Proc Soc Exp Biol Med 122:407-414, 1966.Crossref 5. Kirkegaard C, Djurhuris J, Eliasen B: 125I fibrinogen employed in the diagnosis of deep thrombophlebitis in the lower limbs . Ugeskr Laeger 134:1483-1484, 1972. 6. Jeyasingh K, et al: Criteria in radioisotope detection of venous thrombosis . Br Med J 3:500-503, 1972.Crossref 7. Hobbs JT, Davies JWL: Detection of venous thrombosis with 131I-labeled fibrinogen in the rabbit . Lancet 2:134-135, 1960.Crossref 8. Grady GF, et al: Risk of posttransfusional hepatitis in the United States: A prospective cooperative study . JAMA 220:692-701, 1972.Crossref 9. Becker J: The diagnosis of venous thrombosis in the legs using I-labelled fibrinogen: An experimental and clinical study . Acta Chir Scand 138:667-681, 1972. 10. Nanson EM, et al: Early detection of deep venous thrombosis of the legs using I131 tagged human fibrinogen . Ann Surg 162:438-445, 1965.Crossref 11. Dugan MA, Kozar JJ, Charkes ND: The use of iodinated fibrinogen for localization of deep venous thrombi by scintiscanning . Radiology 106:445-446, 1973.Crossref 12. Kiviniitty K, et al: Examination of postoperative thrombosis by means of fibrinogen-I-125 . Fortschr Geb Roentgenstr Nuklearmed 115:803-808, 1971.Crossref 13. Halpin DS, et al: Peripheral venous scanning with 125I-tagged fibrinogen . Lancet 1:845-846, 1972.Crossref 14. Browse NL: The 125I fibrinogen uptake test . Arch Surg 104:160-163, 1972.Crossref 15. Negus DD, et al: 125I-labeled fibrinogen in the diagnosis of deep-vein thrombosis and its correlation with phlebography . Br J Surg 55:835-839, 1968.Crossref 16. Kakkar VV: The management of deep vein thrombosis . Am Heart J 82:422-424, 1971.Crossref 17. Hartsuck JM, Greenfield LJ: Postoperative thromboembolism . Arch Surg 107:733-739, 1973.Crossref 18. Talbot S: Radioisotope detection of venous thrombosis . Br Med J 4:50, 1972.Crossref 19. Negus D: The diagnosis of deep vein thrombosis . Br J Surg 59:830-834, 1972.Crossref 20. Pollak EW, in discussion, Hartsuck JM, Greenfield LJ: Postoperative thromboembolism . Arch Surg 107:733-739, 1973.Crossref 21. Browse NL, et al: Diagnosis of established deep vein thrombosis with the 125I fibrinogen uptake test . Br Med J 4:325-328, 1971.Crossref 22. Mavor GE, Galloway JM: The iliofemoral venous segment as a source of pulmonary emboli . Lancet 1:871-874, 1967.Crossref 23. Nicolaides AN, et al: The origin of deep vein thrombosis: A venographic study . Br J Radiol 44:653-663, 1971.Crossref 24. Bauer G: Venographic study of thromboembolic problems . Acta Chir Scand 84:1-75, 1940. 25. Kakkar VV, Howe CT, Flanc C: Natural history of postoperative deep vein thrombosis . Lancet 2:230-232, 1969.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Jul 1, 1974

References