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Atypical Fibroxanthoma in a Patient With Xeroderma Pigmentosum

Atypical Fibroxanthoma in a Patient With Xeroderma Pigmentosum Abstract • A 3-year-old boy with xeroderma pigmentosum developed a papule on the right ala nasi that had the light-microscopic, immunohistochemical, and ultrastructural features of atypical fibroxanthoma. This lesion most commonly arises on the sun-exposed skin of older adults. The occurrence of an atypical fibroxanthoma in such a patient adds weight to the concept that this tumor of "fibrohistiocytic" origin is induced by ultraviolet exposure. Mechanisms of tumor formation in a patient with xeroderma pigmentosum may be similar to those occurring in the more typical situation in adults. (Arch Dermatol 1987;123:1066-1070) References 1. Fretzin DF, Helwig EB: Atypical fibroxanthoma of the skin: A clinicopathologic study of 140 cases . Cancer 1973;31:1541-1552.Crossref 2. Helwig EB, May DL: Atypical fibroxanthoma of the skin with metastasis . Cancer 1986;57:368-376.Crossref 3. Kuwano H, Hashimoto H, Enjoji M: Atypical fibroxanthoma distinguishable from spindle cell carcinoma in sarcoma-like skin lesions: A clinicopathologic and immunohistochemical study of 21 cases . Cancer 1985;55:172-180.Crossref 4. Barr RJ, Wuerker RB, Graham JH: Ultrastructure of atypical fibroxanthoma . Cancer 1977;40:736-743.Crossref 5. Lynch HT, Fusaro RM: Xeroderma pigmentosum , in Cancer-Associated Genodermatoses . New York, Van Nostrand Reinhold Co, 1982, pp 116-117, 465-494. 6. Robbins JH, Kraemer KH, Lutzner MA, et al: Xeroderma pigmentosum: An inherited disorder with sun sensitivity, multiple cutaneous neoplasms, and abnormal DNA repair . Ann Intern Med 1974;80:221-248.Crossref 7. Cleaver JE: Xeroderma pigmentosum: Genetic and environmental influences in skin carcinogenesis . Int J Dermatol 1978;17:435-444.Crossref 8. Hsu SM, Raine L, Fanger H: Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase technique: A comparison between ABC and unlabeled antibody (PAP) procedures . J Histochem Cytochem 1981;29:577-580.Crossref 9. Halpert B, Hackney VC: Fibrosarcoma of the helix of the ear . Arch Pathol Lab Med 1949;48:218-220. 10. Alguacil-Garcia A, Unni KK, Goellner JR, et al: Atypical fibroxanthoma of the skin: An ultrastructural study of two cases . Cancer 1977;40:1471-1480.Crossref 11. Weedon D, Kerr JRF: Atypical fibroxanthoma of skin: An electron microscope study . Pathology 1975;7:173-177.Crossref 12. Woyke S, Domagala W, Olszewski W, et al: Pseudosarcoma of the skin: An electron microscopic study and comparison with the fine structure of the spindle cell variant of squamous carcinoma . Cancer 1974;33:970-980.Crossref 13. Enzinger FM, Weiss SW: Malignant fibrohistiocytic tumors , in Soft-Tissue Tumors . St Louis, CV Mosby Co, 1983, pp 167-170. 14. Butterworth T, Ladda RL: Xeroderma pigmentosum , in Clinical Genodermatology . New York, Praeger Publishers, 1981, pp 3-8. 15. Patton JD, Rowan LA, Mendrala AL, et al: Xeroderma pigmentosum fibroblasts including cells from XP variants are abnormally sensitive to the mutagenic and cytotoxic action of broad-spectrum simulated sunlight . Photochem Photobiol 1984;39:37-42.Crossref 16. Kraemer KH, Lee MM, Scott J: DNA repair protects against cutaneous and internal neo1984;5:511-514.e from xeroderma pigmentosum . Carcinogenesis 1984;5:511-514.Crossref 17. Morison WL, Bucana C, Kripke ML, et al: Impaired immune function in patients with xeroderma pigmentosum . Cancer Res 1985;45:3929-3931. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Atypical Fibroxanthoma in a Patient With Xeroderma Pigmentosum

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1987.01660320108023
Publisher site
See Article on Publisher Site

Abstract

Abstract • A 3-year-old boy with xeroderma pigmentosum developed a papule on the right ala nasi that had the light-microscopic, immunohistochemical, and ultrastructural features of atypical fibroxanthoma. This lesion most commonly arises on the sun-exposed skin of older adults. The occurrence of an atypical fibroxanthoma in such a patient adds weight to the concept that this tumor of "fibrohistiocytic" origin is induced by ultraviolet exposure. Mechanisms of tumor formation in a patient with xeroderma pigmentosum may be similar to those occurring in the more typical situation in adults. (Arch Dermatol 1987;123:1066-1070) References 1. Fretzin DF, Helwig EB: Atypical fibroxanthoma of the skin: A clinicopathologic study of 140 cases . Cancer 1973;31:1541-1552.Crossref 2. Helwig EB, May DL: Atypical fibroxanthoma of the skin with metastasis . Cancer 1986;57:368-376.Crossref 3. Kuwano H, Hashimoto H, Enjoji M: Atypical fibroxanthoma distinguishable from spindle cell carcinoma in sarcoma-like skin lesions: A clinicopathologic and immunohistochemical study of 21 cases . Cancer 1985;55:172-180.Crossref 4. Barr RJ, Wuerker RB, Graham JH: Ultrastructure of atypical fibroxanthoma . Cancer 1977;40:736-743.Crossref 5. Lynch HT, Fusaro RM: Xeroderma pigmentosum , in Cancer-Associated Genodermatoses . New York, Van Nostrand Reinhold Co, 1982, pp 116-117, 465-494. 6. Robbins JH, Kraemer KH, Lutzner MA, et al: Xeroderma pigmentosum: An inherited disorder with sun sensitivity, multiple cutaneous neoplasms, and abnormal DNA repair . Ann Intern Med 1974;80:221-248.Crossref 7. Cleaver JE: Xeroderma pigmentosum: Genetic and environmental influences in skin carcinogenesis . Int J Dermatol 1978;17:435-444.Crossref 8. Hsu SM, Raine L, Fanger H: Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase technique: A comparison between ABC and unlabeled antibody (PAP) procedures . J Histochem Cytochem 1981;29:577-580.Crossref 9. Halpert B, Hackney VC: Fibrosarcoma of the helix of the ear . Arch Pathol Lab Med 1949;48:218-220. 10. Alguacil-Garcia A, Unni KK, Goellner JR, et al: Atypical fibroxanthoma of the skin: An ultrastructural study of two cases . Cancer 1977;40:1471-1480.Crossref 11. Weedon D, Kerr JRF: Atypical fibroxanthoma of skin: An electron microscope study . Pathology 1975;7:173-177.Crossref 12. Woyke S, Domagala W, Olszewski W, et al: Pseudosarcoma of the skin: An electron microscopic study and comparison with the fine structure of the spindle cell variant of squamous carcinoma . Cancer 1974;33:970-980.Crossref 13. Enzinger FM, Weiss SW: Malignant fibrohistiocytic tumors , in Soft-Tissue Tumors . St Louis, CV Mosby Co, 1983, pp 167-170. 14. Butterworth T, Ladda RL: Xeroderma pigmentosum , in Clinical Genodermatology . New York, Praeger Publishers, 1981, pp 3-8. 15. Patton JD, Rowan LA, Mendrala AL, et al: Xeroderma pigmentosum fibroblasts including cells from XP variants are abnormally sensitive to the mutagenic and cytotoxic action of broad-spectrum simulated sunlight . Photochem Photobiol 1984;39:37-42.Crossref 16. Kraemer KH, Lee MM, Scott J: DNA repair protects against cutaneous and internal neo1984;5:511-514.e from xeroderma pigmentosum . Carcinogenesis 1984;5:511-514.Crossref 17. Morison WL, Bucana C, Kripke ML, et al: Impaired immune function in patients with xeroderma pigmentosum . Cancer Res 1985;45:3929-3931.

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1987

References