Abstract • Auditory brainstem-evoked responses (ABR) to clicks were recorded in unanesthetized restrained cats before, during, and after systemic intravenous infusion of lidocaine hydrochloride. The drug was infused continuously at varying rates. Lidocaine's major effect on ABR was to lengthen latent periods to all waveform peaks in proportion with the infusion rate. The effect on latent periods was cumulative throughout the auditory brainstem, ie, all interpeak time intervals increased. Increases in ABR latencies were not due to reductions in effective stimulus intensity because lidocaine did not reduce ABR component amplitudes or increase thresholds. The effects of the drug were reversible. The data are consistent with the notion that lidocaine, directly or indirectly, works throughout the auditory brainstem to increase axonal and synaptic conduction times. (Arch Otolaryngol 1982;108:71-76) References 1. Arnsdorf MF, Bigger JT Jr: Effect of lidocaine hydrochloride on membrane conductance in mammalian cardiac Purkinje fibers . J Clin Invest 1972;51:2252-2263.Crossref 2. Bonica JJ (ed): Advances in Pain Research and Therapy . New York, Raven Press, 1976. 3. Bernhard CG, Bohm E: On the central effects of Xylocaine with special reference to its influence on epileptic phenomena . Acta Physiol Scand 1954;31( (suppl 114) ):5-6.Crossref 4. Strichartz GR: The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine . J Gen Physiol 1973;62:37-57.Crossref 5. Ritchie JM, Cohen PJ: Cocaine, procaine and other synthetic local anesthetics , in Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics , ed 5. New York, Macmillan Publishing Co Inc, 1975, p 379. 6. Lewy RB: Treatment of tinnitus aurium by the intravenous use of local anesthetic agents . Arch Otolaryngol 1937;25:178-183.Crossref 7. Englesson S, Larsson B, Lindquist NG, et al: Accumulation of 14C-lidocaine in the inner ear . Acta Otolaryngol 1976;82:297-300.Crossref 8. Gejrot T: Intravenous Xylocaine in the treatment of attacks of Meniere's disease . Acta Otolaryngol 1963;80( (suppl 188) ):190-195. 9. Melding PS, Goodey RJ, Thorne PR: The use of intravenous lignocaine in the diagnosis and treatment of tinnitus . J Laryngol Otol 1978;92:115-121.Crossref 10. Rahm WE, Strother WF, Crump JF, et al: The effects of anesthetics upon the ear: IV. Lidocaine hydrochloride . Ann Otol Rhinol Laryngol 1962;71:116-123. 11. Ward PH, Honrubia V: The effects of local anesthetics on the cochlea of the guinea pig . Laryngoscope 1969;79:1605-1617.Crossref 12. Shea JJ, Harell M: Management of tinnitus aurium with lidocaine and carbamazepine . Laryngoscope 1978;88:1477-1484. 13. Wilpizeski CR, Lowry LD: Effects of intravascular lidocaine, fluid bolus and broadband noise on brainstem evoked responses in guinea pigs . Abstr Assoc Res Otolaryngol , 1981, p 72. 14. Keenaghan JB, Boyes RN: The tissue distribution, metabolism and excretion of lidocaine in rats, guinea pigs, dogs and man . J Pharmacol Exp Ther 1972;180:454-463. 15. Austen WG, Moran JM: Cardiac and peripheral vascular effects of lidocaine and procainamide . Am J Cardiol 1965;16:701-707.Crossref 16. Sugimori M, Llinas R: Lidocaine differentially blocks fast and slowly inactivating sodium conductance in Purkinje cells . Neurosci Abstr 1980;6:468. 17. Achor LJ, Starr A: Auditory brain stem responses in the cat: I. Intracranial and extracranial recordings . Electroencephalogr Clin Neurophysiol 1980;48:154-173.Crossref 18. Jewett DL, Romano MN: Neonatal development of auditory system potentials averaged from the scalp of rat and cat . Brain Res 1972;36:101-115.Crossref 19. Bobbin RP, May JG, Lemoine RL: Effects of pentobarbital and ketamine on brainstem auditory potentials . Arch Otolaryngol 1979;105:467-470.Crossref 20. Kiang NYS, Neame JH, Clark LF: Evoked cortical activity from auditory cortex in anesthetized and unanesthetized cats . Science 1961;133:1927-1928.Crossref 21. Pradhan SN, Galambos R: Some effects of anesthetics on the evoked responses in the auditory cortex of cats . J Pharmacol Exp Ther 1963;139:97-106. 22. Elliott DN, Trahiotis C: Cortical lesions and auditory discriminations . Psychol Bull 1972;77:198-222.Crossref 23. Boyes RN, Scott DB, Jebson PJ, et al: Pharmacokinetics of lidocaine in man . Clin Pharmacol Ther 1971;12:105-116.
Archives of Otolaryngology – American Medical Association
Published: Feb 1, 1982
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