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Cornell RC Stoughton RB (1993)
Dermatology in General Medicine.
S. Singh, J. Gopal, R. Mishra, S. Pandey (1995)
Topical 0.05% betamethasone dipropionate: efficacy in psoriasis with once a day vs. twice a day applicationBritish Journal of Dermatology, 133
R. Rogers (1981)
Frequency of Application of Topical CorticosteroidsInternational Journal of Dermatology, 20
P. Tan, G. Barnett, F. Flowers, O. Araujo (1986)
Current topical corticosteroid preparations.Journal of the American Academy of Dermatology, 14 1
C. Vickers (1963)
EXISTENCE OF RESERVOIR IN THE STRATUM CORNEUM. EXPERIMENTAL PROOF.Archives of dermatology, 88
Abstract Like most of the topical corticosteroids, augmented (optimized 0.05%) betamethasone dipropionate (ABD) is recommended to be used twice daily,1 despite a lack of evidence to establish this as the optimum schedule.2 Because of the depot effect of topical corticosteroids,3 it may be possible to reduce their dosing frequency without affecting the efficacy. We have recently concluded that there is no difference in the efficacy of ABD in the treatment of plaque psoriasis with twice daily vs once daily application.4 In the present study, the efficacy of ABD was evaluated with even lower dosing frequencies, ie, alternate day, once in 72 hours, and weekly. Patients and Methods. Patients with plaque psoriasis of more than 1 month and with at least 4 stable equivalent lesions (indicator lesions, 2 on each ventral forearm) were enrolled. Exclusion criteria included drug-induced psoriasis, psoriasis requiring systemic therapy, any treatment in the previous References 1. Tan PL, Barnett GL, Flowers FP, Araujo OE. Current topical corticosteroid preparations . J Am Acad Dermatol. 1986;14:79-83.Crossref 2. Stoughton RB, Cornell RC. Corticosteroids . In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF, eds. Dermatology in General Medicine. 4th ed. New York, NY: McGraw-Hill Inc; 1993:2846-2850. 3. Vickers CFH. Existence of reservoir in the stratum corneum: experimental proof . Arch Dermatol. 1963;88:72-75.Crossref 4. Singh S, Gopal J, Mishra RN, Pandey SS. Topical 0.05% betamethasone dipropionate: efficacy in psoriasis with once a day vs twice a day application . Br J Dermatol. 1995;133:497-498.Crossref 5. Rogers RS. Frequency of application of topical corticosteroids . Int J Dermatol. 1981;20:616.Crossref
Archives of Dermatology – American Medical Association
Published: Dec 1, 1996
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