Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Australia Antigen in Africans: An Anatomic, Clinical, and Immunologic Study

Australia Antigen in Africans: An Anatomic, Clinical, and Immunologic Study Abstract Chronic liver diseases in intertropical Africa are frequent and often cryptogenetic. With respect to the prevalence of Australia antigen (Au Ag) in different geographic regions we have studied in this preliminary work Au Ag frequency among various African populations, liver function and histological features; and antibodies of possible value in hepatology. Material and Patients Serum samples were obtained from two groups of subjects: (1) donors from various geographic origins: Abidjan (police school), Dakar (blood bank), and Timbuktu (military camp); and (2) patients from Abidjan (Treichville hospital) for whom we have no clinical information and from Paris (Claude Bernard Hospital). This later group is composed of male migrant workers from the same area of Mali; 96% are Sarakolle. The subjects were 20 to 35 years of age and were in the hospital for extra-hepatic manifestations (parasitosis or tuberculosis or both). Only one patient had had hepatitis in infancy, and three had References 1. Prince AM: An antigen detected in the blood during the incubation period of serum hepatitis . Proc Nat Acad Sci 60:814-821, 1968.Crossref 2. Pesendorfer F, Krassnitsky O, Wewalka FG: Immunoelectrophoretic methods . Bull WHO 42:974-975, 1970. 3. Eyquem P, de Saint Martin G: L'immunofluorescence et la détection des auto-anticorps anti-organes . Feuillets de Biologie 11:55-82, 1970. 4. Blumberg BS, Sutnick AI, London WT: Australia antigen as an hepatitis virus: Variation in host response . Amer J Med 48:1-8, 1970.Crossref 5. Prince AM: Prevalence of serum hepatitis antigen (SH) in different geographic regions . Amer J Trop Med 19:872-879, 1970. 6. Purcell RH, Walsh JH, Holland PV, et al: Sero-epidemiological studies of transfusion-associated hepatitis . J Infect Dis 123:406-413, 1971.Crossref 7. Shulman NR, Barker LF: Virus-like antigen, antibody, and antigen-antibody complexes in hepatitis measured by complement-fixation . Science 165:304-306, 1969.Crossref 8. Prince AM, Leblanc L, Khrohn K, Alpert ME: Sh antigen and chronic liver disease . Lancet 2:712-718, 1970. 9. Sutnick AI, London WT, Blumberg BS: Australia antigen: A genetic basis for chronic liver disease and hepatoma . Ann Intern Med 743:442-444, 1971.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Australia Antigen in Africans: An Anatomic, Clinical, and Immunologic Study

Download PDF
2 pages

Loading next page...
 
/lp/american-medical-association/australia-antigen-in-africans-an-anatomic-clinical-and-immunologic-khiDoZw5vO

References (9)

Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1972.02110100142054
Publisher site
See Article on Publisher Site

Abstract

Abstract Chronic liver diseases in intertropical Africa are frequent and often cryptogenetic. With respect to the prevalence of Australia antigen (Au Ag) in different geographic regions we have studied in this preliminary work Au Ag frequency among various African populations, liver function and histological features; and antibodies of possible value in hepatology. Material and Patients Serum samples were obtained from two groups of subjects: (1) donors from various geographic origins: Abidjan (police school), Dakar (blood bank), and Timbuktu (military camp); and (2) patients from Abidjan (Treichville hospital) for whom we have no clinical information and from Paris (Claude Bernard Hospital). This later group is composed of male migrant workers from the same area of Mali; 96% are Sarakolle. The subjects were 20 to 35 years of age and were in the hospital for extra-hepatic manifestations (parasitosis or tuberculosis or both). Only one patient had had hepatitis in infancy, and three had References 1. Prince AM: An antigen detected in the blood during the incubation period of serum hepatitis . Proc Nat Acad Sci 60:814-821, 1968.Crossref 2. Pesendorfer F, Krassnitsky O, Wewalka FG: Immunoelectrophoretic methods . Bull WHO 42:974-975, 1970. 3. Eyquem P, de Saint Martin G: L'immunofluorescence et la détection des auto-anticorps anti-organes . Feuillets de Biologie 11:55-82, 1970. 4. Blumberg BS, Sutnick AI, London WT: Australia antigen as an hepatitis virus: Variation in host response . Amer J Med 48:1-8, 1970.Crossref 5. Prince AM: Prevalence of serum hepatitis antigen (SH) in different geographic regions . Amer J Trop Med 19:872-879, 1970. 6. Purcell RH, Walsh JH, Holland PV, et al: Sero-epidemiological studies of transfusion-associated hepatitis . J Infect Dis 123:406-413, 1971.Crossref 7. Shulman NR, Barker LF: Virus-like antigen, antibody, and antigen-antibody complexes in hepatitis measured by complement-fixation . Science 165:304-306, 1969.Crossref 8. Prince AM, Leblanc L, Khrohn K, Alpert ME: Sh antigen and chronic liver disease . Lancet 2:712-718, 1970. 9. Sutnick AI, London WT, Blumberg BS: Australia antigen: A genetic basis for chronic liver disease and hepatoma . Ann Intern Med 743:442-444, 1971.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Apr 1, 1972

There are no references for this article.