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Autism Risk Across Generations

Autism Risk Across Generations ORIGINAL ARTICLE A Population-Based Study of Advancing Grandpaternal and Paternal Age Emma M. Frans, MSc; Sven Sandin, MSc; Abraham Reichenberg, PhD; Niklas La ˚ngstro ¨m, MD, PhD; Paul Lichtenstein, PhD; John J. McGrath, MD, PhD; Christina M. Hultman, PhD Importance: Advancing paternal age has been linked children. Men who had fathered a daughter when they to autism. were 50 years or older were 1.79 times (95% CI, 1.35- 2.37; P.001) more likely to have a grandchild with au- Objective: To further expand knowledge about the as- tism, and men who had fathered a son when they were sociation between paternal age and autism by studying 50 years or older were 1.67 times (95% CI, 1.35-2.37; the effect of grandfathers’ age on childhood autism. P.001) more likely to have a grandchild with autism, compared with men who had fathered children when they Design: Population-based, multigenerational, case- were 20 to 24 years old, after controlling for birth year control study. and sex of the child, age of the spouse, family history of psychiatric disorders, highest family educational level, Setting: Nationwide multigeneration and patient reg- and residential county. A statistically significant mono- isters in Sweden. tonic association was also found between advancing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/jamapsychiatry.2013.1180
pmid
23553111
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE A Population-Based Study of Advancing Grandpaternal and Paternal Age Emma M. Frans, MSc; Sven Sandin, MSc; Abraham Reichenberg, PhD; Niklas La ˚ngstro ¨m, MD, PhD; Paul Lichtenstein, PhD; John J. McGrath, MD, PhD; Christina M. Hultman, PhD Importance: Advancing paternal age has been linked children. Men who had fathered a daughter when they to autism. were 50 years or older were 1.79 times (95% CI, 1.35- 2.37; P.001) more likely to have a grandchild with au- Objective: To further expand knowledge about the as- tism, and men who had fathered a son when they were sociation between paternal age and autism by studying 50 years or older were 1.67 times (95% CI, 1.35-2.37; the effect of grandfathers’ age on childhood autism. P.001) more likely to have a grandchild with autism, compared with men who had fathered children when they Design: Population-based, multigenerational, case- were 20 to 24 years old, after controlling for birth year control study. and sex of the child, age of the spouse, family history of psychiatric disorders, highest family educational level, Setting: Nationwide multigeneration and patient reg- and residential county. A statistically significant mono- isters in Sweden. tonic association was also found between advancing

Journal

JAMA PsychiatryAmerican Medical Association

Published: May 1, 2013

References