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Augmented Betamethasone: Efficacy in Psoriasis With Different Dosing Frequencies

Augmented Betamethasone: Efficacy in Psoriasis With Different Dosing Frequencies Abstract Like most of the topical corticosteroids, augmented (optimized 0.05%) betamethasone dipropionate (ABD) is recommended to be used twice daily,1 despite a lack of evidence to establish this as the optimum schedule.2 Because of the depot effect of topical corticosteroids,3 it may be possible to reduce their dosing frequency without affecting the efficacy. We have recently concluded that there is no difference in the efficacy of ABD in the treatment of plaque psoriasis with twice daily vs once daily application.4 In the present study, the efficacy of ABD was evaluated with even lower dosing frequencies, ie, alternate day, once in 72 hours, and weekly. Patients and Methods. Patients with plaque psoriasis of more than 1 month and with at least 4 stable equivalent lesions (indicator lesions, 2 on each ventral forearm) were enrolled. Exclusion criteria included drug-induced psoriasis, psoriasis requiring systemic therapy, any treatment in the previous References 1. Tan PL, Barnett GL, Flowers FP, Araujo OE. Current topical corticosteroid preparations . J Am Acad Dermatol. 1986;14:79-83.Crossref 2. Stoughton RB, Cornell RC. Corticosteroids . In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF, eds. Dermatology in General Medicine. 4th ed. New York, NY: McGraw-Hill Inc; 1993:2846-2850. 3. Vickers CFH. Existence of reservoir in the stratum corneum: experimental proof . Arch Dermatol. 1963;88:72-75.Crossref 4. Singh S, Gopal J, Mishra RN, Pandey SS. Topical 0.05% betamethasone dipropionate: efficacy in psoriasis with once a day vs twice a day application . Br J Dermatol. 1995;133:497-498.Crossref 5. Rogers RS. Frequency of application of topical corticosteroids . Int J Dermatol. 1981;20:616.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Augmented Betamethasone: Efficacy in Psoriasis With Different Dosing Frequencies

Archives of Dermatology , Volume 132 (12) – Dec 1, 1996

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Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1996.03890360119032
Publisher site
See Article on Publisher Site

Abstract

Abstract Like most of the topical corticosteroids, augmented (optimized 0.05%) betamethasone dipropionate (ABD) is recommended to be used twice daily,1 despite a lack of evidence to establish this as the optimum schedule.2 Because of the depot effect of topical corticosteroids,3 it may be possible to reduce their dosing frequency without affecting the efficacy. We have recently concluded that there is no difference in the efficacy of ABD in the treatment of plaque psoriasis with twice daily vs once daily application.4 In the present study, the efficacy of ABD was evaluated with even lower dosing frequencies, ie, alternate day, once in 72 hours, and weekly. Patients and Methods. Patients with plaque psoriasis of more than 1 month and with at least 4 stable equivalent lesions (indicator lesions, 2 on each ventral forearm) were enrolled. Exclusion criteria included drug-induced psoriasis, psoriasis requiring systemic therapy, any treatment in the previous References 1. Tan PL, Barnett GL, Flowers FP, Araujo OE. Current topical corticosteroid preparations . J Am Acad Dermatol. 1986;14:79-83.Crossref 2. Stoughton RB, Cornell RC. Corticosteroids . In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF, eds. Dermatology in General Medicine. 4th ed. New York, NY: McGraw-Hill Inc; 1993:2846-2850. 3. Vickers CFH. Existence of reservoir in the stratum corneum: experimental proof . Arch Dermatol. 1963;88:72-75.Crossref 4. Singh S, Gopal J, Mishra RN, Pandey SS. Topical 0.05% betamethasone dipropionate: efficacy in psoriasis with once a day vs twice a day application . Br J Dermatol. 1995;133:497-498.Crossref 5. Rogers RS. Frequency of application of topical corticosteroids . Int J Dermatol. 1981;20:616.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1996

References