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Autoimmune Complement Fixation Test in Endogenous Uveitis

Autoimmune Complement Fixation Test in Endogenous Uveitis Abstract Nowhere in ophthalmology can the diagnostic enthusiast give freer vent to his proclivities than in the pursuit of some infective cause for endogenous uveitis. Unfortunately his work most often terminates in only a presumptive or suggestive etiology. This has led Ashton1 to suspect that we are probably wrong in regarding uveitis as an infective disease and that we should explore other endogenous disturbances, either indirectly related or totally unrelated to infection. Gordon2 supports an allergic etiology by contending that antibiotics often fail to control uveitis, while adequate steroid hormone therapy usually produces a favorable response. The collagen diseases, which include rheumatoid arthritis and systemic lupus erythematosus, have gone through a similar period of disenchantment with infective causes and are now classified as autoimmune diseases, in which the patient becomes sensitized to certain of his own tissues. It is common knowledge that the incidence of uveitis in rheumatoid arthritis References 1. Ashton, N.: Allergic Factors in the Aetiology of Uveitis , in Acta 17th International Congress of Ophthalmology , Vol. 2, 1954, p. 1214. 2. Gordon, D. M.: Modern Therapy of Uveitis , Amer. J. Ophthal. 50:236, 1960. 3. Hallett, J. W.; Wolkowicz, M. I.; Leopold, I. H., and Wijewski, E.: Latex Agglutination Test in Uveitis , Arch. Ophthal. 64:133, 1960.Crossref 4. Svartz, N.: The Rheumatoid Factor and Its Significance , J.A.M.A. 177:50, 1961.Crossref 5. Ziff, M.: Editorial, Genetics: Hypersensitivity and the Connective Tissue Diseases , Amer. J. Med. 30:1, 1961.Crossref 6. Holman, H., and Robbins, W.: Antinuclear Antibodies in Systemic Lupus Erythematosus , Arthritis Rheum. 2:468, 1959.Crossref 7. Gajdusek, D. C.: An "Autoimmune" Reaction Against Human Tissue Antigens in Certain Acute and Chronic Diseases , A.M.A. Arch. Int. Med. 101: 9, 1958.Crossref 8. Woods, A. C: Ocular Anaphylaxis: III. The Role of Uveal Pigment , Arch. Ophthal. 46:283, 1917. 9. McPherson, S. D., Jr., and Woods, A. C.: The Significance of the Intracutaneous Test for Hypersensitivity to Uveal Pigment , Amer. J. Ophthal. 31:35, 1948. 10. Bloch, K. J.; Bunim, J. J.; Wohl, M. J., and Zvaifler, N. J.: Unusual Occurrence of Multiple Tissue Component Antibodies in Sjögren's Syndrome , Trans. Ass. Amer. Physicians 73:166, 1960. 11. Bardawil, W.; Toy, B.; Galins, N., and Bayles, T.: Disseminated Lupus Erythematosus, Scleroderma and Dermatomyositis as a Manifestations of Sensitization to DNA Protein: 1. An Immunohistochemical Approach , Amer. J. Path. 34:607, 1958. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Autoimmune Complement Fixation Test in Endogenous Uveitis

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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1962.00960030172005
Publisher site
See Article on Publisher Site

Abstract

Abstract Nowhere in ophthalmology can the diagnostic enthusiast give freer vent to his proclivities than in the pursuit of some infective cause for endogenous uveitis. Unfortunately his work most often terminates in only a presumptive or suggestive etiology. This has led Ashton1 to suspect that we are probably wrong in regarding uveitis as an infective disease and that we should explore other endogenous disturbances, either indirectly related or totally unrelated to infection. Gordon2 supports an allergic etiology by contending that antibiotics often fail to control uveitis, while adequate steroid hormone therapy usually produces a favorable response. The collagen diseases, which include rheumatoid arthritis and systemic lupus erythematosus, have gone through a similar period of disenchantment with infective causes and are now classified as autoimmune diseases, in which the patient becomes sensitized to certain of his own tissues. It is common knowledge that the incidence of uveitis in rheumatoid arthritis References 1. Ashton, N.: Allergic Factors in the Aetiology of Uveitis , in Acta 17th International Congress of Ophthalmology , Vol. 2, 1954, p. 1214. 2. Gordon, D. M.: Modern Therapy of Uveitis , Amer. J. Ophthal. 50:236, 1960. 3. Hallett, J. W.; Wolkowicz, M. I.; Leopold, I. H., and Wijewski, E.: Latex Agglutination Test in Uveitis , Arch. Ophthal. 64:133, 1960.Crossref 4. Svartz, N.: The Rheumatoid Factor and Its Significance , J.A.M.A. 177:50, 1961.Crossref 5. Ziff, M.: Editorial, Genetics: Hypersensitivity and the Connective Tissue Diseases , Amer. J. Med. 30:1, 1961.Crossref 6. Holman, H., and Robbins, W.: Antinuclear Antibodies in Systemic Lupus Erythematosus , Arthritis Rheum. 2:468, 1959.Crossref 7. Gajdusek, D. C.: An "Autoimmune" Reaction Against Human Tissue Antigens in Certain Acute and Chronic Diseases , A.M.A. Arch. Int. Med. 101: 9, 1958.Crossref 8. Woods, A. C: Ocular Anaphylaxis: III. The Role of Uveal Pigment , Arch. Ophthal. 46:283, 1917. 9. McPherson, S. D., Jr., and Woods, A. C.: The Significance of the Intracutaneous Test for Hypersensitivity to Uveal Pigment , Amer. J. Ophthal. 31:35, 1948. 10. Bloch, K. J.; Bunim, J. J.; Wohl, M. J., and Zvaifler, N. J.: Unusual Occurrence of Multiple Tissue Component Antibodies in Sjögren's Syndrome , Trans. Ass. Amer. Physicians 73:166, 1960. 11. Bardawil, W.; Toy, B.; Galins, N., and Bayles, T.: Disseminated Lupus Erythematosus, Scleroderma and Dermatomyositis as a Manifestations of Sensitization to DNA Protein: 1. An Immunohistochemical Approach , Amer. J. Path. 34:607, 1958.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Aug 1, 1962

References