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Attempted Regional Heparinization of the Heart

Attempted Regional Heparinization of the Heart Abstract CERTAIN cardiac procedures might be more uniformly successful and free of complications if it were possible to maintain for a period of time a prolonged coagulation time of the blood within the heart and, at the same time, a normal clotting mechanism in the systemic circuit. The successful utilization of regional heparinization in conjunction with hemodialysis1,2 in extracorporeal liver perfusion studies3 provided a new element of hope and prompted the present study. Experimental Procedure Healthy mongrel dogs, ranging in weight from 7.4 to 26.4 kg, were used. They were anesthetized by the intravenous administration of thiopental sodium (Pentothal). Following tracheal intubation, controlled respirations were maintained with a mechanical ventilator. Two groups of animals were studied.In the first group of 28 dogs, sodium heparin was administered through a No. 18 polyethylene catheter inserted into the left atrium through its appendage. Blood samples were drawn from 12-gauge Teflon catheters References 1. Gordon, L.A.; Richards, B.; and Perkins, H.A.: Studies in Regional Heparinization: Use of Simultaneous Neutralization With Protamine—Preliminary Studies , New Eng J Med 255:1025-1029 ( (Nov 29) ) 1956.Crossref 2. Gordon, L.A., et al: Studies in Regional Heparinization: Artificial Kidney Hemodialysis Without Systemic Heparinization—Preliminary Report of a Method Using Simultaneous Infusion of Heparin and Protamine , New Eng J Med 255:1063-1066 ( (Dec 6) ) 1956.Crossref 3. Eiseman, B.; Liem, D.S.; and Raffucci, F.: Heterologous Liver Perfusion in Treatment of Hepatic Failure , Ann Surg 162:329-345 ( (Sept) ) 1965.Crossref 4. Lee, R.I., and White, P.D.: A Clinical Study of the Coagulation Time of Blood , Amer J Med Sci 145:495-503, 1913.Crossref 5. Murray, G.D.W., and Best, C.H.: The Use of Heparin in Thrombosis , Ann Surg 108:163-177 ( (Aug) ) 1938.Crossref 6. Wylie, E.J., et al: An Experimental Study of Regional Heparinization , Surgery 28:29-36 ( (July) ) 1950. 7. Freeman, N.E.; Wylie, E.J.; and Gilfillan, R.S.: Regional Heparinization in Vascular Surgery , Surg Gynec Obstet 90:406-412 ( (April) ) 1950. 8. Ohlwiler, B.A., and Mahoney, E.B.: Regional Heparinization and Heparin Inactivation by Erythrocytes , Surg Gynec Obstet 107:353-358 ( (Sept) ) 1958. 9. Jacques, L.B.: The Effect of Intravenous Injections of Heparin in the Dog , Amer J Physiol 125:98-107 ( (Jan) ) 1939. 10. Hardaway, R.M., et al: Clotting Time of Heparinized Blood: Influence of Acidosis , Arch Surg 89: 701-705 ( (Oct) ) 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Attempted Regional Heparinization of the Heart

Archives of Surgery , Volume 93 (5) – Nov 1, 1966

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1966.01330050128018
Publisher site
See Article on Publisher Site

Abstract

Abstract CERTAIN cardiac procedures might be more uniformly successful and free of complications if it were possible to maintain for a period of time a prolonged coagulation time of the blood within the heart and, at the same time, a normal clotting mechanism in the systemic circuit. The successful utilization of regional heparinization in conjunction with hemodialysis1,2 in extracorporeal liver perfusion studies3 provided a new element of hope and prompted the present study. Experimental Procedure Healthy mongrel dogs, ranging in weight from 7.4 to 26.4 kg, were used. They were anesthetized by the intravenous administration of thiopental sodium (Pentothal). Following tracheal intubation, controlled respirations were maintained with a mechanical ventilator. Two groups of animals were studied.In the first group of 28 dogs, sodium heparin was administered through a No. 18 polyethylene catheter inserted into the left atrium through its appendage. Blood samples were drawn from 12-gauge Teflon catheters References 1. Gordon, L.A.; Richards, B.; and Perkins, H.A.: Studies in Regional Heparinization: Use of Simultaneous Neutralization With Protamine—Preliminary Studies , New Eng J Med 255:1025-1029 ( (Nov 29) ) 1956.Crossref 2. Gordon, L.A., et al: Studies in Regional Heparinization: Artificial Kidney Hemodialysis Without Systemic Heparinization—Preliminary Report of a Method Using Simultaneous Infusion of Heparin and Protamine , New Eng J Med 255:1063-1066 ( (Dec 6) ) 1956.Crossref 3. Eiseman, B.; Liem, D.S.; and Raffucci, F.: Heterologous Liver Perfusion in Treatment of Hepatic Failure , Ann Surg 162:329-345 ( (Sept) ) 1965.Crossref 4. Lee, R.I., and White, P.D.: A Clinical Study of the Coagulation Time of Blood , Amer J Med Sci 145:495-503, 1913.Crossref 5. Murray, G.D.W., and Best, C.H.: The Use of Heparin in Thrombosis , Ann Surg 108:163-177 ( (Aug) ) 1938.Crossref 6. Wylie, E.J., et al: An Experimental Study of Regional Heparinization , Surgery 28:29-36 ( (July) ) 1950. 7. Freeman, N.E.; Wylie, E.J.; and Gilfillan, R.S.: Regional Heparinization in Vascular Surgery , Surg Gynec Obstet 90:406-412 ( (April) ) 1950. 8. Ohlwiler, B.A., and Mahoney, E.B.: Regional Heparinization and Heparin Inactivation by Erythrocytes , Surg Gynec Obstet 107:353-358 ( (Sept) ) 1958. 9. Jacques, L.B.: The Effect of Intravenous Injections of Heparin in the Dog , Amer J Physiol 125:98-107 ( (Jan) ) 1939. 10. Hardaway, R.M., et al: Clotting Time of Heparinized Blood: Influence of Acidosis , Arch Surg 89: 701-705 ( (Oct) ) 1964.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Nov 1, 1966

References